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Protein

Protein AmpG

Gene

ampG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as a permease in the beta-lactamase induction system and in peptidoglycan recycling.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:AMPG-MONOMER.
ECOL316407:JW0423-MONOMER.
MetaCyc:AMPG-MONOMER.

Protein family/group databases

TCDBi2.A.1.25.2. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AmpG
Gene namesi
Name:ampG
Ordered Locus Names:b0433, JW0423
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12183. ampG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence analysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Topological domaini34 – 8047PeriplasmicSequence analysisAdd
BLAST
Transmembranei81 – 10525HelicalSequence analysisAdd
BLAST
Topological domaini106 – 1094CytoplasmicSequence analysis
Transmembranei110 – 12819HelicalSequence analysisAdd
BLAST
Topological domaini129 – 17345PeriplasmicSequence analysisAdd
BLAST
Transmembranei174 – 19724HelicalSequence analysisAdd
BLAST
Topological domaini198 – 22326CytoplasmicSequence analysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Topological domaini245 – 26521PeriplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28318HelicalSequence analysisAdd
BLAST
Topological domaini284 – 32744CytoplasmicSequence analysisAdd
BLAST
Transmembranei328 – 34518HelicalSequence analysisAdd
BLAST
Topological domaini346 – 38136PeriplasmicSequence analysisAdd
BLAST
Transmembranei382 – 40625HelicalSequence analysisAdd
BLAST
Topological domaini407 – 42418CytoplasmicSequence analysisAdd
BLAST
Transmembranei425 – 45026HelicalSequence analysisAdd
BLAST
Topological domaini451 – 46010PeriplasmicSequence analysis
Transmembranei461 – 48525HelicalSequence analysisAdd
BLAST
Topological domaini486 – 4916CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Protein AmpGPRO_0000084830Add
BLAST

Proteomic databases

PaxDbiP0AE16.

Interactioni

Protein-protein interaction databases

BioGridi4259838. 195 interactions.
STRINGi511145.b0433.

Structurei

3D structure databases

ProteinModelPortaliP0AE16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EYM. Bacteria.
COG0477. LUCA.
HOGENOMiHOG000217208.
InParanoidiP0AE16.
KOiK08218.
OMAiGYFSWIA.
OrthoDBiEOG6PS5R8.
PhylomeDBiP0AE16.

Family and domain databases

InterProiIPR004752. AmpG_permease/AT-1.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQYLRIFQ QPRSAILLIL GFASGLPLAL TSGTLQAWMT VENIDLKTIG
60 70 80 90 100
FFSLVGQAYV FKFLWSPLMD RYTPPFFGRR RGWLLATQIL LLVAIAAMGF
110 120 130 140 150
LEPGTQLRWM AALAVVIAFC SASQDIVFDA WKTDVLPAEE RGAGAAISVL
160 170 180 190 200
GYRLGMLVSG GLALWLADKW LGWQGMYWLM AALLIPCIIA TLLAPEPTDT
210 220 230 240 250
IPVPKTLEQA VVAPLRDFFG RNNAWLILLL IVLYKLGDAF AMSLTTTFLI
260 270 280 290 300
RGVGFDAGEV GVVNKTLGLL ATIVGALYGG ILMQRLSLFR ALLIFGILQG
310 320 330 340 350
ASNAGYWLLS ITDKHLYSMG AAVFFENLCG GMGTSAFVAL LMTLCNKSFS
360 370 380 390 400
ATQFALLSAL SAVGRVYVGP VAGWFVEAHG WSTFYLFSVA AAVPGLILLL
410 420 430 440 450
VCRQTLEYTR VNDNFISRTA YPAGYAFAMW TLAAGVSLLA VWLLLLTMDA
460 470 480 490
LDLTHFSFLP ALLEVGVLVA LSGVVLGGLL DYLALRKTHL T
Length:491
Mass (Da):53,245
Last modified:December 6, 2005 - v1
Checksum:i6B0D7E2BC699CA9C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511G → D in non-inducible mutant SN0301-1.
Natural varianti268 – 2681G → D in non-inducible mutant SN0301-3.
Natural varianti373 – 3731G → D in non-inducible mutant SN0301-5.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67816 Genomic DNA. Translation: AAB28884.1.
X82158 mRNA. Translation: CAA57651.1.
X82159 mRNA. Translation: CAA57652.1.
X82160 mRNA. Translation: CAA57653.1.
U82664 Genomic DNA. Translation: AAB40189.1.
U00096 Genomic DNA. Translation: AAC73536.1.
AP009048 Genomic DNA. Translation: BAE76213.1.
PIRiS37391.
RefSeqiNP_414967.1. NC_000913.3.
WP_000098429.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73536; AAC73536; b0433.
BAE76213; BAE76213; BAE76213.
GeneIDi946438.
KEGGiecj:JW0423.
eco:b0433.
PATRICi32116017. VBIEscCol129921_0450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67816 Genomic DNA. Translation: AAB28884.1.
X82158 mRNA. Translation: CAA57651.1.
X82159 mRNA. Translation: CAA57652.1.
X82160 mRNA. Translation: CAA57653.1.
U82664 Genomic DNA. Translation: AAB40189.1.
U00096 Genomic DNA. Translation: AAC73536.1.
AP009048 Genomic DNA. Translation: BAE76213.1.
PIRiS37391.
RefSeqiNP_414967.1. NC_000913.3.
WP_000098429.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AE16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259838. 195 interactions.
STRINGi511145.b0433.

Protein family/group databases

TCDBi2.A.1.25.2. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP0AE16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73536; AAC73536; b0433.
BAE76213; BAE76213; BAE76213.
GeneIDi946438.
KEGGiecj:JW0423.
eco:b0433.
PATRICi32116017. VBIEscCol129921_0450.

Organism-specific databases

EchoBASEiEB2100.
EcoGeneiEG12183. ampG.

Phylogenomic databases

eggNOGiENOG4105EYM. Bacteria.
COG0477. LUCA.
HOGENOMiHOG000217208.
InParanoidiP0AE16.
KOiK08218.
OMAiGYFSWIA.
OrthoDBiEOG6PS5R8.
PhylomeDBiP0AE16.

Enzyme and pathway databases

BioCyciEcoCyc:AMPG-MONOMER.
ECOL316407:JW0423-MONOMER.
MetaCyc:AMPG-MONOMER.

Miscellaneous databases

PROiP0AE16.

Family and domain databases

InterProiIPR004752. AmpG_permease/AT-1.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00901. 2A0125. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers."
    Schmidt H., Korfmann G., Barth H., Martin H.H.
    Microbiology 141:1085-1092(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SN0301-1, SN0301-3 and SN0301-5.
  3. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiAMPG_ECOLI
AccessioniPrimary (citable) accession number: P0AE16
Secondary accession number(s): P36670, Q2MBZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.