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Protein

Thioesterase 1/protease 1/lysophospholipase L1

Gene

tesA

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

TesA is a multifunctional esterase that can act as a thioesterase, arylesterase, lysophospholipase and protease.By similarity

Catalytic activityi

Palmitoyl-CoA + H2O = CoA + palmitate.By similarity
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity
A phenyl acetate + H2O = a phenol + acetate.By similarity
Oleoyl-[acyl-carrier-protein] + H2O = [acyl-carrier-protein] + oleate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36NucleophileBy similarity1
Binding sitei70Substrate; via amide nitrogenBy similarity1
Binding sitei99SubstrateBy similarity1
Active sitei180By similarity1
Active sitei183By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Thioesterase 1/protease 1/lysophospholipase L1By similarity
Short name:
TAPBy similarity
Alternative name(s):
Acyl-CoA thioesterase 1By similarity (EC:3.1.2.2By similarity)
Short name:
TESABy similarity
Acyl-CoA thioesterase IBy similarity
ArylesteraseBy similarity (EC:3.1.1.2By similarity)
Lysophospholipase L1By similarity (EC:3.1.1.5By similarity)
Oleoyl-[acyl-carrier-protein] hydrolaseBy similarity (EC:3.1.2.14By similarity)
Phospholipid degradation CBy similarity
Short name:
PldcBy similarity
Protease 1By similarity (EC:3.4.21.-By similarity)
Protease IBy similarity
Thioesterase I/protease IBy similarity
Short name:
TEP-IBy similarity
Gene namesi
Name:tesA
Ordered Locus Names:c0615
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

Subcellular locationi

  • Periplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000004336527 – 208Thioesterase 1/protease 1/lysophospholipase L1Add BLAST182

Interactioni

Subunit structurei

Monomer or homotetramer.By similarity

Protein-protein interaction databases

STRINGi199310.c0615.

Structurei

3D structure databases

ProteinModelPortaliP0ADA2.
SMRiP0ADA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'GDSL' lipolytic enzyme family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108UJV. Bacteria.
COG2755. LUCA.
HOGENOMiHOG000261382.
KOiK10804.
OMAiQPDGIHP.

Family and domain databases

InterProiView protein in InterPro
IPR008265. Lipase_GDSL_AS.
IPR013830. SGNH_hydro.
PfamiView protein in Pfam
PF13472. Lipase_GDSL_2. 1 hit.
SUPFAMiSSF52266. SSF52266. 1 hit.
PROSITEiView protein in PROSITE
PS01098. LIPASE_GDSL_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ADA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNFNNVFRW HLPFLFLVLL TFRAAAADTL LILGDSLSAG YRMSASAAWP
60 70 80 90 100
ALLNDKWQSK TSVVNASISG DTSQQGLARL PALLKQHQPR WVLVELGGND
110 120 130 140 150
GLRGFQPQQT EQTLRQILQD VKAANAEPLL MQIRLPANYG RRYNEAFSAI
160 170 180 190 200
YPKLAKEFDV PLLPFFMEEV YLKPQWMQDD GIHPNRDAQP FIADWMAKQL

QPLVNHDS
Length:208
Mass (Da):23,622
Last modified:December 6, 2005 - v1
Checksum:iCD03F23EA39541F1
GO

Sequence cautioni

The sequence AAN79092 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN79092.1. Different initiation.
RefSeqiWP_001297298.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN79092; AAN79092; c0615.
KEGGiecc:c0615.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTESA_ECOL6
AccessioniPrimary (citable) accession number: P0ADA2
Secondary accession number(s): P29679, P37331, P77125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: June 7, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families