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Protein

UPF0721 transmembrane protein YfcA

Gene

yfcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • response to heat Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11144-MONOMER.
ECOL316407:JW2324-MONOMER.
RETL1328306-WGS:GSTH-2510-MONOMER.

Protein family/group databases

TCDBi2.A.102.3.1. the 4-toluene sulfonate uptake permease (tsup) family.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0721 transmembrane protein YfcA
Gene namesi
Name:yfcA
Ordered Locus Names:b2327, JW2324
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11144. yfcA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77PeriplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 302CytoplasmicSequence analysis
Transmembranei31 – 5121HelicalSequence analysisAdd
BLAST
Topological domaini52 – 8433PeriplasmicSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Topological domaini106 – 1116CytoplasmicSequence analysis
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST
Topological domaini133 – 15624PeriplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 19720CytoplasmicSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 26951PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269UPF0721 transmembrane protein YfcAPRO_0000169187Add
BLAST

Proteomic databases

PaxDbiP0AD30.

Interactioni

Protein-protein interaction databases

BioGridi4259583. 16 interactions.
IntActiP0AD30. 2 interactions.
STRINGi511145.b2327.

Structurei

3D structure databases

ProteinModelPortaliP0AD30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0721 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EJ9. Bacteria.
COG0730. LUCA.
HOGENOMiHOG000114880.
InParanoidiP0AD30.
KOiK07090.
OMAiGTNKGQS.
OrthoDBiEOG61VZ6K.
PhylomeDBiP0AD30.

Family and domain databases

InterProiIPR002781. TM_pro_TauE-like.
[Graphical view]
PANTHERiPTHR30269. PTHR30269. 1 hit.
PfamiPF01925. TauE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AD30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METFNSLFMV SPLLLGVLFF VAMLAGFIDS IAGGGGLLTI PALMAAGMSP
60 70 80 90 100
ANALATNKLQ ACGGSISATI YFIRRKVVSL SDQKLNIAMT FVGSMSGALL
110 120 130 140 150
VQYVQADVLR QILPILVICI GLYFLLMPKL GEEDRQRRMY GLPFALIAGG
160 170 180 190 200
CVGFYDGFFG PAAGSFYALA FVTLCGFNLA KATAHAKLLN ATSNIGGLLL
210 220 230 240 250
FILGGKVIWA TGFVMLVGQF LGARMGSRLV LSKGQKLIRP MIVIVSAVMS
260
AKLLYDSHGQ EILHWLGMN
Length:269
Mass (Da):28,643
Last modified:November 22, 2005 - v1
Checksum:iB640B0EBFF1BF7ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16909 mRNA. Translation: CAA34783.1.
U00096 Genomic DNA. Translation: AAC75387.1.
AP009048 Genomic DNA. Translation: BAA16183.1.
PIRiS08346.
RefSeqiNP_416830.1. NC_000913.3.
WP_000447361.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75387; AAC75387; b2327.
BAA16183; BAA16183; BAA16183.
GeneIDi946808.
KEGGiecj:JW2324.
eco:b2327.
PATRICi32120027. VBIEscCol129921_2423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16909 mRNA. Translation: CAA34783.1.
U00096 Genomic DNA. Translation: AAC75387.1.
AP009048 Genomic DNA. Translation: BAA16183.1.
PIRiS08346.
RefSeqiNP_416830.1. NC_000913.3.
WP_000447361.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AD30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259583. 16 interactions.
IntActiP0AD30. 2 interactions.
STRINGi511145.b2327.

Protein family/group databases

TCDBi2.A.102.3.1. the 4-toluene sulfonate uptake permease (tsup) family.

Proteomic databases

PaxDbiP0AD30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75387; AAC75387; b2327.
BAA16183; BAA16183; BAA16183.
GeneIDi946808.
KEGGiecj:JW2324.
eco:b2327.
PATRICi32120027. VBIEscCol129921_2423.

Organism-specific databases

EchoBASEiEB1134.
EcoGeneiEG11144. yfcA.

Phylogenomic databases

eggNOGiENOG4105EJ9. Bacteria.
COG0730. LUCA.
HOGENOMiHOG000114880.
InParanoidiP0AD30.
KOiK07090.
OMAiGTNKGQS.
OrthoDBiEOG61VZ6K.
PhylomeDBiP0AD30.

Enzyme and pathway databases

BioCyciEcoCyc:EG11144-MONOMER.
ECOL316407:JW2324-MONOMER.
RETL1328306-WGS:GSTH-2510-MONOMER.

Miscellaneous databases

PROiP0AD30.

Family and domain databases

InterProiIPR002781. TM_pro_TauE-like.
[Graphical view]
PANTHERiPTHR30269. PTHR30269. 1 hit.
PfamiPF01925. TauE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of mepA, the structural gene of the penicillin-insensitive murein endopeptidase from Escherichia coli."
    Keck W., van Leeuwen A.M., Huber M., Goodell E.W.
    Mol. Microbiol. 4:209-219(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYFCA_ECOLI
AccessioniPrimary (citable) accession number: P0AD30
Secondary accession number(s): P14008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: January 20, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.