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Protein

Phosphogluconate dehydratase

Gene

edd

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O.

Pathwayi: Entner-Doudoroff pathway

This protein is involved in the pathway Entner-Doudoroff pathway, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway Entner-Doudoroff pathway and in Carbohydrate metabolism.

GO - Molecular functioni

  • phosphogluconate dehydratase activity Source: EcoliWiki

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciEcoCyc:PGLUCONDEHYDRAT-MONOMER.
ECOL316407:JW1840-MONOMER.
MetaCyc:PGLUCONDEHYDRAT-MONOMER.
UniPathwayiUPA00226.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphogluconate dehydratase (EC:4.2.1.12)
Alternative name(s):
6-phosphogluconate dehydratase
Gene namesi
Name:edd
Ordered Locus Names:b1851, JW1840
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10257. edd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001035531 – 603Phosphogluconate dehydrataseAdd BLAST603

Proteomic databases

PaxDbiP0ADF6.
PRIDEiP0ADF6.

Expressioni

Inductioni

By growth on gluconate.

Interactioni

Protein-protein interaction databases

BioGridi4261382. 5 interactors.
DIPiDIP-47906N.
IntActiP0ADF6. 8 interactors.
STRINGi511145.b1851.

Structurei

3D structure databases

ProteinModelPortaliP0ADF6.
SMRiP0ADF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.Curated

Phylogenomic databases

eggNOGiENOG4105C01. Bacteria.
COG0129. LUCA.
HOGENOMiHOG000173157.
InParanoidiP0ADF6.
KOiK01690.
OMAiCQHEVEA.
PhylomeDBiP0ADF6.

Family and domain databases

InterProiIPR004786. 6-phosphgluc_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERiPTHR21000. PTHR21000. 1 hit.
PfamiPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR01196. edd. 1 hit.
PROSITEiPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ADF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPQLLRVTN RIIERSRETR SAYLARIEQA KTSTVHRSQL ACGNLAHGFA
60 70 80 90 100
ACQPEDKASL KSMLRNNIAI ITSYNDMLSA HQPYEHYPEI IRKALHEANA
110 120 130 140 150
VGQVAGGVPA MCDGVTQGQD GMELSLLSRE VIAMSAAVGL SHNMFDGALF
160 170 180 190 200
LGVCDKIVPG LTMAALSFGH LPAVFVPSGP MASGLPNKEK VRIRQLYAEG
210 220 230 240 250
KVDRMALLES EAASYHAPGT CTFYGTANTN QMVVEFMGMQ LPGSSFVHPD
260 270 280 290 300
SPLRDALTAA AARQVTRMTG NGNEWMPIGK MIDEKVVVNG IVALLATGGS
310 320 330 340 350
TNHTMHLVAM ARAAGIQINW DDFSDLSDVV PLMARLYPNG PADINHFQAA
360 370 380 390 400
GGVPVLVREL LKAGLLHEDV NTVAGFGLSR YTLEPWLNNG ELDWREGAEK
410 420 430 440 450
SLDSNVIASF EQPFSHHGGT KVLSGNLGRA VMKTSAVPVE NQVIEAPAVV
460 470 480 490 500
FESQHDVMPA FEAGLLDRDC VVVVRHQGPK ANGMPELHKL MPPLGVLLDR
510 520 530 540 550
CFKIALVTDG RLSGASGKVP SAIHVTPEAY DGGLLAKVRD GDIIRVNGQT
560 570 580 590 600
GELTLLVDEA ELAAREPHIP DLSASRVGTG RELFSALREK LSGAEQGATC

ITF
Length:603
Mass (Da):64,639
Last modified:December 6, 2005 - v1
Checksum:iD046405193BFC185
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252 – 254PLR → AC in AAA23722 (PubMed:1624451).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87458 Genomic DNA. Translation: AAA23722.1.
X63694 Genomic DNA. Translation: CAA45221.1.
U00096 Genomic DNA. Translation: AAC74921.1.
AP009048 Genomic DNA. Translation: BAA15659.1.
L20897 Genomic DNA. Translation: AAA23863.1.
PIRiA42986.
RefSeqiNP_416365.1. NC_000913.3.
WP_001069467.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74921; AAC74921; b1851.
BAA15659; BAA15659; BAA15659.
GeneIDi946362.
KEGGiecj:JW1840.
eco:b1851.
PATRICi32119023. VBIEscCol129921_1929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87458 Genomic DNA. Translation: AAA23722.1.
X63694 Genomic DNA. Translation: CAA45221.1.
U00096 Genomic DNA. Translation: AAC74921.1.
AP009048 Genomic DNA. Translation: BAA15659.1.
L20897 Genomic DNA. Translation: AAA23863.1.
PIRiA42986.
RefSeqiNP_416365.1. NC_000913.3.
WP_001069467.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ADF6.
SMRiP0ADF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261382. 5 interactors.
DIPiDIP-47906N.
IntActiP0ADF6. 8 interactors.
STRINGi511145.b1851.

Proteomic databases

PaxDbiP0ADF6.
PRIDEiP0ADF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74921; AAC74921; b1851.
BAA15659; BAA15659; BAA15659.
GeneIDi946362.
KEGGiecj:JW1840.
eco:b1851.
PATRICi32119023. VBIEscCol129921_1929.

Organism-specific databases

EchoBASEiEB0253.
EcoGeneiEG10257. edd.

Phylogenomic databases

eggNOGiENOG4105C01. Bacteria.
COG0129. LUCA.
HOGENOMiHOG000173157.
InParanoidiP0ADF6.
KOiK01690.
OMAiCQHEVEA.
PhylomeDBiP0ADF6.

Enzyme and pathway databases

UniPathwayiUPA00226.
BioCyciEcoCyc:PGLUCONDEHYDRAT-MONOMER.
ECOL316407:JW1840-MONOMER.
MetaCyc:PGLUCONDEHYDRAT-MONOMER.

Miscellaneous databases

PROiP0ADF6.

Family and domain databases

InterProiIPR004786. 6-phosphgluc_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERiPTHR21000. PTHR21000. 1 hit.
PfamiPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR01196. edd. 1 hit.
PROSITEiPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDD_ECOLI
AccessioniPrimary (citable) accession number: P0ADF6
Secondary accession number(s): P25530
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.