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P0AE13

- AMN_ECO57

UniProt

P0AE13 - AMN_ECO57

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Protein
AMP nucleosidase
Gene
amn, Z3139, ECs2779
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in regulation of AMP concentrations By similarity.

Catalytic activityi

AMP + H2O = D-ribose 5-phosphate + adenine.

Enzyme regulationi

Allosterically activated by Mg-ATP, and inactivated by inorganic phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. AMP nucleosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. AMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2743-MONOMER.
ECOO157:AMN-MONOMER.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP nucleosidase (EC:3.2.2.4)
Gene namesi
Name:amn
Ordered Locus Names:Z3139, ECs2779
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484AMP nucleosidase
PRO_0000064587Add
BLAST

Proteomic databases

PRIDEiP0AE13.

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3139.

Structurei

3D structure databases

ProteinModelPortaliP0AE13.
SMRiP0AE13. Positions 8-484.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0775.
HOGENOMiHOG000156781.
KOiK01241.
OMAiQNIPYPY.
OrthoDBiEOG67DPGS.

Family and domain databases

Gene3Di3.30.1730.10. 1 hit.
3.40.50.1580. 1 hit.
InterProiIPR011271. AMP_nucleosidase.
IPR018953. AMP_nucleoside_Pase_N.
IPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF10423. AMNp_N. 1 hit.
PF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01717. AMP-nucleosdse. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AE13-1 [UniParc]FASTAAdd to Basket

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MNNKGSGLTP AQALDKLDAL YEQSVVALRN AIGNYITSGE LPDENARKQG    50
LFVYPSLTVT WDGSTTNPPK TRAFGRFTHA GSYTTTITRP TLFRSYLNEQ 100
LTLLYQDYGA HISVQPSQHE IPYPYVIDGS ELTLDRSMSA GLTRYFPTTE 150
LAQIGDETAD GIYHPTEFSP LSHFDARRVD FSLARLRHYT GTPVEHFQPF 200
VLFTNYTRYV DEFVRWGCSQ ILDPDSPYIA LSCAGGNWIT AETEAPEEAI 250
SDLAWKKHQM PAWHLITADG QGITLVNIGV GPSNAKTICD HLAVLRPDVW 300
LMIGHCGGLR ESQAIGDYVL AHAYLRDDHV LDAVLPPDIP IPSIAEVQRA 350
LYDATKLVSG RPGEEVKQRL RTGTVVTTDD RNWELRYSAS ALRFNLSRAV 400
AIDMESATIA AQGYRFRVPY GTLLCVSDKP LHGEIKLPGQ ANRFYEGAIS 450
EHLQIGIRAI DLLRAEGDRL HSRKLRTFNE PPFR 484
Length:484
Mass (Da):53,995
Last modified:December 6, 2005 - v1
Checksum:iADC2FD95CC220527
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57045.1.
BA000007 Genomic DNA. Translation: BAB36202.1.
PIRiA85823.
C90976.
RefSeqiNP_288491.1. NC_002655.2.
NP_310806.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57045; AAG57045; Z3139.
BAB36202; BAB36202; BAB36202.
GeneIDi912716.
962041.
KEGGiece:Z3139.
ecs:ECs2779.
PATRICi18354950. VBIEscCol44059_2679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57045.1 .
BA000007 Genomic DNA. Translation: BAB36202.1 .
PIRi A85823.
C90976.
RefSeqi NP_288491.1. NC_002655.2.
NP_310806.1. NC_002695.1.

3D structure databases

ProteinModelPortali P0AE13.
SMRi P0AE13. Positions 8-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z3139.

Proteomic databases

PRIDEi P0AE13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG57045 ; AAG57045 ; Z3139 .
BAB36202 ; BAB36202 ; BAB36202 .
GeneIDi 912716.
962041.
KEGGi ece:Z3139.
ecs:ECs2779.
PATRICi 18354950. VBIEscCol44059_2679.

Phylogenomic databases

eggNOGi COG0775.
HOGENOMi HOG000156781.
KOi K01241.
OMAi QNIPYPY.
OrthoDBi EOG67DPGS.

Enzyme and pathway databases

UniPathwayi UPA00588 ; UER00646 .
BioCyci ECOL386585:GJFA-2743-MONOMER.
ECOO157:AMN-MONOMER.

Family and domain databases

Gene3Di 3.30.1730.10. 1 hit.
3.40.50.1580. 1 hit.
InterProi IPR011271. AMP_nucleosidase.
IPR018953. AMP_nucleoside_Pase_N.
IPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view ]
PANTHERi PTHR21234. PTHR21234. 1 hit.
Pfami PF10423. AMNp_N. 1 hit.
PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01717. AMP-nucleosdse. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiAMN_ECO57
AccessioniPrimary (citable) accession number: P0AE13
Secondary accession number(s): P15272, P78074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

AMP nucleosidase binds AMP at the catalytic site, Mg-ATP at an allosteric regulatory site, and inorganic phosphate also at a regulatory site By similarity.

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

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