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P0AE13

- AMN_ECO57

UniProt

P0AE13 - AMN_ECO57

Protein

AMP nucleosidase

Gene

amn

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Involved in regulation of AMP concentrations.By similarity

    Catalytic activityi

    AMP + H2O = D-ribose 5-phosphate + adenine.

    Enzyme regulationi

    Allosterically activated by Mg-ATP, and inactivated by inorganic phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. AMP nucleosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. AMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-2743-MONOMER.
    ECOO157:AMN-MONOMER.
    UniPathwayiUPA00588; UER00646.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP nucleosidase (EC:3.2.2.4)
    Gene namesi
    Name:amn
    Ordered Locus Names:Z3139, ECs2779
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484AMP nucleosidasePRO_0000064587Add
    BLAST

    Proteomic databases

    PRIDEiP0AE13.

    Interactioni

    Protein-protein interaction databases

    STRINGi155864.Z3139.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AE13.
    SMRiP0AE13. Positions 8-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0775.
    HOGENOMiHOG000156781.
    KOiK01241.
    OMAiQNIPYPY.
    OrthoDBiEOG67DPGS.

    Family and domain databases

    Gene3Di3.30.1730.10. 1 hit.
    3.40.50.1580. 1 hit.
    InterProiIPR011271. AMP_nucleosidase.
    IPR018953. AMP_nucleoside_Pase_N.
    IPR018017. Nucleoside_phosphorylase.
    IPR000845. Nucleoside_phosphorylase_d.
    [Graphical view]
    PANTHERiPTHR21234. PTHR21234. 1 hit.
    PfamiPF10423. AMNp_N. 1 hit.
    PF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01717. AMP-nucleosdse. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0AE13-1 [UniParc]FASTAAdd to Basket

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    MNNKGSGLTP AQALDKLDAL YEQSVVALRN AIGNYITSGE LPDENARKQG    50
    LFVYPSLTVT WDGSTTNPPK TRAFGRFTHA GSYTTTITRP TLFRSYLNEQ 100
    LTLLYQDYGA HISVQPSQHE IPYPYVIDGS ELTLDRSMSA GLTRYFPTTE 150
    LAQIGDETAD GIYHPTEFSP LSHFDARRVD FSLARLRHYT GTPVEHFQPF 200
    VLFTNYTRYV DEFVRWGCSQ ILDPDSPYIA LSCAGGNWIT AETEAPEEAI 250
    SDLAWKKHQM PAWHLITADG QGITLVNIGV GPSNAKTICD HLAVLRPDVW 300
    LMIGHCGGLR ESQAIGDYVL AHAYLRDDHV LDAVLPPDIP IPSIAEVQRA 350
    LYDATKLVSG RPGEEVKQRL RTGTVVTTDD RNWELRYSAS ALRFNLSRAV 400
    AIDMESATIA AQGYRFRVPY GTLLCVSDKP LHGEIKLPGQ ANRFYEGAIS 450
    EHLQIGIRAI DLLRAEGDRL HSRKLRTFNE PPFR 484
    Length:484
    Mass (Da):53,995
    Last modified:December 6, 2005 - v1
    Checksum:iADC2FD95CC220527
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57045.1.
    BA000007 Genomic DNA. Translation: BAB36202.1.
    PIRiA85823.
    C90976.
    RefSeqiNP_288491.1. NC_002655.2.
    NP_310806.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG57045; AAG57045; Z3139.
    BAB36202; BAB36202; BAB36202.
    GeneIDi912716.
    962041.
    KEGGiece:Z3139.
    ecs:ECs2779.
    PATRICi18354950. VBIEscCol44059_2679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57045.1 .
    BA000007 Genomic DNA. Translation: BAB36202.1 .
    PIRi A85823.
    C90976.
    RefSeqi NP_288491.1. NC_002655.2.
    NP_310806.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0AE13.
    SMRi P0AE13. Positions 8-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z3139.

    Proteomic databases

    PRIDEi P0AE13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG57045 ; AAG57045 ; Z3139 .
    BAB36202 ; BAB36202 ; BAB36202 .
    GeneIDi 912716.
    962041.
    KEGGi ece:Z3139.
    ecs:ECs2779.
    PATRICi 18354950. VBIEscCol44059_2679.

    Phylogenomic databases

    eggNOGi COG0775.
    HOGENOMi HOG000156781.
    KOi K01241.
    OMAi QNIPYPY.
    OrthoDBi EOG67DPGS.

    Enzyme and pathway databases

    UniPathwayi UPA00588 ; UER00646 .
    BioCyci ECOL386585:GJFA-2743-MONOMER.
    ECOO157:AMN-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1730.10. 1 hit.
    3.40.50.1580. 1 hit.
    InterProi IPR011271. AMP_nucleosidase.
    IPR018953. AMP_nucleoside_Pase_N.
    IPR018017. Nucleoside_phosphorylase.
    IPR000845. Nucleoside_phosphorylase_d.
    [Graphical view ]
    PANTHERi PTHR21234. PTHR21234. 1 hit.
    Pfami PF10423. AMNp_N. 1 hit.
    PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01717. AMP-nucleosdse. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiAMN_ECO57
    AccessioniPrimary (citable) accession number: P0AE13
    Secondary accession number(s): P15272, P78074
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    AMP nucleosidase binds AMP at the catalytic site, Mg-ATP at an allosteric regulatory site, and inorganic phosphate also at a regulatory site.By similarity

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3