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Protein

Lipoprotein-releasing system transmembrane protein LolC

Gene

lolC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA.

GO - Molecular functioni

GO - Biological processi

  • lipoprotein localization to outer membrane Source: EcoCyc
  • protein localization to outer membrane Source: CACAO

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YCFU-MONOMER.

Protein family/group databases

TCDBi3.A.1.125.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein-releasing system transmembrane protein LolC
Gene namesi
Name:lolC
Synonyms:ycfU
Ordered Locus Names:b1116, JW5161
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13439. lolC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
  • plasma membrane protein complex Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002018101 – 399Lipoprotein-releasing system transmembrane protein LolCAdd BLAST399

Proteomic databases

PaxDbiP0ADC3.
PRIDEiP0ADC3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lolAP613162EBI-15765497,EBI-553532

Protein-protein interaction databases

BioGridi4261911. 353 interactors.
DIPiDIP-58651N.
IntActiP0ADC3. 1 interactor.
STRINGi316385.ECDH10B_1188.

Structurei

3D structure databases

ProteinModelPortaliP0ADC3.
SMRiP0ADC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D60. Bacteria.
COG4591. LUCA.
HOGENOMiHOG000218040.
InParanoidiP0ADC3.
KOiK09808.
PhylomeDBiP0ADC3.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiView protein in InterPro
IPR003838. ABC_permease_dom.
IPR011925. LolCE_TM.
IPR025857. MacB_PCD.
IPR035906. MetI-like_sf.
PfamiView protein in Pfam
PF02687. FtsX. 1 hit.
PF12704. MacB_PCD. 1 hit.
TIGRFAMsiTIGR02212. lolCE. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ADC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQPVALFIG LRYMRGRAAD RFGRFVSWLS TIGITLGVMA LVTVLSVMNG
60 70 80 90 100
FERELQNNIL GLMPQAILSS EHGSLNPQQL PETAVKLDGV NRVAPITTGD
110 120 130 140 150
VVLQSARSVA VGVMLGIDPA QKDPLTPYLV NVKQTDLEPG KYNVILGEQL
160 170 180 190 200
ASQLGVNRGD QIRVMVPSAS QFTPMGRIPS QRLFNVIGTF AANSEVDGYE
210 220 230 240 250
MLVNIEDASR LMRYPAGNIT GWRLWLDEPL KVDSLSQQKL PEGSKWQDWR
260 270 280 290 300
DRKGELFQAV RMEKNMMGLL LSLIVAVAAF NIITSLGLMV MEKQGEVAIL
310 320 330 340 350
QTQGLTPRQI MMVFMVQGAS AGIIGAILGA ALGALLASQL NNLMPIIGVL
360 370 380 390
LDGAALPVAI EPLQVIVIAL VAMAIALLST LYPSWRAAAT QPAEALRYE
Length:399
Mass (Da):43,264
Last modified:December 6, 2005 - v1
Checksum:iA2BA2D6AF797A09A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74200.1.
AP009048 Genomic DNA. Translation: BAA35936.2.
PIRiA64856.
RefSeqiNP_415634.1. NC_000913.3.
WP_000284714.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74200; AAC74200; b1116.
BAA35936; BAA35936; BAA35936.
GeneIDi945673.
KEGGiecj:JW5161.
eco:b1116.
PATRICifig|1411691.4.peg.1151.

Similar proteinsi

Entry informationi

Entry nameiLOLC_ECOLI
AccessioniPrimary (citable) accession number: P0ADC3
Secondary accession number(s): P75956, Q9R7N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families