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Protein

Inositol-1-monophosphatase

Gene

suhB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Magnesium 1By similarity
Binding sitei67 – 671SubstrateBy similarity
Metal bindingi84 – 841Magnesium 1By similarity
Metal bindingi84 – 841Magnesium 2By similarity
Metal bindingi86 – 861Magnesium 1; via carbonyl oxygenBy similarity
Metal bindingi87 – 871Magnesium 2By similarity
Binding sitei183 – 1831SubstrateBy similarity
Metal bindingi212 – 2121Magnesium 2By similarity
Binding sitei212 – 2121SubstrateBy similarity

GO - Molecular functioni

  • glycerol-2-phosphatase activity Source: EcoCyc
  • inositol monophosphate 1-phosphatase activity Source: EcoliWiki
  • inositol monophosphate 3-phosphatase activity Source: UniProtKB-EC
  • inositol monophosphate 4-phosphatase activity Source: UniProtKB-EC
  • lithium ion binding Source: EcoliWiki
  • magnesium ion binding Source: EcoliWiki

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10983-MONOMER.
ECOL316407:JW2517-MONOMER.
MetaCyc:EG10983-MONOMER.
BRENDAi3.1.3.25. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-1-monophosphatase (EC:3.1.3.25)
Short name:
I-1-Pase
Short name:
IMPase
Short name:
Inositol-1-phosphatase
Gene namesi
Name:suhB
Synonyms:ssyA
Ordered Locus Names:b2533, JW2517
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10983. suhB.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Inositol-1-monophosphatasePRO_0000142559Add
BLAST

Proteomic databases

EPDiP0ADG4.
PaxDbiP0ADG4.
PRIDEiP0ADG4.

2D gel databases

SWISS-2DPAGEP0ADG4.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP0ADG4. 10 interactions.
STRINGi511145.b2533.

Structurei

Secondary structure

1
267
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 2322Combined sources
Beta strandi33 – 353Combined sources
Helixi38 – 5821Combined sources
Beta strandi62 – 665Combined sources
Turni67 – 693Combined sources
Beta strandi70 – 723Combined sources
Beta strandi75 – 8713Combined sources
Helixi89 – 946Combined sources
Beta strandi100 – 1078Combined sources
Beta strandi110 – 1189Combined sources
Turni119 – 1224Combined sources
Beta strandi123 – 1286Combined sources
Beta strandi133 – 1353Combined sources
Beta strandi151 – 1555Combined sources
Helixi162 – 1643Combined sources
Helixi165 – 17612Combined sources
Turni177 – 1793Combined sources
Beta strandi180 – 1845Combined sources
Helixi188 – 1969Combined sources
Beta strandi199 – 2079Combined sources
Helixi210 – 22213Combined sources
Beta strandi226 – 2283Combined sources
Beta strandi232 – 2343Combined sources
Helixi236 – 2394Combined sources
Beta strandi242 – 2454Combined sources
Helixi247 – 2559Combined sources
Turni256 – 2594Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QFLX-ray1.90A1-267[»]
ProteinModelPortaliP0ADG4.
SMRiP0ADG4. Positions 1-262.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ADG4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 894Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiENOG4105ECY. Bacteria.
COG0483. LUCA.
HOGENOMiHOG000282238.
InParanoidiP0ADG4.
KOiK01092.
OMAiIGIFEDG.
PhylomeDBiP0ADG4.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
IPR022337. Inositol_monophosphatase_SuhB.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR01959. SBIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ADG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPMLNIAVR AARKAGNLIA KNYETPDAVE ASQKGSNDFV TNVDKAAEAV
60 70 80 90 100
IIDTIRKSYP QHTIITEESG ELEGTDQDVQ WVIDPLDGTT NFIKRLPHFA
110 120 130 140 150
VSIAVRIKGR TEVAVVYDPM RNELFTATRG QGAQLNGYRL RGSTARDLDG
160 170 180 190 200
TILATGFPFK AKQYATTYIN IVGKLFNECA DFRRTGSAAL DLAYVAAGRV
210 220 230 240 250
DGFFEIGLRP WDFAAGELLV REAGGIVSDF TGGHNYMLTG NIVAGNPRVV
260
KAMLANMRDE LSDALKR
Length:267
Mass (Da):29,172
Last modified:December 6, 2005 - v1
Checksum:i8FEC3508BD111301
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411R → L in AAA67506 (PubMed:2138605).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34828 Genomic DNA. Translation: AAA67506.1.
U00096 Genomic DNA. Translation: AAC75586.1.
AP009048 Genomic DNA. Translation: BAA16427.1.
PIRiD65030.
RefSeqiNP_417028.1. NC_000913.3.
WP_000553451.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75586; AAC75586; b2533.
BAA16427; BAA16427; BAA16427.
GeneIDi947285.
KEGGiecj:JW2517.
eco:b2533.
PATRICi32120463. VBIEscCol129921_2634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34828 Genomic DNA. Translation: AAA67506.1.
U00096 Genomic DNA. Translation: AAC75586.1.
AP009048 Genomic DNA. Translation: BAA16427.1.
PIRiD65030.
RefSeqiNP_417028.1. NC_000913.3.
WP_000553451.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QFLX-ray1.90A1-267[»]
ProteinModelPortaliP0ADG4.
SMRiP0ADG4. Positions 1-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0ADG4. 10 interactions.
STRINGi511145.b2533.

2D gel databases

SWISS-2DPAGEP0ADG4.

Proteomic databases

EPDiP0ADG4.
PaxDbiP0ADG4.
PRIDEiP0ADG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75586; AAC75586; b2533.
BAA16427; BAA16427; BAA16427.
GeneIDi947285.
KEGGiecj:JW2517.
eco:b2533.
PATRICi32120463. VBIEscCol129921_2634.

Organism-specific databases

EchoBASEiEB0976.
EcoGeneiEG10983. suhB.

Phylogenomic databases

eggNOGiENOG4105ECY. Bacteria.
COG0483. LUCA.
HOGENOMiHOG000282238.
InParanoidiP0ADG4.
KOiK01092.
OMAiIGIFEDG.
PhylomeDBiP0ADG4.

Enzyme and pathway databases

BioCyciEcoCyc:EG10983-MONOMER.
ECOL316407:JW2517-MONOMER.
MetaCyc:EG10983-MONOMER.
BRENDAi3.1.3.25. 2026.

Miscellaneous databases

EvolutionaryTraceiP0ADG4.
PROiP0ADG4.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
IPR022337. Inositol_monophosphatase_SuhB.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR01959. SBIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUHB_ECOLI
AccessioniPrimary (citable) accession number: P0ADG4
Secondary accession number(s): P22783, P77511, Q8X2E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.