Reviewed, UniProtKB/Swiss-Prot P0ADV9 (LPTC_ECOLI)

Names and origin

Protein names

Recommended name:
    Lipopolysaccharide export system protein lptC

Gene names

Name:	lptC
Synonyms:	yrbK
Ordered Locus Names:	b3199, JW3166

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Ref.4
Subcellular location	Cell inner membrane; Single-pass membrane protein. Ref.4
Sequence similarities	Belongs to the lptC family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
nadE	P18843	1	EBI-1131969,EBI-548960

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Lipopolysaccharide export system protein lptC		PRO_0000169470
Regions
	Transmembrane	7 – 25	19	Potential

Sequences

	Sequence		Length	Mass (Da)
	P0ADV9-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: F6BAE79EA232CD95	FASTA	191	21,703
	10 20 30 40 50 60 MSKARRWVII VLSLAVLVMI GINMAEKDDT AQVVVNNNDP TYKSEHTDTL VYNPEGALSY 70 80 90 100 110 120 RLIAQHVEYY SDQAVSWFTQ PVLTTFDKDK IPTWSVKADK AKLTNDRMLY LYGHVEVNAL 130 140 150 160 170 180 VPDSQLRRIT TDNAQINLVT QDVTSEDLVT LYGTTFNSSG LKMRGNLRSK NAELIEKVRT 190 SYEIQNKQTQ P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli. Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant." Powell B.S., Court D.L., Inada T., Nakamura Y., Michotey V., Cui X., Reizer A., Saier M.H. Jr., Reizer J. J. Biol. Chem. 270:4822-4839(1995) [PubMed: 7876255] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-191. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli." Sperandeo P., Lau F.K., Carpentieri A., De Castro C., Molinaro A., Deho G., Silhavy T.J., Polissi A. J. Bacteriol. 190:4460-4469(2008) [PubMed: 18424520] [Abstract] Cited for: FUNCTION IN LIPOPOLYSACCHARIDE TRANSPORT, SUBCELLULAR LOCATION. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18997 Genomic DNA. Translation: AAA58001.1. U00096 Genomic DNA. Translation: AAC76231.1. AP009048 Genomic DNA. Translation: BAE77243.1. U12684 Genomic DNA. No translation available.
PIR	A65111.
RefSeq	AP_003742.1. NP_417666.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P0ADV9. 1 interaction.
Genome annotation databases
GeneID	947722.
GenomeReviews	Gene locus JW3166 in contig AP009048_GR. Gene locus b3199 in contig U00096_GR.
KEGG	ecj:JW3166. eco:b3199.
Organism-specific databases
EchoBASE	EB2657.
EcoGene	EG12806. lptC.
CMR	Search...
Phylogenomic databases
HOGENOM	P0ADV9.
OMA	P0ADV9. VQGRYET.
Enzyme and pathway databases
BioCyc	EcoCyc:G7664-MON.
Family and domain databases
InterPro	IPR010664. DUF1239. [Graphical view]
Pfam	PF06835. DUF1239. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPTC_ECOLI

Accession

Primary (citable) accession number: P0ADV9
Secondary accession number(s): P45397, Q2M913

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)