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Protein

Type 1 fimbriae regulatory protein FimB

Gene

fimB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches fimA on (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176O-(3'-phospho-DNA)-tyrosine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA integration, DNA recombination, Fimbrium biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciECOO157:FIMB-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 1 fimbriae regulatory protein FimB
Gene namesi
Name:fimB
Ordered Locus Names:Z5910, ECs5271
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975401 – 200Type 1 fimbriae regulatory protein FimBAdd BLAST200

Interactioni

Protein-protein interaction databases

MINTiMINT-1221125.
STRINGi155864.Z5910.

Structurei

3D structure databases

ProteinModelPortaliP0ADH6.
SMRiP0ADH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG4108W9T. Bacteria.
ENOG410YF4U. LUCA.
HOGENOMiHOG000117333.
KOiK07357.
OMAiNFLTQNE.

Family and domain databases

Gene3Di1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
[Graphical view]
PfamiPF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ADH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKADNKKR NFLTHSEIES LLKAANTGPH AARNYCLTLL CFIHGFRASE
60 70 80 90 100
ICRLRISDID LKAKCIYIHR LKKGFSTTHP LLNKEVQALK NWLSIRTSYP
110 120 130 140 150
HAESEWVFLS RKGNPLSRQQ FYHIISTSGG NAGLSLEIHP HMLRHSCGFA
160 170 180 190 200
LANMGIDTRL IQDYLGHRNI RHTVWYTASN AGRFYGIWDR ARGRQRHAVL
Length:200
Mass (Da):22,993
Last modified:December 6, 2005 - v1
Checksum:i36BFC656C68837C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59494.1.
BA000007 Genomic DNA. Translation: BAB38694.1.
PIRiB86129.
G91287.
RefSeqiNP_313298.1. NC_002695.1.
WP_000790583.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG59494; AAG59494; Z5910.
BAB38694; BAB38694; BAB38694.
GeneIDi913695.
KEGGiece:Z5910.
ecs:ECs5271.
PATRICi18360181. VBIEscCol44059_5222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59494.1.
BA000007 Genomic DNA. Translation: BAB38694.1.
PIRiB86129.
G91287.
RefSeqiNP_313298.1. NC_002695.1.
WP_000790583.1. NZ_LPWC02000002.1.

3D structure databases

ProteinModelPortaliP0ADH6.
SMRiP0ADH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1221125.
STRINGi155864.Z5910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG59494; AAG59494; Z5910.
BAB38694; BAB38694; BAB38694.
GeneIDi913695.
KEGGiece:Z5910.
ecs:ECs5271.
PATRICi18360181. VBIEscCol44059_5222.

Phylogenomic databases

eggNOGiENOG4108W9T. Bacteria.
ENOG410YF4U. LUCA.
HOGENOMiHOG000117333.
KOiK07357.
OMAiNFLTQNE.

Enzyme and pathway databases

BioCyciECOO157:FIMB-MONOMER.

Family and domain databases

Gene3Di1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
[Graphical view]
PfamiPF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFIMB_ECO57
AccessioniPrimary (citable) accession number: P0ADH6
Secondary accession number(s): P04742, Q47219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.