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Protein

Tryptophanase leader peptide

Gene

tnaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for tryptophan-regulated expression of the tna operon. In the presence of free L-Trp release of this nascent peptide by release factor 2 is inhibited and the ribosome stalls with the last amino acid in the P site and a UGA stop codon in the A site. This prevent transcripiton termination factor Rho binding, and thus allows transcription and translation of TnaA and TnaB.1 Publication

GO - Biological processi

  • transcriptional attenuation by ribosome Source: EcoCyc
  • tryptophan catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Leader peptide

Enzyme and pathway databases

BioCyciEcoCyc:EG11276-MONOMER.
ECOL316407:JW3685-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophanase leader peptide
Gene namesi
Name:tnaC
Synonyms:tnaL
Ordered Locus Names:b3707, JW3685
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11276. tnaL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2424Tryptophanase leader peptidePRO_0000044011Add
BLAST

Proteomic databases

PaxDbiP0AD89.

Interactioni

Protein-protein interaction databases

BioGridi4262592. 20 interactions.
STRINGi511145.b3707.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UY8electron microscopy3.8075-24[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR012620. Trp_operon_leader_peptide.
[Graphical view]
PfamiPF08053. Tna_leader. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02616. tnaC_leader. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AD89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MNILHICVTS KWFNIDNKIV DHRP
Length:24
Mass (Da):2,894
Last modified:December 6, 2005 - v1
Checksum:i66E3987EA7C052F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11990 Genomic DNA. Translation: AAA24678.1.
L10328 Genomic DNA. Translation: AAA62058.1.
U00096 Genomic DNA. Translation: AAC76730.1.
AP009048 Genomic DNA. Translation: BAE77586.1.
PIRiI54862.
RefSeqiNP_418163.1. NC_000913.3.
WP_001364348.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76730; AAC76730; b3707.
BAE77586; BAE77586; BAE77586.
GeneIDi948223.
KEGGiecj:JW3685.
eco:b3707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11990 Genomic DNA. Translation: AAA24678.1.
L10328 Genomic DNA. Translation: AAA62058.1.
U00096 Genomic DNA. Translation: AAC76730.1.
AP009048 Genomic DNA. Translation: BAE77586.1.
PIRiI54862.
RefSeqiNP_418163.1. NC_000913.3.
WP_001364348.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UY8electron microscopy3.8075-24[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262592. 20 interactions.
STRINGi511145.b3707.

Proteomic databases

PaxDbiP0AD89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76730; AAC76730; b3707.
BAE77586; BAE77586; BAE77586.
GeneIDi948223.
KEGGiecj:JW3685.
eco:b3707.

Organism-specific databases

EchoBASEiEB1254.
EcoGeneiEG11276. tnaL.

Enzyme and pathway databases

BioCyciEcoCyc:EG11276-MONOMER.
ECOL316407:JW3685-MONOMER.

Miscellaneous databases

PROiP0AD89.

Family and domain databases

InterProiIPR012620. Trp_operon_leader_peptide.
[Graphical view]
PfamiPF08053. Tna_leader. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02616. tnaC_leader. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLPTN_ECOLI
AccessioniPrimary (citable) accession number: P0AD89
Secondary accession number(s): P09408, Q2M820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: January 20, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.