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Protein

Protein AmpE

Gene

ampE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams.

Enzyme and pathway databases

BioCyciEcoCyc:EG10042-MONOMER.
ECOL316407:JW0107-MONOMER.

Protein family/group databases

TCDBi9.B.125.1.1. the ampe/cobd (ampe/cobd) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AmpE
Gene namesi
Name:ampE
Ordered Locus Names:b0111, JW0107
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10042. ampE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343PeriplasmicSequence analysisAdd
BLAST
Transmembranei44 – 6017HelicalSequence analysisAdd
BLAST
Topological domaini61 – 677CytoplasmicSequence analysis
Transmembranei68 – 8417HelicalSequence analysisAdd
BLAST
Topological domaini85 – 194110PeriplasmicSequence analysisAdd
BLAST
Transmembranei195 – 21117HelicalSequence analysisAdd
BLAST
Topological domaini212 – 26756CytoplasmicSequence analysisAdd
BLAST
Transmembranei268 – 28417HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Protein AmpEPRO_0000064592Add
BLAST

Proteomic databases

PaxDbiP0AE14.

Expressioni

Inductioni

The level of AmpE affects the basal level of beta-lactamase expression in the absence of AmpD and in the presence of the AmpR transcriptional regulator.

Interactioni

Protein-protein interaction databases

BioGridi4259732. 5 interactions.
DIPiDIP-47964N.
IntActiP0AE14. 2 interactions.
STRINGi511145.b0111.

Structurei

3D structure databases

ProteinModelPortaliP0AE14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106A72. Bacteria.
COG3725. LUCA.
HOGENOMiHOG000116788.
KOiK03807.
OMAiHFSRALP.

Family and domain databases

InterProiIPR031347. AmpE.
[Graphical view]
PfamiPF17113. AmpE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLFTTLLVL IFERLFKLGE HWQLDHRLEA FFRRVKHFSL GRTLGMTIIA
60 70 80 90 100
MGVTFLLLRA LQGVLFNVPT LLVWLLIGLL CIGAGKVRLH YHAYLTAASR
110 120 130 140 150
NDSHARATMA GELTMIHGVP AGCDEREYLR ELQNALLWIN FRFYLAPLFW
160 170 180 190 200
LIVGGTWGPV TLMGYAFLRA WQYWLARYQT PHHRLQSGID AVLHVLDWVP
210 220 230 240 250
VRLAGVVYAL IGHGEKALPA WFASLGDFHT SQYQVLTRLA QFSLAREPHV
260 270 280
DKVETPKAAV SMAKKTSFVV VVVIALLTIY GALV
Length:284
Mass (Da):32,122
Last modified:December 6, 2005 - v1
Checksum:iC92C05B2DFE0D6AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15237 Genomic DNA. Translation: CAA33315.1.
U00096 Genomic DNA. Translation: AAC73222.1.
AP009048 Genomic DNA. Translation: BAB96680.1.
PIRiS05570.
RefSeqiNP_414653.1. NC_000913.3.
WP_000172005.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73222; AAC73222; b0111.
BAB96680; BAB96680; BAB96680.
GeneIDi946678.
KEGGiecj:JW0107.
eco:b0111.
PATRICi32115323. VBIEscCol129921_0113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15237 Genomic DNA. Translation: CAA33315.1.
U00096 Genomic DNA. Translation: AAC73222.1.
AP009048 Genomic DNA. Translation: BAB96680.1.
PIRiS05570.
RefSeqiNP_414653.1. NC_000913.3.
WP_000172005.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AE14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259732. 5 interactions.
DIPiDIP-47964N.
IntActiP0AE14. 2 interactions.
STRINGi511145.b0111.

Protein family/group databases

TCDBi9.B.125.1.1. the ampe/cobd (ampe/cobd) family.

Proteomic databases

PaxDbiP0AE14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73222; AAC73222; b0111.
BAB96680; BAB96680; BAB96680.
GeneIDi946678.
KEGGiecj:JW0107.
eco:b0111.
PATRICi32115323. VBIEscCol129921_0113.

Organism-specific databases

EchoBASEiEB0040.
EcoGeneiEG10042. ampE.

Phylogenomic databases

eggNOGiENOG4106A72. Bacteria.
COG3725. LUCA.
HOGENOMiHOG000116788.
KOiK03807.
OMAiHFSRALP.

Enzyme and pathway databases

BioCyciEcoCyc:EG10042-MONOMER.
ECOL316407:JW0107-MONOMER.

Miscellaneous databases

PROiP0AE14.

Family and domain databases

InterProiIPR031347. AmpE.
[Graphical view]
PfamiPF17113. AmpE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMPE_ECOLI
AccessioniPrimary (citable) accession number: P0AE14
Secondary accession number(s): P13017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.