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Protein

Transcriptional regulatory protein DcuR

Gene

dcuR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi181 – 200H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoliWiki
  • nucleic acid binding transcription factor activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:DCUR-MONOMER.
ECOL316407:JW4085-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein DcuR
Gene namesi
Name:dcuR
Synonyms:yjdG
Ordered Locus Names:b4124, JW4085
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12464. dcuR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810941 – 239Transcriptional regulatory protein DcuRAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated and activated by DcuS.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0AD01.
PRIDEiP0AD01.

Interactioni

Protein-protein interaction databases

BioGridi4261980. 12 interactors.
DIPiDIP-48032N.
IntActiP0AD01. 4 interactors.
STRINGi511145.b4124.

Structurei

3D structure databases

ProteinModelPortaliP0AD01.
SMRiP0AD01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST119

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108MRH. Bacteria.
COG4565. LUCA.
HOGENOMiHOG000034816.
InParanoidiP0AD01.
KOiK07703.
OMAiICQWIDA.
PhylomeDBiP0AD01.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR024187. Sig_transdc_resp-reg_cit/mal.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF006171. RR_citrat_malat. 1 hit.
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINVLIIDDD AMVAELNRRY VAQIPGFQCC GTASTLEKAK EIIFNSDTPI
60 70 80 90 100
DLILLDIYMQ KENGLDLLPV LHNARCKSDV IVISSAADAA TIKDSLHYGV
110 120 130 140 150
VDYLIKPFQA SRFEEALTGW RQKKMALEKH QYYDQAELDQ LIHGSSSNEQ
160 170 180 190 200
DPRRLPKGLT PQTLRTLCQW IDAHQDYEFS TDELANEVNI SRVSCRKYLI
210 220 230
WLVNCHILFT SIHYGVTGRP VYRYRIQAEH YSLLKQYCQ
Length:239
Mass (Da):27,488
Last modified:November 22, 2005 - v1
Checksum:i4C111A0351F84FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97024.1.
U00096 Genomic DNA. Translation: AAC77085.1.
AP009048 Genomic DNA. Translation: BAE78126.1.
PIRiC65222.
RefSeqiNP_418548.1. NC_000913.3.
WP_000611288.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77085; AAC77085; b4124.
BAE78126; BAE78126; BAE78126.
GeneIDi948640.
KEGGiecj:JW4085.
eco:b4124.
PATRICi32123813. VBIEscCol129921_4255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97024.1.
U00096 Genomic DNA. Translation: AAC77085.1.
AP009048 Genomic DNA. Translation: BAE78126.1.
PIRiC65222.
RefSeqiNP_418548.1. NC_000913.3.
WP_000611288.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AD01.
SMRiP0AD01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261980. 12 interactors.
DIPiDIP-48032N.
IntActiP0AD01. 4 interactors.
STRINGi511145.b4124.

Proteomic databases

PaxDbiP0AD01.
PRIDEiP0AD01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77085; AAC77085; b4124.
BAE78126; BAE78126; BAE78126.
GeneIDi948640.
KEGGiecj:JW4085.
eco:b4124.
PATRICi32123813. VBIEscCol129921_4255.

Organism-specific databases

EchoBASEiEB2357.
EcoGeneiEG12464. dcuR.

Phylogenomic databases

eggNOGiENOG4108MRH. Bacteria.
COG4565. LUCA.
HOGENOMiHOG000034816.
InParanoidiP0AD01.
KOiK07703.
OMAiICQWIDA.
PhylomeDBiP0AD01.

Enzyme and pathway databases

BioCyciEcoCyc:DCUR-MONOMER.
ECOL316407:JW4085-MONOMER.

Miscellaneous databases

PROiP0AD01.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR024187. Sig_transdc_resp-reg_cit/mal.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF006171. RR_citrat_malat. 1 hit.
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCUR_ECOLI
AccessioniPrimary (citable) accession number: P0AD01
Secondary accession number(s): P39271, P76794, Q2M6I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.