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Protein

Cell division protein ZapA

Gene

zapA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.1 Publication

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

GO - Biological processi

  • cell division Source: EcoliWiki
  • division septum assembly Source: EcoliWiki
  • FtsZ-dependent cytokinesis Source: EcoCyc
  • septin ring assembly Source: EcoliWiki

Keywordsi

Biological processCell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciEcoCyc:EG12878-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein ZapA
Alternative name(s):
Z ring-associated protein ZapA
Gene namesi
Name:zapA
Synonyms:ygfE
Ordered Locus Names:b2910, JW2878
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12878 zapA

Subcellular locationi

  • Cytoplasm 1 Publication
  • Note: Localizes at mid-cell.

GO - Cellular componenti

  • cell division site Source: EcoliWiki
  • cell septum Source: EcoliWiki
  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001693501 – 109Cell division protein ZapAAdd BLAST109

Proteomic databases

EPDiP0ADS2
PaxDbiP0ADS2
PRIDEiP0ADS2

Interactioni

Subunit structurei

Homodimer. Interacts with FtsZ.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
zapBP0AF364EBI-1119901,EBI-1134093

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4262169, 355 interactors
IntActiP0ADS2, 8 interactors
STRINGi316385.ECDH10B_3084

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 10Combined sources6
Beta strandi13 – 18Combined sources6
Helixi21 – 23Combined sources3
Helixi24 – 45Combined sources22
Helixi50 – 101Combined sources52

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P1MX-ray1.95A/B1-109[»]
ProteinModelPortaliP0ADS2
SMRiP0ADS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 99Sequence analysisAdd BLAST79

Sequence similaritiesi

Belongs to the ZapA family. Type 1 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4107YUN Bacteria
COG3027 LUCA
HOGENOMiHOG000263522
InParanoidiP0ADS2
KOiK09888
OMAiNICYELH
PhylomeDBiP0ADS2

Family and domain databases

HAMAPiMF_02012 ZapA_type1, 1 hit
InterProiView protein in InterPro
IPR007838 Cell_div_ZapA-like
IPR036192 Cell_div_ZapA-like_sf
IPR023771 Cell_div_ZapA_eubact
PfamiView protein in Pfam
PF05164 ZapA, 1 hit
SUPFAMiSSF102829 SSF102829, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQPVDIQI FGRSLRVNCP PDQRDALNQA ADDLNQRLQD LKERTRVTNT
60 70 80 90 100
EQLVFIAALN ISYELAQEKA KTRDYAASME QRIRMLQQTI EQALLEQGRI

TEKTNQNFE
Length:109
Mass (Da):12,594
Last modified:December 6, 2005 - v1
Checksum:i26777CC2B2B71148
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → Y (PubMed:1339425).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69078.1
U00096 Genomic DNA Translation: AAC75948.1
AP009048 Genomic DNA Translation: BAE76975.1
D90281 Genomic DNA No translation available.
M12965 Genomic DNA No translation available.
PIRiF65075
RefSeqiNP_417386.1, NC_000913.3
WP_001276008.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75948; AAC75948; b2910
BAE76975; BAE76975; BAE76975
GeneIDi947404
KEGGiecj:JW2878
eco:b2910
PATRICifig|1411691.4.peg.3822

Similar proteinsi

Entry informationi

Entry nameiZAPA_ECOLI
AccessioniPrimary (citable) accession number: P0ADS2
Secondary accession number(s): P45580, Q2M9T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health