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Protein

Protein YhcC

Gene

yhcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In vitro, can cleave S-adenosyl-L-methionine into methionine and 5'-deoxyadenosine (AdoH).1 Publication

Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi33 – 331Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi45 – 451Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi48 – 481Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:G7669-MONOMER.
ECOL316407:JW3178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YhcCCurated
Gene namesi
Name:yhcC
Ordered Locus Names:b3211, JW3178
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12809. yhcC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Protein YhcCPRO_0000169481Add
BLAST

Proteomic databases

PaxDbiP0ADW6.
PRIDEiP0ADW6.

Interactioni

Protein-protein interaction databases

BioGridi4262426. 7 interactions.
DIPiDIP-48274N.
IntActiP0ADW6. 10 interactions.
MINTiMINT-1252681.
STRINGi511145.b3211.

Structurei

3D structure databases

ProteinModelPortaliP0ADW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the radical SAM superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105N5T. Bacteria.
COG1242. LUCA.
HOGENOMiHOG000027270.
InParanoidiP0ADW6.
KOiK07139.
OMAiGGCTYCN.
OrthoDBiEOG6TFCS0.
PhylomeDBiP0ADW6.

Family and domain databases

Gene3Di3.80.30.20. 1 hit.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR032432. Radical_SAM_C.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR005911. YhcC-like.
[Graphical view]
PANTHERiPTHR11135:SF1. PTHR11135:SF1. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF16199. Radical_SAM_C. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01212. TIGR01212. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ADW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQKLVNMF GGDLTRRYGQ KVHKLTLHGG FSCPNRDGTI GRGGCTFCNV
60 70 80 90 100
ASFADEAQQH RSIAEQLAHQ ANLVNRAKRY LAYFQAYTST FAEVQVLRSM
110 120 130 140 150
YQQAVSQANI VGLCVGTRPD CVPDAVLDLL CEYKDQGYEV WLELGLQTAH
160 170 180 190 200
DKTLHRINRG HDFACYQRTT QLARQRGLKV CSHLIVGLPG EGQAECLQTL
210 220 230 240 250
ERVVETGVDG IKLHPLHIVK GSIMAKAWEA GRLNGIELED YTLTAGEMIR
260 270 280 290 300
HTPPEVIYHR ISASARRPTL LAPLWCENRW TGMVELDRYL NEHGVQGSAL

GRPWLPPTE
Length:309
Mass (Da):34,607
Last modified:December 6, 2005 - v1
Checksum:i61B3187BB77CA1A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 252KL → NV in L20253 (PubMed:7901196).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58013.1. Sequence problems.
U00096 Genomic DNA. Translation: AAC76243.1.
AP009048 Genomic DNA. Translation: BAE77255.1.
L20253 Genomic DNA. No translation available.
PIRiE65112.
RefSeqiNP_417678.1. NC_000913.3.
WP_001299745.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76243; AAC76243; b3211.
BAE77255; BAE77255; BAE77255.
GeneIDi947733.
KEGGiecj:JW3178.
eco:b3211.
PATRICi32121842. VBIEscCol129921_3305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58013.1. Sequence problems.
U00096 Genomic DNA. Translation: AAC76243.1.
AP009048 Genomic DNA. Translation: BAE77255.1.
L20253 Genomic DNA. No translation available.
PIRiE65112.
RefSeqiNP_417678.1. NC_000913.3.
WP_001299745.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ADW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262426. 7 interactions.
DIPiDIP-48274N.
IntActiP0ADW6. 10 interactions.
MINTiMINT-1252681.
STRINGi511145.b3211.

Proteomic databases

PaxDbiP0ADW6.
PRIDEiP0ADW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76243; AAC76243; b3211.
BAE77255; BAE77255; BAE77255.
GeneIDi947733.
KEGGiecj:JW3178.
eco:b3211.
PATRICi32121842. VBIEscCol129921_3305.

Organism-specific databases

EchoBASEiEB2660.
EcoGeneiEG12809. yhcC.

Phylogenomic databases

eggNOGiENOG4105N5T. Bacteria.
COG1242. LUCA.
HOGENOMiHOG000027270.
InParanoidiP0ADW6.
KOiK07139.
OMAiGGCTYCN.
OrthoDBiEOG6TFCS0.
PhylomeDBiP0ADW6.

Enzyme and pathway databases

BioCyciEcoCyc:G7669-MONOMER.
ECOL316407:JW3178-MONOMER.

Miscellaneous databases

PROiP0ADW6.

Family and domain databases

Gene3Di3.80.30.20. 1 hit.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR032432. Radical_SAM_C.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR005911. YhcC-like.
[Graphical view]
PANTHERiPTHR11135:SF1. PTHR11135:SF1. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF16199. Radical_SAM_C. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01212. TIGR01212. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Regulation of the gltBDF operon of Escherichia coli: how is a leucine-insensitive operon regulated by the leucine-responsive regulatory protein?"
    Ernsting B.R., Denninger J.W., Blumenthal R.M., Matthews R.G.
    J. Bacteriol. 175:7160-7169(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "An integrative computational model for large-scale identification of metalloproteins in microbial genomes: a focus on iron-sulfur cluster proteins."
    Estellon J., Ollagnier de Choudens S., Smadja M., Fontecave M., Vandenbrouck Y.
    Metallomics 6:1913-1930(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COFACTOR.

Entry informationi

Entry nameiYHCC_ECOLI
AccessioniPrimary (citable) accession number: P0ADW6
Secondary accession number(s): P45476, Q2M901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 13, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.