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Protein

Inhibitor of vertebrate lysozyme

Gene

ivy

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Strong inhibitor of lysozyme C.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei88Important for lysozyme inhibition1

GO - Molecular functioni

  • lysozyme inhibitor activity Source: EcoCyc

GO - Biological processi

  • regulation of catalytic activity Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6104-MONOMER.
ECOL316407:JW0210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of vertebrate lysozyme
Gene namesi
Name:ivy
Synonyms:ykfE
Ordered Locus Names:b0220, JW0210
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13547. ivy.

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 282 PublicationsAdd BLAST28
ChainiPRO_000001654629 – 157Inhibitor of vertebrate lysozymeAdd BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 90

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0AD59.
PRIDEiP0AD59.

2D gel databases

SWISS-2DPAGEP0AD59.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi4261212. 10 interactors.
DIPiDIP-10051N.
STRINGi511145.b0220.

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 39Combined sources6
Turni41 – 43Combined sources3
Helixi44 – 51Combined sources8
Helixi59 – 62Combined sources4
Beta strandi65 – 75Combined sources11
Beta strandi77 – 85Combined sources9
Turni90 – 92Combined sources3
Beta strandi93 – 99Combined sources7
Turni101 – 103Combined sources3
Beta strandi106 – 113Combined sources8
Turni115 – 117Combined sources3
Beta strandi120 – 125Combined sources6
Helixi129 – 131Combined sources3
Helixi133 – 144Combined sources12
Helixi146 – 149Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GPQX-ray1.60A/B29-156[»]
1XS0X-ray1.58A/B/C29-156[»]
ProteinModelPortaliP0AD59.
SMRiP0AD59.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AD59.

Family & Domainsi

Sequence similaritiesi

Belongs to the ivy family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108WN0. Bacteria.
ENOG4111K9M. LUCA.
HOGENOMiHOG000117011.
InParanoidiP0AD59.
OMAiDCAAQNI.

Family and domain databases

Gene3Di3.40.1420.10. 1 hit.
InterProiIPR014453. Ihibitor_vertebrate_lysozyme.
[Graphical view]
PIRSFiPIRSF009103. Ivy. 1 hit.
SUPFAMiSSF89872. SSF89872. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AD59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRISSGGMM FKAITTVAAL VIATSAMAQD DLTISSLAKG ETTKAAFNQM
60 70 80 90 100
VQGHKLPAWV MKGGTYTPAQ TVTLGDETYQ VMSACKPHDC GSQRIAVMWS
110 120 130 140 150
EKSNQMTGLF STIDEKTSQE KLTWLNVNDA LSIDGKTVLF AALTGSLENH

PDGFNFK
Length:157
Mass (Da):16,872
Last modified:December 6, 2005 - v1
Checksum:i9156C5944DFE6D84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36Missing AA sequence (PubMed:9868784).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08642.1.
U00096 Genomic DNA. Translation: AAC73324.1.
AP009048 Genomic DNA. Translation: BAA77890.1.
PIRiE64746.
RefSeqiNP_414755.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC73324; AAC73324; b0220.
BAA77890; BAA77890; BAA77890.
GeneIDi946530.
KEGGiecj:JW0210.
eco:b0220.
PATRICi32115555. VBIEscCol129921_0222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08642.1.
U00096 Genomic DNA. Translation: AAC73324.1.
AP009048 Genomic DNA. Translation: BAA77890.1.
PIRiE64746.
RefSeqiNP_414755.1. NC_000913.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GPQX-ray1.60A/B29-156[»]
1XS0X-ray1.58A/B/C29-156[»]
ProteinModelPortaliP0AD59.
SMRiP0AD59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261212. 10 interactors.
DIPiDIP-10051N.
STRINGi511145.b0220.

2D gel databases

SWISS-2DPAGEP0AD59.

Proteomic databases

PaxDbiP0AD59.
PRIDEiP0AD59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73324; AAC73324; b0220.
BAA77890; BAA77890; BAA77890.
GeneIDi946530.
KEGGiecj:JW0210.
eco:b0220.
PATRICi32115555. VBIEscCol129921_0222.

Organism-specific databases

EchoBASEiEB3317.
EcoGeneiEG13547. ivy.

Phylogenomic databases

eggNOGiENOG4108WN0. Bacteria.
ENOG4111K9M. LUCA.
HOGENOMiHOG000117011.
InParanoidiP0AD59.
OMAiDCAAQNI.

Enzyme and pathway databases

BioCyciEcoCyc:G6104-MONOMER.
ECOL316407:JW0210-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AD59.
PROiP0AD59.

Family and domain databases

Gene3Di3.40.1420.10. 1 hit.
InterProiIPR014453. Ihibitor_vertebrate_lysozyme.
[Graphical view]
PIRSFiPIRSF009103. Ivy. 1 hit.
SUPFAMiSSF89872. SSF89872. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIVY_ECOLI
AccessioniPrimary (citable) accession number: P0AD59
Secondary accession number(s): P45502, P77185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.