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Protein

Acyl-CoA thioesterase I

Gene

tesA

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes only long chain acyl thioesters (C12-C18). Specificity similar to chymotrypsin (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36NucleophileBy similarity1
Binding sitei70Substrate; via amide nitrogenBy similarity1
Binding sitei99SubstrateBy similarity1
Active sitei180By similarity1
Active sitei183By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA thioesterase I (EC:3.1.2.-)
Alternative name(s):
Lecithinase B
Lysophospholipase L1 (EC:3.1.1.5)
Protease I
Gene namesi
Name:tesA
Ordered Locus Names:c0615
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000004336527 – 208Acyl-CoA thioesterase IAdd BLAST182

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi199310.c0615.

Structurei

3D structure databases

ProteinModelPortaliP0ADA2.
SMRiP0ADA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'GDSL' lipolytic enzyme family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108UJV. Bacteria.
COG2755. LUCA.
HOGENOMiHOG000261382.
KOiK10804.
OMAiPPNYGPD.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR008265. Lipase_GDSL_AS.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
PROSITEiPS01098. LIPASE_GDSL_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ADA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNFNNVFRW HLPFLFLVLL TFRAAAADTL LILGDSLSAG YRMSASAAWP
60 70 80 90 100
ALLNDKWQSK TSVVNASISG DTSQQGLARL PALLKQHQPR WVLVELGGND
110 120 130 140 150
GLRGFQPQQT EQTLRQILQD VKAANAEPLL MQIRLPANYG RRYNEAFSAI
160 170 180 190 200
YPKLAKEFDV PLLPFFMEEV YLKPQWMQDD GIHPNRDAQP FIADWMAKQL

QPLVNHDS
Length:208
Mass (Da):23,622
Last modified:December 6, 2005 - v1
Checksum:iCD03F23EA39541F1
GO

Sequence cautioni

The sequence AAN79092 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN79092.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiAAN79092; AAN79092; c0615.
KEGGiecc:c0615.
PATRICi18279271. VBIEscCol75197_0580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN79092.1. Different initiation.

3D structure databases

ProteinModelPortaliP0ADA2.
SMRiP0ADA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c0615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN79092; AAN79092; c0615.
KEGGiecc:c0615.
PATRICi18279271. VBIEscCol75197_0580.

Phylogenomic databases

eggNOGiENOG4108UJV. Bacteria.
COG2755. LUCA.
HOGENOMiHOG000261382.
KOiK10804.
OMAiPPNYGPD.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR008265. Lipase_GDSL_AS.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
PROSITEiPS01098. LIPASE_GDSL_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTESA_ECOL6
AccessioniPrimary (citable) accession number: P0ADA2
Secondary accession number(s): P29679, P37331, P77125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.