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Protein

Probable phospholipid-binding protein MlaC

Gene

mlaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane.1 Publication

GO - Molecular functioni

  • phospholipid binding Source: EcoCyc

GO - Biological processi

  • phospholipid transport Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7659-MONOMER.
ECOL316407:JW3159-MONOMER.

Protein family/group databases

TCDBi3.A.1.27.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-binding protein MlaCCurated
Gene namesi
Name:mlaC
Synonyms:yrbC
Ordered Locus Names:b3192, JW3159
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12798. mlaC.

Subcellular locationi

  • Periplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 211190Probable phospholipid-binding protein MlaCPRO_0000013916Add
BLAST

Proteomic databases

PaxDbiP0ADV7.
PRIDEiP0ADV7.

2D gel databases

SWISS-2DPAGEP0ADV7.

Interactioni

Protein-protein interaction databases

BioGridi4262983. 8 interactions.
IntActiP0ADV7. 2 interactions.
STRINGi511145.b3192.

Structurei

3D structure databases

ProteinModelPortaliP0ADV7.
SMRiP0ADV7. Positions 47-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MlaC/ttg2D family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E3I. Bacteria.
COG2854. LUCA.
HOGENOMiHOG000284031.
InParanoidiP0ADV7.
KOiK07323.
OMAiAEKTFTR.
PhylomeDBiP0ADV7.

Family and domain databases

Gene3Di1.10.10.640. 2 hits.
3.10.450.50. 2 hits.
InterProiIPR008869. MlaC/ttg2D.
IPR032710. NTF2-like_dom.
IPR023094. Tol_tolerance_alpha.
[Graphical view]
PfamiPF05494. MlaC. 1 hit.
[Graphical view]
PIRSFiPIRSF004649. MlaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ADV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRLMMVAL LVIAPLSAAT AADQTNPYKL MDEAAQKTFD RLKNEQPQIR
60 70 80 90 100
ANPDYLRTIV DQELLPYVQV KYAGALVLGQ YYKSATPAQR EAYFAAFREY
110 120 130 140 150
LKQAYGQALA MYHGQTYQIA PEQPLGDKTI VPIRVTIIDP NGRPPVRLDF
160 170 180 190 200
QWRKNSQTGN WQAYDMIAEG VSMITTKQNE WGTLLRTKGI DGLTAQLKSI
210
SQQKITLEEK K
Length:211
Mass (Da):23,963
Last modified:December 6, 2005 - v1
Checksum:iA8F22EDFB0830763
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57993.1.
U00096 Genomic DNA. Translation: AAC76224.1.
AP009048 Genomic DNA. Translation: BAE77236.1.
PIRiB65110.
RefSeqiNP_417659.1. NC_000913.3.
WP_000476487.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76224; AAC76224; b3192.
BAE77236; BAE77236; BAE77236.
GeneIDi947710.
KEGGiecj:JW3159.
eco:b3192.
PATRICi32121804. VBIEscCol129921_3286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57993.1.
U00096 Genomic DNA. Translation: AAC76224.1.
AP009048 Genomic DNA. Translation: BAE77236.1.
PIRiB65110.
RefSeqiNP_417659.1. NC_000913.3.
WP_000476487.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ADV7.
SMRiP0ADV7. Positions 47-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262983. 8 interactions.
IntActiP0ADV7. 2 interactions.
STRINGi511145.b3192.

Protein family/group databases

TCDBi3.A.1.27.3. the atp-binding cassette (abc) superfamily.

2D gel databases

SWISS-2DPAGEP0ADV7.

Proteomic databases

PaxDbiP0ADV7.
PRIDEiP0ADV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76224; AAC76224; b3192.
BAE77236; BAE77236; BAE77236.
GeneIDi947710.
KEGGiecj:JW3159.
eco:b3192.
PATRICi32121804. VBIEscCol129921_3286.

Organism-specific databases

EchoBASEiEB2650.
EcoGeneiEG12798. mlaC.

Phylogenomic databases

eggNOGiENOG4105E3I. Bacteria.
COG2854. LUCA.
HOGENOMiHOG000284031.
InParanoidiP0ADV7.
KOiK07323.
OMAiAEKTFTR.
PhylomeDBiP0ADV7.

Enzyme and pathway databases

BioCyciEcoCyc:G7659-MONOMER.
ECOL316407:JW3159-MONOMER.

Miscellaneous databases

PROiP0ADV7.

Family and domain databases

Gene3Di1.10.10.640. 2 hits.
3.10.450.50. 2 hits.
InterProiIPR008869. MlaC/ttg2D.
IPR032710. NTF2-like_dom.
IPR023094. Tol_tolerance_alpha.
[Graphical view]
PfamiPF05494. MlaC. 1 hit.
[Graphical view]
PIRSFiPIRSF004649. MlaC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMLAC_ECOLI
AccessioniPrimary (citable) accession number: P0ADV7
Secondary accession number(s): P45390, Q2M920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.