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P0ADA2

- TESA_ECOL6

UniProt

P0ADA2 - TESA_ECOL6

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Protein
Acyl-CoA thioesterase I
Gene
tesA, c0615
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes only long chain acyl thioesters (C12-C18). Specificity similar to chymotrypsin By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361Nucleophile By similarity
Binding sitei70 – 701Substrate; via amide nitrogen By similarity
Binding sitei99 – 991Substrate By similarity
Active sitei180 – 1801 By similarity
Active sitei183 – 1831 By similarity

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
  2. peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. lipid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA thioesterase I (EC:3.1.2.-)
Alternative name(s):
Lecithinase B
Lysophospholipase L1 (EC:3.1.1.5)
Protease I
Gene namesi
Name:tesA
Ordered Locus Names:c0615
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 208182Acyl-CoA thioesterase I
PRO_0000043365Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi199310.c0615.

Structurei

3D structure databases

ProteinModelPortaliP0ADA2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000261382.
KOiK10804.
OMAiLENSRIW.
OrthoDBiEOG6PGK4B.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR001087. Lipase_GDSL.
IPR008265. Lipase_GDSL_AS.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]
PfamiPF00657. Lipase_GDSL. 1 hit.
[Graphical view]
PROSITEiPS01098. LIPASE_GDSL_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ADA2-1 [UniParc]FASTAAdd to Basket

« Hide

MMNFNNVFRW HLPFLFLVLL TFRAAAADTL LILGDSLSAG YRMSASAAWP    50
ALLNDKWQSK TSVVNASISG DTSQQGLARL PALLKQHQPR WVLVELGGND 100
GLRGFQPQQT EQTLRQILQD VKAANAEPLL MQIRLPANYG RRYNEAFSAI 150
YPKLAKEFDV PLLPFFMEEV YLKPQWMQDD GIHPNRDAQP FIADWMAKQL 200
QPLVNHDS 208
Length:208
Mass (Da):23,622
Last modified:December 6, 2005 - v1
Checksum:iCD03F23EA39541F1
GO

Sequence cautioni

The sequence AAN79092.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN79092.1. Different initiation.
RefSeqiNP_752548.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN79092; AAN79092; c0615.
GeneIDi1036492.
KEGGiecc:c0615.
PATRICi18279271. VBIEscCol75197_0580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN79092.1 . Different initiation.
RefSeqi NP_752548.1. NC_004431.1.

3D structure databases

ProteinModelPortali P0ADA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c0615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN79092 ; AAN79092 ; c0615 .
GeneIDi 1036492.
KEGGi ecc:c0615.
PATRICi 18279271. VBIEscCol75197_0580.

Phylogenomic databases

HOGENOMi HOG000261382.
KOi K10804.
OMAi LENSRIW.
OrthoDBi EOG6PGK4B.

Family and domain databases

Gene3Di 3.40.50.1110. 1 hit.
InterProi IPR001087. Lipase_GDSL.
IPR008265. Lipase_GDSL_AS.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
Pfami PF00657. Lipase_GDSL. 1 hit.
[Graphical view ]
PROSITEi PS01098. LIPASE_GDSL_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiTESA_ECOL6
AccessioniPrimary (citable) accession number: P0ADA2
Secondary accession number(s): P29679, P37331, P77125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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