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P0ADV9 (LPTC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipopolysaccharide export system protein LptC
Gene names
Name:lptC
Synonyms:yrbK
Ordered Locus Names:b3199, JW3166
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. It facilitates the transfer of LPS from the inner membrane to a periplasmic chaperone, LptA. Ref.4 Ref.5 Ref.6

Subcellular location

Cell inner membrane; Single-pass membrane protein Ref.5 Ref.6.

Disruption phenotype

Leads to irreversible cell damage, growth arrest and an extreme sensitivity to SDS. Ref.4

Sequence similarities

Belongs to the LptC family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself4EBI-1131969,EBI-1131969
lptAP0ADV13EBI-1131969,EBI-1132001

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Lipopolysaccharide export system protein LptC
PRO_0000169470

Regions

Transmembrane7 – 2519Helical; Potential

Secondary structure

.......................... 191
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0ADV9 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: F6BAE79EA232CD95

FASTA19121,703
        10         20         30         40         50         60 
MSKARRWVII VLSLAVLVMI GINMAEKDDT AQVVVNNNDP TYKSEHTDTL VYNPEGALSY 

        70         80         90        100        110        120 
RLIAQHVEYY SDQAVSWFTQ PVLTTFDKDK IPTWSVKADK AKLTNDRMLY LYGHVEVNAL 

       130        140        150        160        170        180 
VPDSQLRRIT TDNAQINLVT QDVTSEDLVT LYGTTFNSSG LKMRGNLRSK NAELIEKVRT 

       190 
SYEIQNKQTQ P 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli. Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant."
Powell B.S., Court D.L., Inada T., Nakamura Y., Michotey V., Cui X., Reizer A., Saier M.H. Jr., Reizer J.
J. Biol. Chem. 270:4822-4839(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-191.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Non-essential KDO biosynthesis and new essential cell envelope biogenesis genes in the Escherichia coli yrbG-yhbG locus."
Sperandeo P., Pozzi C., Deho G., Polissi A.
Res. Microbiol. 157:547-558(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN LPS BIOSYNTHESIS, DISRUPTION PHENOTYPE.
[5]"Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli."
Sperandeo P., Lau F.K., Carpentieri A., De Castro C., Molinaro A., Deho G., Silhavy T.J., Polissi A.
J. Bacteriol. 190:4460-4469(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN LIPOPOLYSACCHARIDE TRANSPORT, SUBCELLULAR LOCATION.
Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
[6]"Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coli."
Tran A.X., Dong C., Whitfield C.
J. Biol. Chem. 285:33529-33539(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 23-191, FUNCTION IN LIPOPOLYSACCHARIDE TRANSPORT, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18997 Genomic DNA. Translation: AAA58001.1.
U00096 Genomic DNA. Translation: AAC76231.1.
AP009048 Genomic DNA. Translation: BAE77243.1.
U12684 Genomic DNA. No translation available.
PIRA65111.
RefSeqNP_417666.1. NC_000913.3.
YP_491384.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3MY2X-ray2.20A23-191[»]
4B54X-ray2.80A/B24-191[»]
ProteinModelPortalP0ADV9.
SMRP0ADV9. Positions 59-184.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-12912N.
IntActP0ADV9. 3 interactions.
MINTMINT-7137017.
STRING511145.b3199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC76231; AAC76231; b3199.
BAE77243; BAE77243; BAE77243.
GeneID12930285.
947722.
KEGGecj:Y75_p3119.
eco:b3199.
PATRIC32121818. VBIEscCol129921_3293.

Organism-specific databases

EchoBASEEB2657.
EcoGeneEG12806. lptC.

Phylogenomic databases

eggNOGCOG3117.
HOGENOMHOG000125239.
KOK11719.
OMAMRGNLRN.
OrthoDBEOG6W7212.
ProtClustDBPRK10893.

Enzyme and pathway databases

BioCycEcoCyc:G7664-MONOMER.
ECOL316407:JW3166-MONOMER.
MetaCyc:G7664-MONOMER.

Gene expression databases

GenevestigatorP0ADV9.

Family and domain databases

InterProIPR010664. LipoPS_assembly_LptC-rel.
IPR026265. LptC.
[Graphical view]
PfamPF06835. LptC. 1 hit.
[Graphical view]
PIRSFPIRSF028513. LptC. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP0ADV9.
PROP0ADV9.

Entry information

Entry nameLPTC_ECOLI
AccessionPrimary (citable) accession number: P0ADV9
Secondary accession number(s): P45397, Q2M913
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene