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P0ADA2

- TESA_ECOL6

UniProt

P0ADA2 - TESA_ECOL6

Protein

Acyl-CoA thioesterase I

Gene

tesA

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Hydrolyzes only long chain acyl thioesters (C12-C18). Specificity similar to chymotrypsin By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei36 – 361NucleophileBy similarity
    Binding sitei70 – 701Substrate; via amide nitrogenBy similarity
    Binding sitei99 – 991SubstrateBy similarity
    Active sitei180 – 1801By similarity
    Active sitei183 – 1831By similarity

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC
    2. peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-CoA thioesterase I (EC:3.1.2.-)
    Alternative name(s):
    Lecithinase B
    Lysophospholipase L1 (EC:3.1.1.5)
    Protease I
    Gene namesi
    Name:tesA
    Ordered Locus Names:c0615
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 208182Acyl-CoA thioesterase IPRO_0000043365Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi199310.c0615.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ADA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 'GDSL' lipolytic enzyme family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000261382.
    KOiK10804.
    OMAiLENSRIW.
    OrthoDBiEOG6PGK4B.

    Family and domain databases

    Gene3Di3.40.50.1110. 1 hit.
    InterProiIPR001087. Lipase_GDSL.
    IPR008265. Lipase_GDSL_AS.
    IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view]
    PfamiPF00657. Lipase_GDSL. 1 hit.
    [Graphical view]
    PROSITEiPS01098. LIPASE_GDSL_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0ADA2-1 [UniParc]FASTAAdd to Basket

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    MMNFNNVFRW HLPFLFLVLL TFRAAAADTL LILGDSLSAG YRMSASAAWP    50
    ALLNDKWQSK TSVVNASISG DTSQQGLARL PALLKQHQPR WVLVELGGND 100
    GLRGFQPQQT EQTLRQILQD VKAANAEPLL MQIRLPANYG RRYNEAFSAI 150
    YPKLAKEFDV PLLPFFMEEV YLKPQWMQDD GIHPNRDAQP FIADWMAKQL 200
    QPLVNHDS 208
    Length:208
    Mass (Da):23,622
    Last modified:December 6, 2005 - v1
    Checksum:iCD03F23EA39541F1
    GO

    Sequence cautioni

    The sequence AAN79092.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79092.1. Different initiation.
    RefSeqiNP_752548.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN79092; AAN79092; c0615.
    GeneIDi1036492.
    KEGGiecc:c0615.
    PATRICi18279271. VBIEscCol75197_0580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79092.1 . Different initiation.
    RefSeqi NP_752548.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali P0ADA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c0615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN79092 ; AAN79092 ; c0615 .
    GeneIDi 1036492.
    KEGGi ecc:c0615.
    PATRICi 18279271. VBIEscCol75197_0580.

    Phylogenomic databases

    HOGENOMi HOG000261382.
    KOi K10804.
    OMAi LENSRIW.
    OrthoDBi EOG6PGK4B.

    Family and domain databases

    Gene3Di 3.40.50.1110. 1 hit.
    InterProi IPR001087. Lipase_GDSL.
    IPR008265. Lipase_GDSL_AS.
    IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view ]
    Pfami PF00657. Lipase_GDSL. 1 hit.
    [Graphical view ]
    PROSITEi PS01098. LIPASE_GDSL_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiTESA_ECOL6
    AccessioniPrimary (citable) accession number: P0ADA2
    Secondary accession number(s): P29679, P37331, P77125
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3