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Protein

Lipopolysaccharide export system permease protein LptG

Gene

lptG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.1 Publication

GO - Biological processi

  • lipopolysaccharide transport Source: EcoCyc
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7889-MONOMER.
ECOL316407:JW5760-MONOMER.
MetaCyc:G7889-MONOMER.

Protein family/group databases

TCDBi1.B.42.1.2. the outer membrane lipopolysaccharide export porin (lps-ep) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide export system permease protein LptG
Gene namesi
Name:lptG
Synonyms:yjgQ
Ordered Locus Names:b4262, JW5760
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12536. lptG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 63PeriplasmicSequence analysisAdd BLAST28
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 103CytoplasmicSequence analysisAdd BLAST19
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 278PeriplasmicSequence analysisAdd BLAST154
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 314CytoplasmicSequence analysisAdd BLAST15
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Topological domaini336PeriplasmicSequence analysis1
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 360CytoplasmicSequence analysis3

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001697761 – 360Lipopolysaccharide export system permease protein LptGAdd BLAST360

Proteomic databases

PaxDbiP0ADC6.
PRIDEiP0ADC6.

Interactioni

Subunit structurei

Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).1 Publication

Protein-protein interaction databases

BioGridi4262728. 224 interactors.
IntActiP0ADC6. 1 interactor.
MINTiMINT-7137015.
STRINGi511145.b4262.

Structurei

3D structure databases

ProteinModelPortaliP0ADC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LptF/LptG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108K5H. Bacteria.
COG0795. LUCA.
HOGENOMiHOG000263593.
InParanoidiP0ADC6.
KOiK11720.
OMAiFAYLHAR.
PhylomeDBiP0ADC6.

Family and domain databases

InterProiIPR030923. LptG.
IPR005495. LptG/LptF_permease.
[Graphical view]
PfamiPF03739. YjgP_YjgQ. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04408. LptG_lptG. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ADC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPFGVLDRY IGKTIFTTIM MTLFMLVSLS GIIKFVDQLK KAGQGSYDAL
60 70 80 90 100
GAGMYTLLSV PKDVQIFFPM AALLGALLGL GMLAQRSELV VMQASGFTRM
110 120 130 140 150
QVALSVMKTA IPLVLLTMAI GEWVAPQGEQ MARNYRAQAM YGGSLLSTQQ
160 170 180 190 200
GLWAKDGNNF VYIERVKGDE ELGGISIYAF NENRRLQSVR YAATAKFDPE
210 220 230 240 250
HKVWRLSQVD ESDLTNPKQI TGSQTVSGTW KTNLTPDKLG VVALDPDALS
260 270 280 290 300
ISGLHNYVKY LKSSGQDAGR YQLNMWSKIF QPLSVAVMML MALSFIFGPL
310 320 330 340 350
RSVPMGVRVV TGISFGFVFY VLDQIFGPLT LVYGIPPIIG ALLPSASFFL
360
ISLWLLMRKS
Length:360
Mass (Da):39,619
Last modified:December 6, 2005 - v1
Checksum:i72BA4E01FE6167C9
GO

Sequence cautioni

The sequence AAA97159 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97159.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77219.2.
AP009048 Genomic DNA. Translation: BAE78259.1.
RefSeqiNP_418683.4. NC_000913.3.
WP_001295681.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77219; AAC77219; b4262.
BAE78259; BAE78259; BAE78259.
GeneIDi945324.
KEGGiecj:JW5760.
eco:b4262.
PATRICi32124097. VBIEscCol129921_4393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97159.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77219.2.
AP009048 Genomic DNA. Translation: BAE78259.1.
RefSeqiNP_418683.4. NC_000913.3.
WP_001295681.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ADC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262728. 224 interactors.
IntActiP0ADC6. 1 interactor.
MINTiMINT-7137015.
STRINGi511145.b4262.

Protein family/group databases

TCDBi1.B.42.1.2. the outer membrane lipopolysaccharide export porin (lps-ep) family.

Proteomic databases

PaxDbiP0ADC6.
PRIDEiP0ADC6.

Protocols and materials databases

DNASUi945324.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77219; AAC77219; b4262.
BAE78259; BAE78259; BAE78259.
GeneIDi945324.
KEGGiecj:JW5760.
eco:b4262.
PATRICi32124097. VBIEscCol129921_4393.

Organism-specific databases

EchoBASEiEB2425.
EcoGeneiEG12536. lptG.

Phylogenomic databases

eggNOGiENOG4108K5H. Bacteria.
COG0795. LUCA.
HOGENOMiHOG000263593.
InParanoidiP0ADC6.
KOiK11720.
OMAiFAYLHAR.
PhylomeDBiP0ADC6.

Enzyme and pathway databases

BioCyciEcoCyc:G7889-MONOMER.
ECOL316407:JW5760-MONOMER.
MetaCyc:G7889-MONOMER.

Miscellaneous databases

PROiP0ADC6.

Family and domain databases

InterProiIPR030923. LptG.
IPR005495. LptG/LptF_permease.
[Graphical view]
PfamiPF03739. YjgP_YjgQ. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04408. LptG_lptG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLPTG_ECOLI
AccessioniPrimary (citable) accession number: P0ADC6
Secondary accession number(s): P39341, Q2M647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.