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Protein

Transcriptional regulatory protein DcuR

Gene

dcuR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi181 – 200H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoliWiki
  • transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding Source: EcoCyc

GO - Biological processi

  • phosphorelay signal transduction system Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • response to external stimulus Source: InterPro
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciEcoCyc:DCUR-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein DcuR
Gene namesi
Name:dcuR
Synonyms:yjdG
Ordered Locus Names:b4124, JW4085
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12464. dcuR.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810941 – 239Transcriptional regulatory protein DcuRAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated and activated by DcuS.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0AD01.
PRIDEiP0AD01.

PTM databases

iPTMnetiP0AD01.

Interactioni

Protein-protein interaction databases

BioGridi4261980. 12 interactors.
DIPiDIP-48032N.
IntActiP0AD01. 4 interactors.
STRINGi316407.85676876.

Structurei

3D structure databases

ProteinModelPortaliP0AD01.
SMRiP0AD01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST119

Phylogenomic databases

eggNOGiENOG4108MRH. Bacteria.
COG4565. LUCA.
HOGENOMiHOG000034816.
InParanoidiP0AD01.
KOiK07703.
PhylomeDBiP0AD01.

Family and domain databases

CDDicd00156. REC. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR024187. Sig_transdc_resp-reg_cit/mal.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF006171. RR_citrat_malat. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINVLIIDDD AMVAELNRRY VAQIPGFQCC GTASTLEKAK EIIFNSDTPI
60 70 80 90 100
DLILLDIYMQ KENGLDLLPV LHNARCKSDV IVISSAADAA TIKDSLHYGV
110 120 130 140 150
VDYLIKPFQA SRFEEALTGW RQKKMALEKH QYYDQAELDQ LIHGSSSNEQ
160 170 180 190 200
DPRRLPKGLT PQTLRTLCQW IDAHQDYEFS TDELANEVNI SRVSCRKYLI
210 220 230
WLVNCHILFT SIHYGVTGRP VYRYRIQAEH YSLLKQYCQ
Length:239
Mass (Da):27,488
Last modified:November 22, 2005 - v1
Checksum:i4C111A0351F84FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97024.1.
U00096 Genomic DNA. Translation: AAC77085.1.
AP009048 Genomic DNA. Translation: BAE78126.1.
PIRiC65222.
RefSeqiNP_418548.1. NC_000913.3.
WP_000611288.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77085; AAC77085; b4124.
BAE78126; BAE78126; BAE78126.
GeneIDi948640.
KEGGiecj:JW4085.
eco:b4124.
PATRICifig|1411691.4.peg.2576.

Similar proteinsi

Entry informationi

Entry nameiDCUR_ECOLI
AccessioniPrimary (citable) accession number: P0AD01
Secondary accession number(s): P39271, P76794, Q2M6I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 25, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene