P0ADI7 (YECD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isochorismatase family protein YecD
EC=3.-.-.-

Gene names

Name:	yecD
Ordered Locus Names:	b1867, JW5307

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the isochorismatase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 188

188

Isochorismatase family protein YecD

PRO_0000201831

Experimental info

Sequence conflict

180 – 188

9

SVEEILNAL → TWKRSSTRYDLHRSTAMVAS Ref.1

Secondary structure

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188

Helix Strand Turn

Details...

Helix

6 – 8

3

Beta strand

9 – 14

6

Turn

18 – 20

3

Helix

21 – 23

3

Beta strand

26 – 28

3

Helix

30 – 46

17

Beta strand

51 – 56

6

Turn

81 – 84

4

Helix

88 – 90

3

Beta strand

96 – 107

12

Helix

112 – 118

7

Beta strand

123 – 129

7

Turn

131 – 133

3

Helix

134 – 144

11

Beta strand

148 – 160

13

Helix

161 – 170

10

Helix

172 – 175

4

Beta strand

176 – 179

4

Helix

181 – 187

7

Sequences

	Sequence		Length	Mass (Da)
	P0ADI7 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 3850DE203370249E	FASTA	188	20,452
	10 20 30 40 50 60 MLELNAKTTA LVVIDLQEGI LPFAGGPHTA DEVVNRAGKL AAKFRASGQP VFLVRVGWSA 70 80 90 100 110 120 DYAEALKQPV DAPSPAKVLP ENWWQHPAAL GATDSDIEII KRQWGAFYGT DLELQLRRRG 130 140 150 160 170 180 IDTIVLCGIS TNIGVESTAR NAWELGFNLV IAEDACSAAS AEQHNNSINH IYPRIARVRS VEEILNAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Aspartyl-tRNA synthetase from Escherichia coli: cloning and characterisation of the gene, homologies of its translated amino acid sequence with asparaginyl- and lysyl-tRNA synthetases." Eriani G., Dirheimer G., Gangloff J. Nucleic Acids Res. 18:7109-7118(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T. DNA Res. 3:379-392(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Intrinsic and extrinsic approaches for detecting genes in a bacterial genome." Borodovsky M., Rudd K.E., Koonin E.V. Nucleic Acids Res. 22:4756-4767(1994) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	"Structural genomics of highly conserved microbial genes of unknown function in search of new antibacterial targets." Abergel C., Coutard B., Byrne D., Chenivesse S., Claude J.-B., Deregnaucourt C., Fricaux T., Gianesini-Boutreux C., Jeudy S., Lebrun R., Maza C., Notredame C., Poirot O., Suhre K., Varagnol M., Claverie J.-M. J. Struct. Funct. Genomics 4:141-157(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X53863 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAC74937.2.
AP009048 Genomic DNA. Translation: BAA15678.1.

PIR

C64949.

RefSeq

NP_416381.2. NC_000913.2.
YP_490129.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1J2R	X-ray	1.30	A/B/C/D	1-188	[»]

ProteinModelPortal

P0ADI7.

SMR

P0ADI7. Positions 1-188.

ModBase

Search...

Protein-protein interaction databases

STRING

511145.b1867.

Proteomic databases

PaxDb

P0ADI7.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC74937; AAC74937; b1867.
BAA15678; BAA15678; BAA15678.

GeneID

12930338.
946384.

KEGG

ecj:Y75_p1843.
eco:b1867.

PATRIC

32119057. VBIEscCol129921_1946.

Organism-specific databases

EchoBASE

EB2280.

EcoGene

EG12378. yecD.

Phylogenomic databases

eggNOG

COG1335.

HOGENOM

HOG000078668.

OMA

WELGFSL.

ProtClustDB

PRK11440.

Enzyme and pathway databases

BioCyc

EcoCyc:EG12378-MONOMER.
ECOL316407:JW5307-MONOMER.

Gene expression databases

Genevestigator

P0ADI7.

Family and domain databases

Gene3D

3.40.50.850. 1 hit.

InterPro

IPR000868. Isochorismatase-like.
[Graphical view]

Pfam

PF00857. Isochorismatase. 1 hit.
[Graphical view]

SUPFAM

SSF52499. Iscrsm_hydrolase. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P0ADI7.

Entry information

Entry name

YECD_ECOLI

Accession

Primary (citable) accession number: P0ADI7
Secondary accession number(s): P37347, P76287

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program