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Protein

Sec translocon accessory complex subunit YajC

Gene

yajC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes (PubMed:27435098). The SecYEG complex is essential for assembly of a number of proteins and complexes, assembly is facilitated in the presence of the SecDF-YajC-YidC subcomplex (PubMed:27435098).1 Publication

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11096-MONOMER

Protein family/group databases

TCDBi3.A.5.1.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sec translocon accessory complex subunit YajC
Gene namesi
Name:yajC
Ordered Locus Names:b0407, JW0397
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11096 yajC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cell envelope Sec protein transport complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000970131 – 110Sec translocon accessory complex subunit YajCAdd BLAST110

Proteomic databases

EPDiP0ADZ7
PaxDbiP0ADZ7
PRIDEiP0ADZ7

Interactioni

Subunit structurei

Part of the SecDF-YidC-YajC translocase complex; YajC is also present in a homooligomeric complex in excess of the other components (PubMed:16079137). The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL) (PubMed:27435098). The stoichiometry of the super complex may be SecYEG:YidC:SecDF 4:3:1, YajC is in the reconstituted complex (with SecDF) but as no antibody is available it could not be quantified (PubMed:27435098).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
acrBP312242EBI-1130723,EBI-551006

Protein-protein interaction databases

BioGridi4263532, 415 interactors
ComplexPortaliCPX-1095 Holo-translocon SecYEG-SecDF-YajC-YidC complex
DIPiDIP-29531N
IntActiP0ADZ7, 2 interactors
STRINGi316385.ECDH10B_0363

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 37Combined sources16
Helixi39 – 49Combined sources11
Helixi52 – 54Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RDDX-ray3.50B19-55[»]
ProteinModelPortaliP0ADZ7
SMRiP0ADZ7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ADZ7

Family & Domainsi

Sequence similaritiesi

Belongs to the YajC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105VIE Bacteria
COG1862 LUCA
HOGENOMiHOG000018859
InParanoidiP0ADZ7
KOiK03210
OMAiYSLIIML
PhylomeDBiP0ADZ7

Family and domain databases

InterProiView protein in InterPro
IPR003849 Preprotein_translocase_YajC
PANTHERiPTHR33909 PTHR33909, 1 hit
PfamiView protein in Pfam
PF02699 YajC, 1 hit
PRINTSiPR01853 YAJCTRNLCASE
SMARTiView protein in SMART
SM01323 YajC, 1 hit
TIGRFAMsiTIGR00739 yajC, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFISDAVA ATGAPAQGSP MSLILMLVVF GLIFYFMILR PQQKRTKEHK
60 70 80 90 100
KLMDSIAKGD EVLTNGGLVG RVTKVAENGY IAIALNDTTE VVIKRDFVAA
110
VLPKGTMKAL
Length:110
Mass (Da):11,887
Last modified:December 6, 2005 - v1
Checksum:i8E90AF51F0205306
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82A → R in CAA39633 (PubMed:2170107).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56175 Genomic DNA Translation: CAA39633.1
M63939 Genomic DNA Translation: AAA24668.1
S68715 Genomic DNA Translation: AAC60468.1
U82664 Genomic DNA Translation: AAB40163.1
U00096 Genomic DNA Translation: AAC73510.1
AP009048 Genomic DNA Translation: BAE76187.1
PIRiD38530
RefSeqiNP_414941.1, NC_000913.3
WP_000007629.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73510; AAC73510; b0407
BAE76187; BAE76187; BAE76187
GeneIDi945374
KEGGiecj:JW0397
eco:b0407
PATRICifig|1411691.4.peg.1870

Similar proteinsi

Entry informationi

Entry nameiYAJC_ECOLI
AccessioniPrimary (citable) accession number: P0ADZ7
Secondary accession number(s): P19677, Q2MC19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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