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Protein

Inositol-1-monophosphatase

Gene

suhB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Magnesium 1By similarity1
Binding sitei67SubstrateBy similarity1
Metal bindingi84Magnesium 1By similarity1
Metal bindingi84Magnesium 2By similarity1
Metal bindingi86Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi87Magnesium 2By similarity1
Binding sitei183SubstrateBy similarity1
Metal bindingi212Magnesium 2By similarity1
Binding sitei212SubstrateBy similarity1

GO - Molecular functioni

  • glycerol-2-phosphatase activity Source: EcoCyc
  • inositol monophosphate 1-phosphatase activity Source: EcoliWiki
  • inositol monophosphate 3-phosphatase activity Source: UniProtKB-EC
  • inositol monophosphate 4-phosphatase activity Source: UniProtKB-EC
  • lithium ion binding Source: EcoliWiki
  • magnesium ion binding Source: EcoliWiki

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10983-MONOMER.
ECOL316407:JW2517-MONOMER.
MetaCyc:EG10983-MONOMER.
BRENDAi3.1.3.25. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-1-monophosphatase (EC:3.1.3.25)
Short name:
I-1-Pase
Short name:
IMPase
Short name:
Inositol-1-phosphatase
Gene namesi
Name:suhB
Synonyms:ssyA
Ordered Locus Names:b2533, JW2517
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10983. suhB.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425591 – 267Inositol-1-monophosphataseAdd BLAST267

Proteomic databases

EPDiP0ADG4.
PaxDbiP0ADG4.
PRIDEiP0ADG4.

2D gel databases

SWISS-2DPAGEP0ADG4.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP0ADG4. 10 interactors.
STRINGi511145.b2533.

Structurei

Secondary structure

1267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 23Combined sources22
Beta strandi33 – 35Combined sources3
Helixi38 – 58Combined sources21
Beta strandi62 – 66Combined sources5
Turni67 – 69Combined sources3
Beta strandi70 – 72Combined sources3
Beta strandi75 – 87Combined sources13
Helixi89 – 94Combined sources6
Beta strandi100 – 107Combined sources8
Beta strandi110 – 118Combined sources9
Turni119 – 122Combined sources4
Beta strandi123 – 128Combined sources6
Beta strandi133 – 135Combined sources3
Beta strandi151 – 155Combined sources5
Helixi162 – 164Combined sources3
Helixi165 – 176Combined sources12
Turni177 – 179Combined sources3
Beta strandi180 – 184Combined sources5
Helixi188 – 196Combined sources9
Beta strandi199 – 207Combined sources9
Helixi210 – 222Combined sources13
Beta strandi226 – 228Combined sources3
Beta strandi232 – 234Combined sources3
Helixi236 – 239Combined sources4
Beta strandi242 – 245Combined sources4
Helixi247 – 255Combined sources9
Turni256 – 259Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QFLX-ray1.90A1-267[»]
ProteinModelPortaliP0ADG4.
SMRiP0ADG4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ADG4.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 89Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiENOG4105ECY. Bacteria.
COG0483. LUCA.
HOGENOMiHOG000282238.
InParanoidiP0ADG4.
KOiK01092.
OMAiIGIFEDG.
PhylomeDBiP0ADG4.

Family and domain databases

CDDicd01639. IMPase. 1 hit.
InterProiIPR033942. IMPase.
IPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
IPR022337. Inositol_monophosphatase_SuhB.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR01959. SBIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ADG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPMLNIAVR AARKAGNLIA KNYETPDAVE ASQKGSNDFV TNVDKAAEAV
60 70 80 90 100
IIDTIRKSYP QHTIITEESG ELEGTDQDVQ WVIDPLDGTT NFIKRLPHFA
110 120 130 140 150
VSIAVRIKGR TEVAVVYDPM RNELFTATRG QGAQLNGYRL RGSTARDLDG
160 170 180 190 200
TILATGFPFK AKQYATTYIN IVGKLFNECA DFRRTGSAAL DLAYVAAGRV
210 220 230 240 250
DGFFEIGLRP WDFAAGELLV REAGGIVSDF TGGHNYMLTG NIVAGNPRVV
260
KAMLANMRDE LSDALKR
Length:267
Mass (Da):29,172
Last modified:December 6, 2005 - v1
Checksum:i8FEC3508BD111301
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141R → L in AAA67506 (PubMed:2138605).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34828 Genomic DNA. Translation: AAA67506.1.
U00096 Genomic DNA. Translation: AAC75586.1.
AP009048 Genomic DNA. Translation: BAA16427.1.
PIRiD65030.
RefSeqiNP_417028.1. NC_000913.3.
WP_000553451.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75586; AAC75586; b2533.
BAA16427; BAA16427; BAA16427.
GeneIDi947285.
KEGGiecj:JW2517.
eco:b2533.
PATRICi32120463. VBIEscCol129921_2634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34828 Genomic DNA. Translation: AAA67506.1.
U00096 Genomic DNA. Translation: AAC75586.1.
AP009048 Genomic DNA. Translation: BAA16427.1.
PIRiD65030.
RefSeqiNP_417028.1. NC_000913.3.
WP_000553451.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QFLX-ray1.90A1-267[»]
ProteinModelPortaliP0ADG4.
SMRiP0ADG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0ADG4. 10 interactors.
STRINGi511145.b2533.

2D gel databases

SWISS-2DPAGEP0ADG4.

Proteomic databases

EPDiP0ADG4.
PaxDbiP0ADG4.
PRIDEiP0ADG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75586; AAC75586; b2533.
BAA16427; BAA16427; BAA16427.
GeneIDi947285.
KEGGiecj:JW2517.
eco:b2533.
PATRICi32120463. VBIEscCol129921_2634.

Organism-specific databases

EchoBASEiEB0976.
EcoGeneiEG10983. suhB.

Phylogenomic databases

eggNOGiENOG4105ECY. Bacteria.
COG0483. LUCA.
HOGENOMiHOG000282238.
InParanoidiP0ADG4.
KOiK01092.
OMAiIGIFEDG.
PhylomeDBiP0ADG4.

Enzyme and pathway databases

BioCyciEcoCyc:EG10983-MONOMER.
ECOL316407:JW2517-MONOMER.
MetaCyc:EG10983-MONOMER.
BRENDAi3.1.3.25. 2026.

Miscellaneous databases

EvolutionaryTraceiP0ADG4.
PROiP0ADG4.

Family and domain databases

CDDicd01639. IMPase. 1 hit.
InterProiIPR033942. IMPase.
IPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
IPR022337. Inositol_monophosphatase_SuhB.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR01959. SBIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUHB_ECOLI
AccessioniPrimary (citable) accession number: P0ADG4
Secondary accession number(s): P22783, P77511, Q8X2E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.