##gff-version 3 P0AD61 UniProtKB Chain 1 470 . . . ID=PRO_0000112069;Note=Pyruvate kinase I P0AD61 UniProtKB Binding site 32 32 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 34 37 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P0AD61 UniProtKB Binding site 34 34 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 36 36 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 66 66 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 67 67 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 73 73 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P0AD61 UniProtKB Binding site 156 156 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P0AD61 UniProtKB Binding site 220 220 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 222 222 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 245 245 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 246 246 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 246 246 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Binding site 278 278 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P0AD61 UniProtKB Site 220 220 . . . Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00549 P0AD61 UniProtKB Modified residue 76 76 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18723842;Dbxref=PMID:18723842 P0AD61 UniProtKB Modified residue 319 319 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18723842;Dbxref=PMID:18723842 P0AD61 UniProtKB Mutagenesis 271 271 . . . Note=Loss of an interdomain salt bridge%2C stablilizes the inactive T-state. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10751408;Dbxref=PMID:10751408 P0AD61 UniProtKB Mutagenesis 292 292 . . . Note=Inactive%2C crystallizes in the inactive form. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10751408;Dbxref=PMID:10751408 P0AD61 UniProtKB Mutagenesis 297 297 . . . Note=Inactive. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10751408;Dbxref=PMID:10751408 P0AD61 UniProtKB Mutagenesis 382 382 . . . Note=Significant loss of activation by fructose 1%2C6-bisphosphate%2C retains sigmoidal kinetics. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10751408;Dbxref=PMID:10751408 P0AD61 UniProtKB Mutagenesis 413 413 . . . Note=Partial activation of enzyme%2C loss of cooperativity in fructose 1%2C6-bisphosphate binding. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10751408;Dbxref=PMID:10751408 P0AD61 UniProtKB Mutagenesis 431 431 . . . Note=Partial activation. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10751408;Dbxref=PMID:10751408 P0AD61 UniProtKB Sequence conflict 44 44 . . . Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P0AD61 UniProtKB Sequence conflict 379 379 . . . Note=Q->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 P0AD61 UniProtKB Sequence conflict 401 401 . . . Note=T->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 P0AD61 UniProtKB Sequence conflict 451 470 . . . Note=MVSGALVPSGTTNTASVHVL->YGFWCTGTERHY;Ontology_term=ECO:0000305;evidence=ECO:0000305 P0AD61 UniProtKB Beta strand 4 9 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 12 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 17 26 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 28 34 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 40 57 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 62 66 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 72 74 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 78 80 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 83 85 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 90 95 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 105 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 113 116 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 122 125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Turn 126 129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 130 138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 141 146 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 150 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 157 159 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 172 184 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 187 193 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 197 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Turn 209 211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 216 221 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 224 228 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 230 236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 237 243 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 244 250 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 253 270 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 273 277 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 278 281 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1PKY P0AD61 UniProtKB Helix 282 285 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8EDT P0AD61 UniProtKB Helix 292 304 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 307 311 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 313 316 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8EDT P0AD61 UniProtKB Helix 322 336 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 350 352 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8EDS P0AD61 UniProtKB Helix 355 368 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 372 377 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 379 381 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 382 388 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 393 401 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 403 408 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 409 411 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 415 419 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Helix 426 439 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 441 443 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 448 453 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 455 457 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T P0AD61 UniProtKB Beta strand 464 469 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1E0T