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Protein

Lipoprotein-releasing system transmembrane protein LolC

Gene

lolC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA.

GO - Molecular functioni

GO - Biological processi

  • lipoprotein localization to outer membrane Source: EcoCyc
  • protein localization to outer membrane Source: CACAO

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YCFU-MONOMER

Protein family/group databases

TCDBi3.A.1.125.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein-releasing system transmembrane protein LolC
Gene namesi
Name:lolC
Synonyms:ycfU
Ordered Locus Names:b1116, JW5161
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13439 lolC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
  • plasma membrane protein complex Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002018101 – 399Lipoprotein-releasing system transmembrane protein LolCAdd BLAST399

Proteomic databases

PaxDbiP0ADC3
PRIDEiP0ADC3

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lolAP613162EBI-15765497,EBI-553532

Protein-protein interaction databases

BioGridi4261911, 381 interactors
DIPiDIP-58651N
IntActiP0ADC3, 1 interactor
STRINGi316385.ECDH10B_1188

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi51 – 58Combined sources8
Helixi60 – 62Combined sources3
Beta strandi65 – 73Combined sources9
Turni77 – 79Combined sources3
Helixi82 – 84Combined sources3
Beta strandi88 – 104Combined sources17
Beta strandi109 – 117Combined sources9
Helixi126 – 128Combined sources3
Beta strandi129 – 131Combined sources3
Helixi134 – 136Combined sources3
Beta strandi143 – 147Combined sources5
Helixi148 – 154Combined sources7
Beta strandi161 – 171Combined sources11
Beta strandi178 – 190Combined sources13
Helixi195 – 198Combined sources4
Beta strandi200 – 204Combined sources5
Helixi205 – 211Combined sources7
Beta strandi219 – 227Combined sources9
Helixi229 – 231Combined sources3
Helixi232 – 235Combined sources4
Beta strandi244 – 248Combined sources5
Helixi249 – 251Combined sources3
Helixi254 – 266Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NAAX-ray1.88A/B48-266[»]
ProteinModelPortaliP0ADC3
SMRiP0ADC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D60 Bacteria
COG4591 LUCA
HOGENOMiHOG000218040
InParanoidiP0ADC3
KOiK09808
OMAiERNVMFL
PhylomeDBiP0ADC3

Family and domain databases

InterProiView protein in InterPro
IPR003838 ABC_permease_dom
IPR011925 LolCE_TM
IPR025857 MacB_PCD
PfamiView protein in Pfam
PF02687 FtsX, 1 hit
PF12704 MacB_PCD, 1 hit
TIGRFAMsiTIGR02212 lolCE, 1 hit

Sequencei

Sequence statusi: Complete.

P0ADC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQPVALFIG LRYMRGRAAD RFGRFVSWLS TIGITLGVMA LVTVLSVMNG
60 70 80 90 100
FERELQNNIL GLMPQAILSS EHGSLNPQQL PETAVKLDGV NRVAPITTGD
110 120 130 140 150
VVLQSARSVA VGVMLGIDPA QKDPLTPYLV NVKQTDLEPG KYNVILGEQL
160 170 180 190 200
ASQLGVNRGD QIRVMVPSAS QFTPMGRIPS QRLFNVIGTF AANSEVDGYE
210 220 230 240 250
MLVNIEDASR LMRYPAGNIT GWRLWLDEPL KVDSLSQQKL PEGSKWQDWR
260 270 280 290 300
DRKGELFQAV RMEKNMMGLL LSLIVAVAAF NIITSLGLMV MEKQGEVAIL
310 320 330 340 350
QTQGLTPRQI MMVFMVQGAS AGIIGAILGA ALGALLASQL NNLMPIIGVL
360 370 380 390
LDGAALPVAI EPLQVIVIAL VAMAIALLST LYPSWRAAAT QPAEALRYE
Length:399
Mass (Da):43,264
Last modified:December 6, 2005 - v1
Checksum:iA2BA2D6AF797A09A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74200.1
AP009048 Genomic DNA Translation: BAA35936.2
PIRiA64856
RefSeqiNP_415634.1, NC_000913.3
WP_000284714.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74200; AAC74200; b1116
BAA35936; BAA35936; BAA35936
GeneIDi945673
KEGGiecj:JW5161
eco:b1116
PATRICifig|1411691.4.peg.1151

Similar proteinsi

Entry informationi

Entry nameiLOLC_ECOLI
AccessioniPrimary (citable) accession number: P0ADC3
Secondary accession number(s): P75956, Q9R7N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health