Lipopolysaccharide export system protein LptC - Escherichia coli (strain K12)

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P0ADV9 (LPTC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Lipopolysaccharide export system protein LptC

Gene names

Name:	lptC
Synonyms:	yrbK
Ordered Locus Names:	b3199, JW3166

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. It facilitates the transfer of LPS from the inner membrane to a periplasmic chaperone, LptA. Ref.4 Ref.5 Ref.6
Subcellular location	Cell inner membrane; Single-pass membrane protein Ref.5 Ref.6.
Disruption phenotype	Leads to irreversible cell damage, growth arrest and an extreme sensitivity to SDS. Ref.4
Sequence similarities	Belongs to the LptC family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipopolysaccharide transport Inferred from mutant phenotype Ref.5. Source: EcoCyc
Cellular_component	integral to plasma membrane Inferred from direct assay Ref.6. Source: EcoCyc outer membrane-bounded periplasmic space Inferred from direct assay Ref.6. Source: EcoCyc
Molecular_function	glycolipid transporter activity Inferred from mutant phenotype Ref.4. Source: EcoCyc lipopolysaccharide transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-1131969,EBI-1131969
lptA	P0ADV1	2	EBI-1131969,EBI-1132001

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 191

191

Lipopolysaccharide export system protein LptC

PRO_0000169470

Regions

Transmembrane

7 – 25

Helical; Potential

Secondary structure

191

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P0ADV9 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: F6BAE79EA232CD95
Show »

FASTA

191

21,703

        10         20         30         40         50         60 
MSKARRWVII VLSLAVLVMI GINMAEKDDT AQVVVNNNDP TYKSEHTDTL VYNPEGALSY 

        70         80         90        100        110        120 
RLIAQHVEYY SDQAVSWFTQ PVLTTFDKDK IPTWSVKADK AKLTNDRMLY LYGHVEVNAL 

       130        140        150        160        170        180 
VPDSQLRRIT TDNAQINLVT QDVTSEDLVT LYGTTFNSSG LKMRGNLRSK NAELIEKVRT 

       190 
SYEIQNKQTQ P

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli. Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant." Powell B.S., Court D.L., Inada T., Nakamura Y., Michotey V., Cui X., Reizer A., Saier M.H. Jr., Reizer J. J. Biol. Chem. 270:4822-4839(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-191. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Non-essential KDO biosynthesis and new essential cell envelope biogenesis genes in the Escherichia coli yrbG-yhbG locus." Sperandeo P., Pozzi C., Deho G., Polissi A. Res. Microbiol. 157:547-558(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN LPS BIOSYNTHESIS, DISRUPTION PHENOTYPE.
[5]	"Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli." Sperandeo P., Lau F.K., Carpentieri A., De Castro C., Molinaro A., Deho G., Silhavy T.J., Polissi A. J. Bacteriol. 190:4460-4469(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN LIPOPOLYSACCHARIDE TRANSPORT, SUBCELLULAR LOCATION. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
[6]	"Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coli." Tran A.X., Dong C., Whitfield C. J. Biol. Chem. 285:33529-33539(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 23-191, FUNCTION IN LIPOPOLYSACCHARIDE TRANSPORT, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U18997 Genomic DNA. Translation: AAA58001.1.
U00096 Genomic DNA. Translation: AAC76231.1.
AP009048 Genomic DNA. Translation: BAE77243.1.
U12684 Genomic DNA. No translation available.

PIR

A65111.

RefSeq

NP_417666.1. NC_000913.2.
YP_491384.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3MY2	X-ray	2.20	A	23-191	[»]
4B54	X-ray	2.80	A/B	24-191	[»]

ProteinModelPortal

P0ADV9.

SMR

P0ADV9. Positions 59-184.

ModBase

Search...

Protein-protein interaction databases

IntAct

P0ADV9. 2 interactions.

STRING

511145.b3199.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC76231; AAC76231; b3199.
BAE77243; BAE77243; BAE77243.

GeneID

12930285.
947722.

KEGG

ecj:Y75_p3119.
eco:b3199.

PATRIC

32121818. VBIEscCol129921_3293.

Organism-specific databases

EchoBASE

EB2657.

EcoGene

EG12806. lptC.

Phylogenomic databases

eggNOG

COG3117.

HOGENOM

HOG000125239.

K11719.

OMA

MRGNLRN.

ProtClustDB

PRK10893.

Enzyme and pathway databases

BioCyc

EcoCyc:G7664-MONOMER.
ECOL316407:JW3166-MONOMER.

Gene expression databases

Genevestigator

P0ADV9.

Family and domain databases

InterPro

IPR010664. LipoPS_assembly_LptC-rel.
IPR026265. LptC.
[Graphical view]

Pfam

PF06835. LptC. 1 hit.
[Graphical view]

PIRSF

PIRSF028513. LptC. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P0ADV9.

Entry information

Entry name

LPTC_ECOLI

Accession

Primary (citable) accession number: P0ADV9
Secondary accession number(s): P45397, Q2M913

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents