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P0AD59

- IVY_ECOLI

UniProt

P0AD59 - IVY_ECOLI

Protein

Inhibitor of vertebrate lysozyme

Gene

ivy

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Strong inhibitor of lysozyme C.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei88 – 881Important for lysozyme inhibition

    GO - Molecular functioni

    1. lysozyme inhibitor activity Source: EcoCyc

    GO - Biological processi

    1. regulation of catalytic activity Source: EcoCyc

    Enzyme and pathway databases

    BioCyciEcoCyc:G6104-MONOMER.
    ECOL316407:JW0210-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inhibitor of vertebrate lysozyme
    Gene namesi
    Name:ivy
    Synonyms:ykfE
    Ordered Locus Names:b0220, JW0210
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13547. ivy.

    Subcellular locationi

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28282 PublicationsAdd
    BLAST
    Chaini29 – 157129Inhibitor of vertebrate lysozymePRO_0000016546Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi85 ↔ 90

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP0AD59.
    PRIDEiP0AD59.

    2D gel databases

    SWISS-2DPAGEP0AD59.

    Expressioni

    Gene expression databases

    GenevestigatoriP0AD59.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    DIPiDIP-10051N.
    STRINGi511145.b0220.

    Structurei

    Secondary structure

    1
    157
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi34 – 396
    Turni41 – 433
    Helixi44 – 518
    Helixi59 – 624
    Beta strandi65 – 7511
    Beta strandi77 – 859
    Turni90 – 923
    Beta strandi93 – 997
    Turni101 – 1033
    Beta strandi106 – 1138
    Turni115 – 1173
    Beta strandi120 – 1256
    Helixi129 – 1313
    Helixi133 – 14412
    Helixi146 – 1494

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GPQX-ray1.60A/B29-156[»]
    1XS0X-ray1.58A/B/C29-156[»]
    ProteinModelPortaliP0AD59.
    SMRiP0AD59. Positions 30-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0AD59.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ivy family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG146309.
    HOGENOMiHOG000117011.
    OMAiDCAAQNI.
    OrthoDBiEOG68H883.

    Family and domain databases

    Gene3Di3.40.1420.10. 1 hit.
    InterProiIPR014453. Ihibitor_vertebrate_lysozyme.
    [Graphical view]
    PIRSFiPIRSF009103. Ivy. 1 hit.
    SUPFAMiSSF89872. SSF89872. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0AD59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRISSGGMM FKAITTVAAL VIATSAMAQD DLTISSLAKG ETTKAAFNQM    50
    VQGHKLPAWV MKGGTYTPAQ TVTLGDETYQ VMSACKPHDC GSQRIAVMWS 100
    EKSNQMTGLF STIDEKTSQE KLTWLNVNDA LSIDGKTVLF AALTGSLENH 150
    PDGFNFK 157
    Length:157
    Mass (Da):16,872
    Last modified:December 6, 2005 - v1
    Checksum:i9156C5944DFE6D84
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361Missing AA sequence (PubMed:9868784)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70214 Genomic DNA. Translation: AAB08642.1.
    U00096 Genomic DNA. Translation: AAC73324.1.
    AP009048 Genomic DNA. Translation: BAA77890.1.
    PIRiE64746.
    RefSeqiNP_414755.1. NC_000913.3.
    YP_488517.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73324; AAC73324; b0220.
    BAA77890; BAA77890; BAA77890.
    GeneIDi12932218.
    946530.
    KEGGiecj:Y75_p0211.
    eco:b0220.
    PATRICi32115555. VBIEscCol129921_0222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70214 Genomic DNA. Translation: AAB08642.1 .
    U00096 Genomic DNA. Translation: AAC73324.1 .
    AP009048 Genomic DNA. Translation: BAA77890.1 .
    PIRi E64746.
    RefSeqi NP_414755.1. NC_000913.3.
    YP_488517.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GPQ X-ray 1.60 A/B 29-156 [» ]
    1XS0 X-ray 1.58 A/B/C 29-156 [» ]
    ProteinModelPortali P0AD59.
    SMRi P0AD59. Positions 30-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-10051N.
    STRINGi 511145.b0220.

    2D gel databases

    SWISS-2DPAGE P0AD59.

    Proteomic databases

    PaxDbi P0AD59.
    PRIDEi P0AD59.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73324 ; AAC73324 ; b0220 .
    BAA77890 ; BAA77890 ; BAA77890 .
    GeneIDi 12932218.
    946530.
    KEGGi ecj:Y75_p0211.
    eco:b0220.
    PATRICi 32115555. VBIEscCol129921_0222.

    Organism-specific databases

    EchoBASEi EB3317.
    EcoGenei EG13547. ivy.

    Phylogenomic databases

    eggNOGi NOG146309.
    HOGENOMi HOG000117011.
    OMAi DCAAQNI.
    OrthoDBi EOG68H883.

    Enzyme and pathway databases

    BioCyci EcoCyc:G6104-MONOMER.
    ECOL316407:JW0210-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P0AD59.
    PROi P0AD59.

    Gene expression databases

    Genevestigatori P0AD59.

    Family and domain databases

    Gene3Di 3.40.1420.10. 1 hit.
    InterProi IPR014453. Ihibitor_vertebrate_lysozyme.
    [Graphical view ]
    PIRSFi PIRSF009103. Ivy. 1 hit.
    SUPFAMi SSF89872. SSF89872. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region."
      Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. Cited for: PROTEIN SEQUENCE OF 29-39.
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    6. "Small genes/gene-products in Escherichia coli K-12."
      Wasinger V.C., Humphery-Smith I.
      FEMS Microbiol. Lett. 169:375-382(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-38.
      Strain: K12.
    7. "Escherichia coli ykfE ORFan gene encodes a potent inhibitor of C-type lysozyme."
      Montchois V., Abergel C., Sturgis J., Jeudy S., Claverie J.-M.
      J. Biol. Chem. 276:18437-18441(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Strain: K12 / XL1-Blue.
    8. "Crystallization and preliminary crystallographic study of b0220, an 'ORFan' protein of unknown function from Escherichia coli."
      Abergel C., Monchois V., Chenivesse S., Jeudy S., Claverie J.-M.
      Acta Crystallogr. D 56:1694-1695(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CRYSTALLIZATION.
    9. "Structure and evolution of a paradoxical protein family of vertebrate lysozyme inhibitors only found in Gram-negative bacteria."
      Abergel C., Monchois V., Claverie J.-M.
      Submitted (NOV-2001) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

    Entry informationi

    Entry nameiIVY_ECOLI
    AccessioniPrimary (citable) accession number: P0AD59
    Secondary accession number(s): P45502, P77185
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3