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Protein

Phosphatidylglycerophosphatase C

Gene

pgpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).1 Publication

Catalytic activityi

Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.1 Publication

Cofactori

Mg2+1 Publication

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgsA)
  2. Phosphatidylglycerophosphatase C (pgpC), Phosphatidylglycerophosphatase A (pgpA), Phosphatidylglycerophosphatase B (pgpB)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphatidylglycerophosphatase activity Source: EcoCyc

GO - Biological processi

  • glycerophospholipid biosynthetic process Source: EcoCyc
  • phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway
  • phospholipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Phospholipid degradation, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11371-MONOMER.
ECOL316407:JW5408-MONOMER.
MetaCyc:EG11371-MONOMER.
UniPathwayiUPA00084; UER00504.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylglycerophosphatase C (EC:3.1.3.27)
Alternative name(s):
Phosphatidylglycerolphosphate phosphatase C
Short name:
PGP phosphatase C
Gene namesi
Name:pgpC
Synonyms:yfhB
Ordered Locus Names:b2560, JW5408
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11371. yfhB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 211PeriplasmicSequence analysisAdd BLAST157

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Simultaneous deletion of pgpC and pgpA increases phosphatidylglycerophosphate (PGP) levels almost hundredfold relative to wild-type. In constrast, simultaneous deletion of pgpC and pgpB leads to a twofold increase of PGP levels. Lethal when combined with deletion of both pgpA and pgpB.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001692471 – 211Phosphatidylglycerophosphatase CAdd BLAST211

Proteomic databases

PaxDbiP0AD42.
PRIDEiP0AD42.

Interactioni

Protein-protein interaction databases

BioGridi4261368. 6 interactors.
STRINGi511145.b2560.

Structurei

3D structure databases

ProteinModelPortaliP0AD42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105HYY. Bacteria.
COG0560. LUCA.
HOGENOMiHOG000219236.
KOiK18697.
OMAiGTFMRYL.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006435. HAD-SF_hydro_IF_YfhB.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01545. YfhB_g-proteo. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AD42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATHERRVVF FDLDGTLHQQ DMFGSFLRYL LRRQPLNALL VLPLLPIIAI
60 70 80 90 100
ALLIKGRAAR WPMSLLLWGC TFGHSEARLQ TLQADFVRWF RDNVTAFPLV
110 120 130 140 150
QERLTTYLLS SDADIWLITG SPQPLVEAVY FDTPWLPRVN LIASQIQRGY
160 170 180 190 200
GGWVLTMRCL GHEKVAQLER KIGTPLRLYS GYSDSNQDNP LLYFCQHRWR
210
VTPRGELQQL E
Length:211
Mass (Da):24,439
Last modified:November 22, 2005 - v1
Checksum:i908E95FE54A3AA2D
GO

Sequence cautioni

The sequence AAA79822 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA10910 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA51063 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72336 Genomic DNA. Translation: CAA51063.1. Different initiation.
D64044 Genomic DNA. Translation: BAA10910.1. Different initiation.
U36841 Genomic DNA. Translation: AAA79822.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75613.2.
AP009048 Genomic DNA. Translation: BAE76736.1.
PIRiS20973.
RefSeqiNP_417055.4. NC_000913.3.
WP_000190655.1. NZ_CP014272.1.

Genome annotation databases

EnsemblBacteriaiAAC75613; AAC75613; b2560.
BAE76736; BAE76736; BAE76736.
GeneIDi947026.
KEGGiecj:JW5408.
eco:b2560.
PATRICi32120519. VBIEscCol129921_2662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72336 Genomic DNA. Translation: CAA51063.1. Different initiation.
D64044 Genomic DNA. Translation: BAA10910.1. Different initiation.
U36841 Genomic DNA. Translation: AAA79822.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75613.2.
AP009048 Genomic DNA. Translation: BAE76736.1.
PIRiS20973.
RefSeqiNP_417055.4. NC_000913.3.
WP_000190655.1. NZ_CP014272.1.

3D structure databases

ProteinModelPortaliP0AD42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261368. 6 interactors.
STRINGi511145.b2560.

Proteomic databases

PaxDbiP0AD42.
PRIDEiP0AD42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75613; AAC75613; b2560.
BAE76736; BAE76736; BAE76736.
GeneIDi947026.
KEGGiecj:JW5408.
eco:b2560.
PATRICi32120519. VBIEscCol129921_2662.

Organism-specific databases

EchoBASEiEB1345.
EcoGeneiEG11371. yfhB.

Phylogenomic databases

eggNOGiENOG4105HYY. Bacteria.
COG0560. LUCA.
HOGENOMiHOG000219236.
KOiK18697.
OMAiGTFMRYL.

Enzyme and pathway databases

UniPathwayiUPA00084; UER00504.
BioCyciEcoCyc:EG11371-MONOMER.
ECOL316407:JW5408-MONOMER.
MetaCyc:EG11371-MONOMER.

Miscellaneous databases

PROiP0AD42.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006435. HAD-SF_hydro_IF_YfhB.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01545. YfhB_g-proteo. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGPC_ECOLI
AccessioniPrimary (citable) accession number: P0AD42
Secondary accession number(s): P30133, Q2MAH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.