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Protein

Probable phospholipid-binding protein MlaC

Gene

mlaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane.1 Publication

GO - Biological processi

  • phospholipid transport Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7659-MONOMER.

Protein family/group databases

TCDBi3.A.1.27.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-binding protein MlaCCurated
Gene namesi
Name:mlaC
Synonyms:yrbC
Ordered Locus Names:b3192, JW3159
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12798. mlaC.

Subcellular locationi

  • Periplasm 1 Publication

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001391622 – 211Probable phospholipid-binding protein MlaCAdd BLAST190

Proteomic databases

PaxDbiP0ADV7.
PRIDEiP0ADV7.

2D gel databases

SWISS-2DPAGEiP0ADV7.

Interactioni

Protein-protein interaction databases

BioGridi4262983. 8 interactors.
IntActiP0ADV7. 2 interactors.
STRINGi316385.ECDH10B_3366.

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 43Combined sources18
Helixi45 – 50Combined sources6
Helixi54 – 62Combined sources9
Helixi64 – 66Combined sources3
Helixi69 – 77Combined sources9
Helixi79 – 82Combined sources4
Helixi86 – 108Combined sources23
Beta strandi115 – 118Combined sources4
Beta strandi128 – 137Combined sources10
Beta strandi145 – 153Combined sources9
Turni155 – 157Combined sources3
Beta strandi160 – 167Combined sources8
Helixi172 – 179Combined sources8
Helixi181 – 200Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UWAX-ray1.50A/B21-210[»]
ProteinModelPortaliP0ADV7.
SMRiP0ADV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MlaC/ttg2D family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E3I. Bacteria.
COG2854. LUCA.
HOGENOMiHOG000284031.
InParanoidiP0ADV7.
KOiK07323.
PhylomeDBiP0ADV7.

Family and domain databases

InterProiView protein in InterPro
IPR008869. MlaC/ttg2D.
PfamiView protein in Pfam
PF05494. MlaC. 1 hit.
PIRSFiPIRSF004649. MlaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ADV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRLMMVAL LVIAPLSAAT AADQTNPYKL MDEAAQKTFD RLKNEQPQIR
60 70 80 90 100
ANPDYLRTIV DQELLPYVQV KYAGALVLGQ YYKSATPAQR EAYFAAFREY
110 120 130 140 150
LKQAYGQALA MYHGQTYQIA PEQPLGDKTI VPIRVTIIDP NGRPPVRLDF
160 170 180 190 200
QWRKNSQTGN WQAYDMIAEG VSMITTKQNE WGTLLRTKGI DGLTAQLKSI
210
SQQKITLEEK K
Length:211
Mass (Da):23,963
Last modified:December 6, 2005 - v1
Checksum:iA8F22EDFB0830763
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57993.1.
U00096 Genomic DNA. Translation: AAC76224.1.
AP009048 Genomic DNA. Translation: BAE77236.1.
PIRiB65110.
RefSeqiNP_417659.1. NC_000913.3.
WP_000476487.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76224; AAC76224; b3192.
BAE77236; BAE77236; BAE77236.
GeneIDi947710.
KEGGiecj:JW3159.
eco:b3192.
PATRICifig|1411691.4.peg.3539.

Similar proteinsi

Entry informationi

Entry nameiMLAC_ECOLI
AccessioniPrimary (citable) accession number: P0ADV7
Secondary accession number(s): P45390, Q2M920
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: August 30, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families