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Protein

Inositol-1-monophosphatase

Gene

suhB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Magnesium 1By similarity1
Binding sitei67SubstrateBy similarity1
Metal bindingi84Magnesium 1By similarity1
Metal bindingi84Magnesium 2By similarity1
Metal bindingi86Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi87Magnesium 2By similarity1
Binding sitei183SubstrateBy similarity1
Metal bindingi212Magnesium 2By similarity1
Binding sitei212SubstrateBy similarity1

GO - Molecular functioni

  • glycerol-2-phosphatase activity Source: EcoCyc
  • inositol monophosphate 1-phosphatase activity Source: EcoliWiki
  • inositol monophosphate 3-phosphatase activity Source: UniProtKB-EC
  • inositol monophosphate 4-phosphatase activity Source: UniProtKB-EC
  • lithium ion binding Source: EcoliWiki
  • magnesium ion binding Source: EcoliWiki

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10983-MONOMER
MetaCyc:EG10983-MONOMER
BRENDAi3.1.3.25 2026
SABIO-RKiP0ADG4

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-1-monophosphatase (EC:3.1.3.25)
Short name:
I-1-Pase
Short name:
IMPase
Short name:
Inositol-1-phosphatase
Gene namesi
Name:suhB
Synonyms:ssyA
Ordered Locus Names:b2533, JW2517
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10983 suhB

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425591 – 267Inositol-1-monophosphataseAdd BLAST267

Proteomic databases

EPDiP0ADG4
PaxDbiP0ADG4
PRIDEiP0ADG4

2D gel databases

SWISS-2DPAGEiP0ADG4

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi4260600, 8 interactors
IntActiP0ADG4, 10 interactors
STRINGi316385.ECDH10B_2700

Structurei

Secondary structure

1267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 23Combined sources22
Beta strandi33 – 35Combined sources3
Helixi38 – 58Combined sources21
Beta strandi62 – 66Combined sources5
Turni67 – 69Combined sources3
Beta strandi70 – 72Combined sources3
Beta strandi75 – 87Combined sources13
Helixi89 – 94Combined sources6
Beta strandi100 – 107Combined sources8
Beta strandi110 – 118Combined sources9
Turni119 – 122Combined sources4
Beta strandi123 – 128Combined sources6
Beta strandi133 – 135Combined sources3
Beta strandi151 – 155Combined sources5
Helixi162 – 164Combined sources3
Helixi165 – 176Combined sources12
Turni177 – 179Combined sources3
Beta strandi180 – 184Combined sources5
Helixi188 – 196Combined sources9
Beta strandi199 – 207Combined sources9
Helixi210 – 222Combined sources13
Beta strandi226 – 228Combined sources3
Beta strandi232 – 234Combined sources3
Helixi236 – 239Combined sources4
Beta strandi242 – 245Combined sources4
Helixi247 – 255Combined sources9
Turni256 – 259Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QFLX-ray1.90A1-267[»]
ProteinModelPortaliP0ADG4
SMRiP0ADG4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ADG4

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 89Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105ECY Bacteria
COG0483 LUCA
HOGENOMiHOG000282238
InParanoidiP0ADG4
KOiK01092
OMAiNNYAEFC
PhylomeDBiP0ADG4

Family and domain databases

CDDicd01639 IMPase, 1 hit
InterProiView protein in InterPro
IPR033942 IMPase
IPR020583 Inositol_monoP_metal-BS
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
IPR022337 Inositol_monophosphatase_SuhB
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PRINTSiPR00377 IMPHPHTASES
PR01959 SBIMPHPHTASE
PROSITEiView protein in PROSITE
PS00629 IMP_1, 1 hit
PS00630 IMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPMLNIAVR AARKAGNLIA KNYETPDAVE ASQKGSNDFV TNVDKAAEAV
60 70 80 90 100
IIDTIRKSYP QHTIITEESG ELEGTDQDVQ WVIDPLDGTT NFIKRLPHFA
110 120 130 140 150
VSIAVRIKGR TEVAVVYDPM RNELFTATRG QGAQLNGYRL RGSTARDLDG
160 170 180 190 200
TILATGFPFK AKQYATTYIN IVGKLFNECA DFRRTGSAAL DLAYVAAGRV
210 220 230 240 250
DGFFEIGLRP WDFAAGELLV REAGGIVSDF TGGHNYMLTG NIVAGNPRVV
260
KAMLANMRDE LSDALKR
Length:267
Mass (Da):29,172
Last modified:December 6, 2005 - v1
Checksum:i8FEC3508BD111301
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141R → L in AAA67506 (PubMed:2138605).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34828 Genomic DNA Translation: AAA67506.1
U00096 Genomic DNA Translation: AAC75586.1
AP009048 Genomic DNA Translation: BAA16427.1
PIRiD65030
RefSeqiNP_417028.1, NC_000913.3
WP_000553451.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75586; AAC75586; b2533
BAA16427; BAA16427; BAA16427
GeneIDi947285
KEGGiecj:JW2517
eco:b2533
PATRICifig|1411691.4.peg.4201

Similar proteinsi

Entry informationi

Entry nameiSUHB_ECOLI
AccessioniPrimary (citable) accession number: P0ADG4
Secondary accession number(s): P22783, P77511, Q8X2E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health