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Protein

Type 1 fimbriae regulatory protein FimE

Gene

fimE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei171 – 1711O-(3'-phospho-DNA)-tyrosine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

  • DNA integration Source: EcoCyc
  • DNA recombination Source: EcoCyc
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA integration, DNA recombination, Fimbrium biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG10312-MONOMER.
ECOL316407:JW4276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 1 fimbriae regulatory protein FimE
Gene namesi
Name:fimE
Ordered Locus Names:b4313, JW4276
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10312. fimE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Type 1 fimbriae regulatory protein FimEPRO_0000197541Add
BLAST

Proteomic databases

PaxDbiP0ADH7.

Interactioni

Protein-protein interaction databases

BioGridi4259379. 56 interactions.
IntActiP0ADH7. 1 interaction.
STRINGi511145.b4313.

Structurei

3D structure databases

ProteinModelPortaliP0ADH7.
SMRiP0ADH7. Positions 36-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG4105E71. Bacteria.
COG0582. LUCA.
HOGENOMiHOG000117333.
InParanoidiP0ADH7.
KOiK07358.
OMAiKRDYLFF.
PhylomeDBiP0ADH7.

Family and domain databases

Gene3Di1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
[Graphical view]
PfamiPF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ADH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRRYLTGK EVQAMMQAVC YGATGARDYC LILLAYRHGM RISELLDLHY
60 70 80 90 100
QDLDLNEGRI NIRRLKNGFS TVHPLRFDER EAVERWTQER ANWKGADRTD
110 120 130 140 150
AIFISRRGSR LSRQQAYRII RDAGIEAGTV TQTHPHMLRH ACGYELAERG
160 170 180 190
ADTRLIQDYL GHRNIRHTVR YTASNAARFA GLWERNNLIN EKLKREEV
Length:198
Mass (Da):23,116
Last modified:August 13, 1987 - v1
Checksum:iA33139B0378CB37D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03923 Genomic DNA. Translation: CAA27561.1.
U14003 Genomic DNA. Translation: AAA97209.1.
U00096 Genomic DNA. Translation: AAC77269.1.
AP009048 Genomic DNA. Translation: BAE78306.1.
PIRiB25111. RGECFE.
RefSeqiNP_418733.1. NC_000913.3.
WP_000044711.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77269; AAC77269; b4313.
BAE78306; BAE78306; BAE78306.
GeneIDi948836.
KEGGiecj:JW4276.
eco:b4313.
PATRICi32124222. VBIEscCol129921_4454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03923 Genomic DNA. Translation: CAA27561.1.
U14003 Genomic DNA. Translation: AAA97209.1.
U00096 Genomic DNA. Translation: AAC77269.1.
AP009048 Genomic DNA. Translation: BAE78306.1.
PIRiB25111. RGECFE.
RefSeqiNP_418733.1. NC_000913.3.
WP_000044711.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ADH7.
SMRiP0ADH7. Positions 36-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259379. 56 interactions.
IntActiP0ADH7. 1 interaction.
STRINGi511145.b4313.

Proteomic databases

PaxDbiP0ADH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77269; AAC77269; b4313.
BAE78306; BAE78306; BAE78306.
GeneIDi948836.
KEGGiecj:JW4276.
eco:b4313.
PATRICi32124222. VBIEscCol129921_4454.

Organism-specific databases

EchoBASEiEB0308.
EcoGeneiEG10312. fimE.

Phylogenomic databases

eggNOGiENOG4105E71. Bacteria.
COG0582. LUCA.
HOGENOMiHOG000117333.
InParanoidiP0ADH7.
KOiK07358.
OMAiKRDYLFF.
PhylomeDBiP0ADH7.

Enzyme and pathway databases

BioCyciEcoCyc:EG10312-MONOMER.
ECOL316407:JW4276-MONOMER.

Miscellaneous databases

PROiP0ADH7.

Family and domain databases

Gene3Di1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
[Graphical view]
PfamiPF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFIME_ECOLI
AccessioniPrimary (citable) accession number: P0ADH7
Secondary accession number(s): P04741, Q2M600
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.