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P0AD59

- IVY_ECOLI

UniProt

P0AD59 - IVY_ECOLI

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Protein

Inhibitor of vertebrate lysozyme

Gene
ivy, ykfE, b0220, JW0210
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Strong inhibitor of lysozyme C.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Important for lysozyme inhibition

GO - Molecular functioni

  1. lysozyme inhibitor activity Source: EcoCyc

GO - Biological processi

  1. regulation of catalytic activity Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6104-MONOMER.
ECOL316407:JW0210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of vertebrate lysozyme
Gene namesi
Name:ivy
Synonyms:ykfE
Ordered Locus Names:b0220, JW0210
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13547. ivy.

Subcellular locationi

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28282 PublicationsAdd
BLAST
Chaini29 – 157129Inhibitor of vertebrate lysozymePRO_0000016546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 90

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0AD59.
PRIDEiP0AD59.

2D gel databases

SWISS-2DPAGEP0AD59.

Expressioni

Gene expression databases

GenevestigatoriP0AD59.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi511145.b0220.

Structurei

Secondary structure

1
157
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 396
Turni41 – 433
Helixi44 – 518
Helixi59 – 624
Beta strandi65 – 7511
Beta strandi77 – 859
Turni90 – 923
Beta strandi93 – 997
Turni101 – 1033
Beta strandi106 – 1138
Turni115 – 1173
Beta strandi120 – 1256
Helixi129 – 1313
Helixi133 – 14412
Helixi146 – 1494

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GPQX-ray1.60A/B29-156[»]
1XS0X-ray1.58A/B/C29-156[»]
ProteinModelPortaliP0AD59.
SMRiP0AD59. Positions 30-156.

Miscellaneous databases

EvolutionaryTraceiP0AD59.

Family & Domainsi

Sequence similaritiesi

Belongs to the ivy family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG146309.
HOGENOMiHOG000117011.
OMAiDCAAQNI.
OrthoDBiEOG68H883.

Family and domain databases

Gene3Di3.40.1420.10. 1 hit.
InterProiIPR014453. Ihibitor_vertebrate_lysozyme.
[Graphical view]
PIRSFiPIRSF009103. Ivy. 1 hit.
SUPFAMiSSF89872. SSF89872. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AD59-1 [UniParc]FASTAAdd to Basket

« Hide

MGRISSGGMM FKAITTVAAL VIATSAMAQD DLTISSLAKG ETTKAAFNQM    50
VQGHKLPAWV MKGGTYTPAQ TVTLGDETYQ VMSACKPHDC GSQRIAVMWS 100
EKSNQMTGLF STIDEKTSQE KLTWLNVNDA LSIDGKTVLF AALTGSLENH 150
PDGFNFK 157
Length:157
Mass (Da):16,872
Last modified:December 6, 2005 - v1
Checksum:i9156C5944DFE6D84
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361Missing AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70214 Genomic DNA. Translation: AAB08642.1.
U00096 Genomic DNA. Translation: AAC73324.1.
AP009048 Genomic DNA. Translation: BAA77890.1.
PIRiE64746.
RefSeqiNP_414755.1. NC_000913.3.
YP_488517.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73324; AAC73324; b0220.
BAA77890; BAA77890; BAA77890.
GeneIDi12932218.
946530.
KEGGiecj:Y75_p0211.
eco:b0220.
PATRICi32115555. VBIEscCol129921_0222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70214 Genomic DNA. Translation: AAB08642.1 .
U00096 Genomic DNA. Translation: AAC73324.1 .
AP009048 Genomic DNA. Translation: BAA77890.1 .
PIRi E64746.
RefSeqi NP_414755.1. NC_000913.3.
YP_488517.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GPQ X-ray 1.60 A/B 29-156 [» ]
1XS0 X-ray 1.58 A/B/C 29-156 [» ]
ProteinModelPortali P0AD59.
SMRi P0AD59. Positions 30-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 511145.b0220.

2D gel databases

SWISS-2DPAGE P0AD59.

Proteomic databases

PaxDbi P0AD59.
PRIDEi P0AD59.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73324 ; AAC73324 ; b0220 .
BAA77890 ; BAA77890 ; BAA77890 .
GeneIDi 12932218.
946530.
KEGGi ecj:Y75_p0211.
eco:b0220.
PATRICi 32115555. VBIEscCol129921_0222.

Organism-specific databases

EchoBASEi EB3317.
EcoGenei EG13547. ivy.

Phylogenomic databases

eggNOGi NOG146309.
HOGENOMi HOG000117011.
OMAi DCAAQNI.
OrthoDBi EOG68H883.

Enzyme and pathway databases

BioCyci EcoCyc:G6104-MONOMER.
ECOL316407:JW0210-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0AD59.
PROi P0AD59.

Gene expression databases

Genevestigatori P0AD59.

Family and domain databases

Gene3Di 3.40.1420.10. 1 hit.
InterProi IPR014453. Ihibitor_vertebrate_lysozyme.
[Graphical view ]
PIRSFi PIRSF009103. Ivy. 1 hit.
SUPFAMi SSF89872. SSF89872. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region."
    Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. Cited for: PROTEIN SEQUENCE OF 29-39.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Small genes/gene-products in Escherichia coli K-12."
    Wasinger V.C., Humphery-Smith I.
    FEMS Microbiol. Lett. 169:375-382(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-38.
    Strain: K12.
  7. "Escherichia coli ykfE ORFan gene encodes a potent inhibitor of C-type lysozyme."
    Montchois V., Abergel C., Sturgis J., Jeudy S., Claverie J.-M.
    J. Biol. Chem. 276:18437-18441(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: K12 / XL1-Blue.
  8. "Crystallization and preliminary crystallographic study of b0220, an 'ORFan' protein of unknown function from Escherichia coli."
    Abergel C., Monchois V., Chenivesse S., Jeudy S., Claverie J.-M.
    Acta Crystallogr. D 56:1694-1695(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CRYSTALLIZATION.
  9. "Structure and evolution of a paradoxical protein family of vertebrate lysozyme inhibitors only found in Gram-negative bacteria."
    Abergel C., Monchois V., Claverie J.-M.
    Submitted (NOV-2001) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

Entry informationi

Entry nameiIVY_ECOLI
AccessioniPrimary (citable) accession number: P0AD59
Secondary accession number(s): P45502, P77185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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