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Protein

AMP nucleosidase

Gene

amn

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.UniRule annotation

Catalytic activityi

AMP + H2O = D-ribose 5-phosphate + adenine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2743-MONOMER.
ECOO157:AMN-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP nucleosidaseUniRule annotation (EC:3.2.2.4UniRule annotation)
Gene namesi
Name:amnUniRule annotation
Ordered Locus Names:Z3139, ECs2779
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558 Componenti: Chromosome UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484AMP nucleosidasePRO_0000064587Add
BLAST

Proteomic databases

PRIDEiP0AE13.

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3139.

Structurei

3D structure databases

ProteinModelPortaliP0AE13.
SMRiP0AE13. Positions 8-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AMP nucleosidase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0775.
HOGENOMiHOG000156781.
KOiK01241.
OMAiCYPFVRV.
OrthoDBiEOG67DPGS.

Family and domain databases

Gene3Di3.30.1730.10. 1 hit.
3.40.50.1580. 1 hit.
HAMAPiMF_01932. AMP_nucleosidase.
InterProiIPR011271. AMP_nucleosidase.
IPR018953. AMP_nucleoside_Pase_N.
IPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF10423. AMNp_N. 1 hit.
PF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01717. AMP-nucleosdse. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AE13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNKGSGLTP AQALDKLDAL YEQSVVALRN AIGNYITSGE LPDENARKQG
60 70 80 90 100
LFVYPSLTVT WDGSTTNPPK TRAFGRFTHA GSYTTTITRP TLFRSYLNEQ
110 120 130 140 150
LTLLYQDYGA HISVQPSQHE IPYPYVIDGS ELTLDRSMSA GLTRYFPTTE
160 170 180 190 200
LAQIGDETAD GIYHPTEFSP LSHFDARRVD FSLARLRHYT GTPVEHFQPF
210 220 230 240 250
VLFTNYTRYV DEFVRWGCSQ ILDPDSPYIA LSCAGGNWIT AETEAPEEAI
260 270 280 290 300
SDLAWKKHQM PAWHLITADG QGITLVNIGV GPSNAKTICD HLAVLRPDVW
310 320 330 340 350
LMIGHCGGLR ESQAIGDYVL AHAYLRDDHV LDAVLPPDIP IPSIAEVQRA
360 370 380 390 400
LYDATKLVSG RPGEEVKQRL RTGTVVTTDD RNWELRYSAS ALRFNLSRAV
410 420 430 440 450
AIDMESATIA AQGYRFRVPY GTLLCVSDKP LHGEIKLPGQ ANRFYEGAIS
460 470 480
EHLQIGIRAI DLLRAEGDRL HSRKLRTFNE PPFR
Length:484
Mass (Da):53,995
Last modified:December 6, 2005 - v1
Checksum:iADC2FD95CC220527
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57045.1.
BA000007 Genomic DNA. Translation: BAB36202.1.
PIRiA85823.
C90976.
RefSeqiNP_310806.1. NC_002695.1.
WP_001060244.1. NZ_LAZD01000267.1.

Genome annotation databases

EnsemblBacteriaiAAG57045; AAG57045; Z3139.
BAB36202; BAB36202; BAB36202.
GeneIDi912716.
KEGGiecs:ECs2779.
PATRICi18354950. VBIEscCol44059_2679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57045.1.
BA000007 Genomic DNA. Translation: BAB36202.1.
PIRiA85823.
C90976.
RefSeqiNP_310806.1. NC_002695.1.
WP_001060244.1. NZ_LAZD01000267.1.

3D structure databases

ProteinModelPortaliP0AE13.
SMRiP0AE13. Positions 8-484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z3139.

Proteomic databases

PRIDEiP0AE13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57045; AAG57045; Z3139.
BAB36202; BAB36202; BAB36202.
GeneIDi912716.
KEGGiecs:ECs2779.
PATRICi18354950. VBIEscCol44059_2679.

Phylogenomic databases

eggNOGiCOG0775.
HOGENOMiHOG000156781.
KOiK01241.
OMAiCYPFVRV.
OrthoDBiEOG67DPGS.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2743-MONOMER.
ECOO157:AMN-MONOMER.

Family and domain databases

Gene3Di3.30.1730.10. 1 hit.
3.40.50.1580. 1 hit.
HAMAPiMF_01932. AMP_nucleosidase.
InterProiIPR011271. AMP_nucleosidase.
IPR018953. AMP_nucleoside_Pase_N.
IPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF10423. AMNp_N. 1 hit.
PF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01717. AMP-nucleosdse. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiAMN_ECO57
AccessioniPrimary (citable) accession number: P0AE13
Secondary accession number(s): P15272, P78074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.