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Protein

Transcriptional regulatory protein CusR

Gene

cusR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA and plasmid pRJ1004 gene pcoE in response to increasing levels of copper ions, and probably silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 22399OmpR/PhoB-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • identical protein binding Source: IntAct

GO - Biological processi

  • phosphorelay signal transduction system Source: EcoCyc
  • positive regulation of gene expression Source: EcoCyc
  • regulation of transcription, DNA-templated Source: EcoCyc
  • response to copper ion Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

Copper, DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6319-MONOMER.
ECOL316407:JW0560-MONOMER.
RETL1328306-WGS:GSTH-1298-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein CusR
Gene namesi
Name:cusR
Synonyms:ylcA
Ordered Locus Names:b0571, JW0560
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13851. cusR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Transcriptional regulatory protein CusRPRO_0000081063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 5114-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by CusS.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0ACZ8.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1118807,EBI-1118807

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4259891. 18 interactions.
DIPiDIP-9348N.
IntActiP0ACZ8. 9 interactions.
STRINGi511145.b0571.

Structurei

3D structure databases

ProteinModelPortaliP0ACZ8.
SMRiP0ACZ8. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 116115Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CK6. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
InParanoidiP0ACZ8.
KOiK07665.
OMAiDKVTGFN.
PhylomeDBiP0ACZ8.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR006291. PcoR.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
TIGRFAMsiTIGR01387. cztR_silR_copR. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLIVEDEK KTGEYLTKGL TEAGFVVDLA DNGLNGYHLA MTGDYDLIIL
60 70 80 90 100
DIMLPDVNGW DIVRMLRSAN KGMPILLLTA LGTIEHRVKG LELGADDYLV
110 120 130 140 150
KPFAFAELLA RVRTLLRRGA AVIIESQFQV ADLMVDLVSR KVTRSGTRIT
160 170 180 190 200
LTSKEFTLLE FFLRHQGEVL PRSLIASQVW DMNFDSDTNA IDVAVKRLRG
210 220
KIDNDFEPKL IQTVRGVGYM LEVPDGQ
Length:227
Mass (Da):25,395
Last modified:November 22, 2005 - v1
Checksum:i5CE129597FAE43C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245661 Genomic DNA. Translation: AAF70175.1.
U82598 Genomic DNA. Translation: AAB40769.1.
U00096 Genomic DNA. Translation: AAC73672.1.
AP009048 Genomic DNA. Translation: BAA35205.1.
U82579 Genomic DNA. Translation: AAB41754.1.
PIRiA64790.
RefSeqiNP_415103.1. NC_000913.3.
WP_000770953.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73672; AAC73672; b0571.
BAA35205; BAA35205; BAA35205.
GeneIDi945003.
KEGGiecj:JW0560.
eco:b0571.
PATRICi32116310. VBIEscCol129921_0595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245661 Genomic DNA. Translation: AAF70175.1.
U82598 Genomic DNA. Translation: AAB40769.1.
U00096 Genomic DNA. Translation: AAC73672.1.
AP009048 Genomic DNA. Translation: BAA35205.1.
U82579 Genomic DNA. Translation: AAB41754.1.
PIRiA64790.
RefSeqiNP_415103.1. NC_000913.3.
WP_000770953.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACZ8.
SMRiP0ACZ8. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259891. 18 interactions.
DIPiDIP-9348N.
IntActiP0ACZ8. 9 interactions.
STRINGi511145.b0571.

Proteomic databases

PaxDbiP0ACZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73672; AAC73672; b0571.
BAA35205; BAA35205; BAA35205.
GeneIDi945003.
KEGGiecj:JW0560.
eco:b0571.
PATRICi32116310. VBIEscCol129921_0595.

Organism-specific databases

EchoBASEiEB3612.
EcoGeneiEG13851. cusR.

Phylogenomic databases

eggNOGiENOG4105CK6. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
InParanoidiP0ACZ8.
KOiK07665.
OMAiDKVTGFN.
PhylomeDBiP0ACZ8.

Enzyme and pathway databases

BioCyciEcoCyc:G6319-MONOMER.
ECOL316407:JW0560-MONOMER.
RETL1328306-WGS:GSTH-1298-MONOMER.

Miscellaneous databases

PROiP0ACZ8.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR006291. PcoR.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
TIGRFAMsiTIGR01387. cztR_silR_copR. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUSR_ECOLI
AccessioniPrimary (citable) accession number: P0ACZ8
Secondary accession number(s): P77380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.