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Protein

Inner membrane protein YphA

Gene

yphA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:G7337-MONOMER.
ECOL316407:JW2527-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein YphA
Gene namesi
Name:yphA
Ordered Locus Names:b2543, JW2527
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13462. yphA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 5622PeriplasmicSequence analysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Topological domaini78 – 792CytoplasmicSequence analysis
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Topological domaini101 – 11616PeriplasmicSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 1403CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Inner membrane protein YphAPRO_0000169257Add
BLAST

Proteomic databases

PaxDbiP0AD47.

Interactioni

Protein-protein interaction databases

BioGridi4260605. 11 interactions.
STRINGi511145.b2543.

Structurei

3D structure databases

ProteinModelPortaliP0AD47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DoxX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108SB3. Bacteria.
COG2259. LUCA.
HOGENOMiHOG000198398.
InParanoidiP0AD47.
KOiK15977.
OMAiNMVDPER.
PhylomeDBiP0AD47.

Family and domain databases

InterProiIPR032808. DoxX.
[Graphical view]
PfamiPF07681. DoxX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AD47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLRYFDFG AARPVLLLIA RIAVVLIFII FGFPKMMGFD GTVQYMASLG
60 70 80 90 100
APMPMLAAII AVVMEVPAAI LIVLGFFTRP LAVLFIFYTL GTAVIGHHYW
110 120 130 140
DMTGDAVGPN MINFWKNVSI AGAFLLLAIT GPGAISLDRR
Length:140
Mass (Da):15,211
Last modified:November 22, 2005 - v1
Checksum:i99C536AA10AAD2C9
GO

Sequence cautioni

The sequence BAA16446 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA71953 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11070 Genomic DNA. Translation: CAA71953.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75596.2.
AP009048 Genomic DNA. Translation: BAA16446.1. Different initiation.
PIRiF65031.
RefSeqiNP_417038.4. NC_000913.3.
WP_001094726.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75596; AAC75596; b2543.
BAA16446; BAA16446; BAA16446.
GeneIDi947365.
KEGGiecj:JW2527.
eco:b2543.
PATRICi32120483. VBIEscCol129921_2644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11070 Genomic DNA. Translation: CAA71953.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75596.2.
AP009048 Genomic DNA. Translation: BAA16446.1. Different initiation.
PIRiF65031.
RefSeqiNP_417038.4. NC_000913.3.
WP_001094726.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AD47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260605. 11 interactions.
STRINGi511145.b2543.

Proteomic databases

PaxDbiP0AD47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75596; AAC75596; b2543.
BAA16446; BAA16446; BAA16446.
GeneIDi947365.
KEGGiecj:JW2527.
eco:b2543.
PATRICi32120483. VBIEscCol129921_2644.

Organism-specific databases

EchoBASEiEB3235.
EcoGeneiEG13462. yphA.

Phylogenomic databases

eggNOGiENOG4108SB3. Bacteria.
COG2259. LUCA.
HOGENOMiHOG000198398.
InParanoidiP0AD47.
KOiK15977.
OMAiNMVDPER.
PhylomeDBiP0AD47.

Enzyme and pathway databases

BioCyciEcoCyc:G7337-MONOMER.
ECOL316407:JW2527-MONOMER.

Miscellaneous databases

PROiP0AD47.

Family and domain databases

InterProiIPR032808. DoxX.
[Graphical view]
PfamiPF07681. DoxX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPHA_ECOLI
AccessioniPrimary (citable) accession number: P0AD47
Secondary accession number(s): O08101, P77751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.