Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Type 1 fimbriae regulatory protein FimB

Gene

fimB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches fimA on (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176O-(3'-phospho-DNA)-tyrosine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA integration, DNA recombination, Fimbrium biogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Type 1 fimbriae regulatory protein FimB
Gene namesi
Name:fimB
Ordered Locus Names:Z5910, ECs5271
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975401 – 200Type 1 fimbriae regulatory protein FimBAdd BLAST200

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5910

Structurei

3D structure databases

ProteinModelPortaliP0ADH6
SMRiP0ADH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG4108W9T Bacteria
ENOG410YF4U LUCA
HOGENOMiHOG000117333
KOiK07357
OMAiKRWLAIR

Family and domain databases

Gene3Di1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
PfamiView protein in Pfam
PF00589 Phage_integrase, 1 hit
SUPFAMiSSF56349 SSF56349, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKADNKKR NFLTHSEIES LLKAANTGPH AARNYCLTLL CFIHGFRASE
60 70 80 90 100
ICRLRISDID LKAKCIYIHR LKKGFSTTHP LLNKEVQALK NWLSIRTSYP
110 120 130 140 150
HAESEWVFLS RKGNPLSRQQ FYHIISTSGG NAGLSLEIHP HMLRHSCGFA
160 170 180 190 200
LANMGIDTRL IQDYLGHRNI RHTVWYTASN AGRFYGIWDR ARGRQRHAVL
Length:200
Mass (Da):22,993
Last modified:December 6, 2005 - v1
Checksum:i36BFC656C68837C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59494.1
BA000007 Genomic DNA Translation: BAB38694.1
PIRiB86129
G91287
RefSeqiNP_313298.1, NC_002695.1
WP_000790583.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG59494; AAG59494; Z5910
BAB38694; BAB38694; BAB38694
GeneIDi913695
KEGGiece:Z5910
ecs:ECs5271
PATRICifig|386585.9.peg.5507

Similar proteinsi

Entry informationi

Entry nameiFIMB_ECO57
AccessioniPrimary (citable) accession number: P0ADH6
Secondary accession number(s): P04742, Q47219
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 6, 2005
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health