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Protein

Branched-chain amino acid transport system 2 carrier protein

Gene

brnQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the LIV-II transport system for branched-chain amino acids. This LIV-II transport system may be H+-coupled.

GO - Molecular functioni

  • L-isoleucine transmembrane transporter activity Source: EcoCyc
  • L-leucine transmembrane transporter activity Source: EcoCyc
  • L-valine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • branched-chain amino acid transport Source: EcoliWiki
  • isoleucine transport Source: EcoliWiki
  • leucine transport Source: EcoliWiki
  • valine transport Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:BRNQ-MONOMER.
ECOL316407:JW0391-MONOMER.
MetaCyc:BRNQ-MONOMER.

Protein family/group databases

TCDBi2.A.26.1.10. the branched chain amino acid:cation symporter (livcs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Branched-chain amino acid transport system 2 carrier protein
Alternative name(s):
LIV-II
Gene namesi
Name:brnQ
Ordered Locus Names:b0401, JW0391
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12168. brnQ.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 45PeriplasmicSequence analysisAdd BLAST15
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 79CytoplasmicSequence analysisAdd BLAST13
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 118PeriplasmicSequence analysisAdd BLAST18
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 149CytoplasmicSequence analysis10
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 189PeriplasmicSequence analysisAdd BLAST19
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 226CytoplasmicSequence analysisAdd BLAST16
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 277PeriplasmicSequence analysisAdd BLAST30
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 316CytoplasmicSequence analysisAdd BLAST18
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338PeriplasmicSequence analysis1
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 369CytoplasmicSequence analysis10
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 404PeriplasmicSequence analysisAdd BLAST14
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 439CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000997651 – 439Branched-chain amino acid transport system 2 carrier proteinAdd BLAST439

Proteomic databases

PaxDbiP0AD99.
PRIDEiP0AD99.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
pheSP083123EBI-555687,EBI-555676

Protein-protein interaction databases

BioGridi4259819. 6 interactors.
DIPiDIP-48078N.
IntActiP0AD99. 1 interactor.
MINTiMINT-1238115.
STRINGi511145.b0401.

Structurei

3D structure databases

ProteinModelPortaliP0AD99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CWM. Bacteria.
COG1114. LUCA.
HOGENOMiHOG000270688.
InParanoidiP0AD99.
KOiK03311.
OMAiYSLIYFA.
PhylomeDBiP0AD99.

Family and domain databases

InterProiIPR004685. Brnchd-chn_aa_trnsp_Livcs.
[Graphical view]
PANTHERiPTHR30588. PTHR30588. 1 hit.
PfamiPF05525. Branch_AA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00796. livcs. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AD99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQLRSRDI IALGFMTFAL FVGAGNIIFP PMVGLQAGEH VWTAAFGFLI
60 70 80 90 100
TAVGLPVLTV VALAKVGGGV DSLSTPIGKV AGVLLATVCY LAVGPLFATP
110 120 130 140 150
RTATVSFEVG IAPLTGDSAL PLFIYSLVYF AIVILVSLYP GKLLDTVGNF
160 170 180 190 200
LAPLKIIALV ILSVAAIVWP AGSISTATEA YQNAAFSNGF VNGYLTMDTL
210 220 230 240 250
GAMVFGIVIV NAARSRGVTE ARLLTRYTVW AGLMAGVGLT LLYLALFRLG
260 270 280 290 300
SDSASLVDQS ANGAAILHAY VQHTFGGGGS FLLAALIFIA CLVTAVGLTC
310 320 330 340 350
ACAEFFAQYV PLSYRTLVFI LGGFSMVVSN LGLSQLIQIS VPVLTAIYPP
360 370 380 390 400
CIALVVLSFT RSWWHNSSRV IAPPMFISLL FGILDGIKAS AFSDILPSWA
410 420 430
QRLPLAEQGL AWLMPTVVMV VLAIIWDRAA GRQVTSSAH
Length:439
Mass (Da):46,209
Last modified:December 6, 2005 - v1
Checksum:iB30C3B5755738E0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18125.1.
U82664 Genomic DNA. Translation: AAB40157.1.
U00096 Genomic DNA. Translation: AAC73504.1.
AP009048 Genomic DNA. Translation: BAE76181.1.
X04704 Genomic DNA. No translation available.
PIRiA64769.
RefSeqiNP_414935.1. NC_000913.3.
WP_000149639.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73504; AAC73504; b0401.
BAE76181; BAE76181; BAE76181.
GeneIDi945042.
KEGGiecj:JW0391.
eco:b0401.
PATRICi32115951. VBIEscCol129921_0417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18125.1.
U82664 Genomic DNA. Translation: AAB40157.1.
U00096 Genomic DNA. Translation: AAC73504.1.
AP009048 Genomic DNA. Translation: BAE76181.1.
X04704 Genomic DNA. No translation available.
PIRiA64769.
RefSeqiNP_414935.1. NC_000913.3.
WP_000149639.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AD99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259819. 6 interactors.
DIPiDIP-48078N.
IntActiP0AD99. 1 interactor.
MINTiMINT-1238115.
STRINGi511145.b0401.

Protein family/group databases

TCDBi2.A.26.1.10. the branched chain amino acid:cation symporter (livcs) family.

Proteomic databases

PaxDbiP0AD99.
PRIDEiP0AD99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73504; AAC73504; b0401.
BAE76181; BAE76181; BAE76181.
GeneIDi945042.
KEGGiecj:JW0391.
eco:b0401.
PATRICi32115951. VBIEscCol129921_0417.

Organism-specific databases

EchoBASEiEB2087.
EcoGeneiEG12168. brnQ.

Phylogenomic databases

eggNOGiENOG4105CWM. Bacteria.
COG1114. LUCA.
HOGENOMiHOG000270688.
InParanoidiP0AD99.
KOiK03311.
OMAiYSLIYFA.
PhylomeDBiP0AD99.

Enzyme and pathway databases

BioCyciEcoCyc:BRNQ-MONOMER.
ECOL316407:JW0391-MONOMER.
MetaCyc:BRNQ-MONOMER.

Miscellaneous databases

PROiP0AD99.

Family and domain databases

InterProiIPR004685. Brnchd-chn_aa_trnsp_Livcs.
[Graphical view]
PANTHERiPTHR30588. PTHR30588. 1 hit.
PfamiPF05525. Branch_AA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00796. livcs. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBRNQ_ECOLI
AccessioniPrimary (citable) accession number: P0AD99
Secondary accession number(s): P37011
, P77112, P77492, Q2MC25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.