P0AD86 (LPT_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thr operon leader peptide

Alternative name(s):
Thr operon attenuator

Gene names

Name:	thrL
Ordered Locus Names:	b0001, JW4367

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	21 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in control of the biosynthesis of threonine. HAMAP MF_01907
Sequence similarities	Belongs to the Thr operon leader peptide family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Molecular function	Leader peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW transcriptional attenuation by ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 21	21	Thr operon leader peptide HAMAP MF_01907		PRO_0000044007

Sequences

	Sequence		Length	Mass (Da)
	P0AD86 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 6A9C9167F89EECE4	FASTA	21	2,138
	10 20 MKRISTTITT TITITTGNGA G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Regulation of the threonine operon: tandem threonine and isoleucine codons in the control region and translational control of transcription termination." Gardner J.F. Proc. Natl. Acad. Sci. U.S.A. 76:1706-1710(1979) [PubMed: 287010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Initiation, pausing, and termination of transcription in the threonine operon regulatory region of Escherichia coli." Gardner J.F. J. Biol. Chem. 257:3896-3904(1982) [PubMed: 6277952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Identification and characterization of mutants affecting transcription termination at the threonine operon attenuator." Lynn S.P., Bauer C.E., Chapman K.A., Gardner J.F. J. Mol. Biol. 183:529-541(1985) [PubMed: 2410621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed: 7610040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[5]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[6]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J01706 Genomic DNA. Translation: AAA83913.1. V00360 Genomic DNA. Translation: CAA23658.1. X68872 Genomic DNA. Translation: CAA48733.1. M28570 Genomic DNA. Translation: AAA24672.1. U14003 Genomic DNA. Translation: AAA97300.1. U00096 Genomic DNA. Translation: AAC73112.1. AP009048 Genomic DNA. Translation: BAE76026.1.
PIR	LFECT. A03595.
RefSeq	NP_414542.1. NC_000913.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000001087; EBESCP00000001087; EBESCG00000000900. EBESCT00000014488; EBESCP00000013779; EBESCG00000013549.
GeneID	944742.
GenomeReviews	Gene locus JW4367 in contig AP009048_GR. Gene locus b0001 in contig U00096_GR.
KEGG	ecj:JW4367. eco:b0001.
Organism-specific databases
EchoBASE	EB1255.
EcoGene	EG11277. thrL.
Phylogenomic databases
HOGENOM	HBG086366.
ProtClustDB	PRK09816.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11277-MONOMER.
Gene expression databases
Genevestigator	P0AD86.
Family and domain databases
HAMAP	MF_01907. Leader_Thr. [Tree]
InterPro	IPR011720. Thr_lead_pept. [Graphical view]
KO	K08278.
Pfam	PF08254. Leader_Thr. 1 hit. [Graphical view]
TIGRFAMs	TIGR02077. Thr_lead_pep. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPT_ECOLI

Accession

Primary (citable) accession number: P0AD86
Secondary accession number(s): P03059, Q2MCI0, Q6LEL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program