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Protein

Ribosomal RNA small subunit methyltransferase D

Gene

rsmD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + guanine(966) in 16S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine(966) in 16S rRNA.

GO - Molecular functioni

GO - Biological processi

  • rRNA base methylation Source: EcoCyc

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:EG10343-MONOMER
MetaCyc:EG10343-MONOMER
BRENDAi2.1.1.171 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase D (EC:2.1.1.171)
Alternative name(s):
16S rRNA m2G966 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase
Gene namesi
Name:rsmD
Synonyms:yhhF
Ordered Locus Names:b3465, JW3430
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10343 rsmD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001695481 – 198Ribosomal RNA small subunit methyltransferase DAdd BLAST198

Proteomic databases

PaxDbiP0ADX9
PRIDEiP0ADX9

2D gel databases

SWISS-2DPAGEiP0ADX9

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4262500, 62 interactors
DIPiDIP-48275N
IntActiP0ADX9, 6 interactors
STRINGi316385.ECDH10B_3639

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 13Combined sources3
Helixi17 – 19Combined sources3
Beta strandi23 – 25Combined sources3
Helixi37 – 51Combined sources15
Beta strandi55 – 58Combined sources4
Helixi65 – 72Combined sources8
Beta strandi76 – 81Combined sources6
Helixi85 – 97Combined sources13
Beta strandi102 – 106Combined sources5
Helixi110 – 114Combined sources5
Beta strandi121 – 126Combined sources6
Beta strandi129 – 131Combined sources3
Turni132 – 134Combined sources3
Helixi135 – 144Combined sources10
Beta strandi148 – 159Combined sources12
Helixi160 – 162Combined sources3
Beta strandi171 – 179Combined sources9
Beta strandi182 – 189Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FPOX-ray2.05A/B/C/D/E/F1-198[»]
ProteinModelPortaliP0ADX9
SMRiP0ADX9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ADX9

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4106H78 Bacteria
COG0742 LUCA
HOGENOMiHOG000050676
InParanoidiP0ADX9
KOiK08316
OMAiFNWLMPY
PhylomeDBiP0ADX9

Family and domain databases

InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004398 RNA_MeTrfase_RsmD
IPR029063 SAM-dependent_MTases
PIRSFiPIRSF004553 CHP00095, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00095 TIGR00095, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKPNHSGSG QIRIIGGQWR GRKLPVPDSP GLRPTTDRVR ETLFNWLAPV
60 70 80 90 100
IVDAQCLDCF AGSGALGLEA LSRYAAGATL IEMDRAVSQQ LIKNLATLKA
110 120 130 140 150
GNARVVNSNA MSFLAQKGTP HNIVFVDPPF RRGLLEETIN LLEDNGWLAD
160 170 180 190
EALIYVESEV ENGLPTVPAN WSLHREKVAG QVAYRLYQRE AQGESDAD
Length:198
Mass (Da):21,678
Last modified:December 6, 2005 - v1
Checksum:i04FB9D9DAF972605
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04398 Genomic DNA Translation: CAA27983.1
U00039 Genomic DNA Translation: AAB18440.1
U00096 Genomic DNA Translation: AAC76490.1
AP009048 Genomic DNA Translation: BAE77828.1
PIRiS03129 QQECX3
RefSeqiNP_417922.1, NC_000913.3
WP_000743193.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76490; AAC76490; b3465
BAE77828; BAE77828; BAE77828
GeneIDi947977
KEGGiecj:JW3430
eco:b3465
PATRICifig|511145.12.peg.3564

Similar proteinsi

Entry informationi

Entry nameiRSMD_ECOLI
AccessioniPrimary (citable) accession number: P0ADX9
Secondary accession number(s): P10120, Q2M7C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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