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Protein

Positive transcription regulator EvgA

Gene

evgA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi161 – 18020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Positive transcription regulator EvgA
Gene namesi
Name:evgA
Ordered Locus Names:SF2436, S2573
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Positive transcription regulator EvgAPRO_0000081038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 5214-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by EvgS.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0ACZ7.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198214.SF2436.

Structurei

Secondary structure

204
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 66Combined sources
Helixi10 – 2213Combined sources
Beta strandi25 – 328Combined sources
Helixi37 – 448Combined sources
Beta strandi47 – 526Combined sources
Beta strandi56 – 583Combined sources
Helixi60 – 6910Combined sources
Beta strandi74 – 829Combined sources
Helixi87 – 937Combined sources
Beta strandi97 – 1015Combined sources
Helixi102 – 1043Combined sources
Helixi107 – 11711Combined sources
Beta strandi120 – 1245Combined sources
Helixi127 – 1293Combined sources
Beta strandi131 – 1333Combined sources
Helixi135 – 1428Combined sources
Helixi146 – 15510Combined sources
Turni156 – 1583Combined sources
Helixi161 – 1677Combined sources
Helixi172 – 18514Combined sources
Helixi191 – 20010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5F64X-ray2.71A/B/C/D1-204[»]
ProteinModelPortaliP0ACZ7.
SMRiP0ACZ7. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 117116Response regulatoryPROSITE-ProRule annotationAdd
BLAST
Domaini137 – 20266HTH luxR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108WQH. Bacteria.
ENOG4111M1G. LUCA.
HOGENOMiHOG000034813.
KOiK07690.
OMAiHVEKMLD.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIIIDDHP LAIAAIRNLL IKNDIEILAE LTEGGSAVQR VETLKPDIVI
60 70 80 90 100
IDVDIPGVNG IQVLETLRKR QYSGIIIIVS AKNDHFYGKH CADAGANGFV
110 120 130 140 150
SKKEGMNNII AAIEAAKNGY CYFPFSLNRF VGSLTSDQQK LDSLSKQEIS
160 170 180 190 200
VMRYILDGKD NNDIAEKMFI SNKTVSTYKS RLMEKLECKS LMDLYTFAQR

NKIG
Length:204
Mass (Da):22,690
Last modified:November 22, 2005 - v1
Checksum:iE68F932F3729FBBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43947.1.
AE014073 Genomic DNA. Translation: AAP17757.1.
RefSeqiNP_708240.1. NC_004337.2.
WP_000991370.1. NZ_LM651928.1.

Genome annotation databases

EnsemblBacteriaiAAN43947; AAN43947; SF2436.
AAP17757; AAP17757; S2573.
GeneIDi1025897.
KEGGisfl:SF2436.
sfx:S2573.
PATRICi18706749. VBIShiFle31049_2849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43947.1.
AE014073 Genomic DNA. Translation: AAP17757.1.
RefSeqiNP_708240.1. NC_004337.2.
WP_000991370.1. NZ_LM651928.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5F64X-ray2.71A/B/C/D1-204[»]
ProteinModelPortaliP0ACZ7.
SMRiP0ACZ7. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF2436.

Proteomic databases

PaxDbiP0ACZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN43947; AAN43947; SF2436.
AAP17757; AAP17757; S2573.
GeneIDi1025897.
KEGGisfl:SF2436.
sfx:S2573.
PATRICi18706749. VBIShiFle31049_2849.

Phylogenomic databases

eggNOGiENOG4108WQH. Bacteria.
ENOG4111M1G. LUCA.
HOGENOMiHOG000034813.
KOiK07690.
OMAiHVEKMLD.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiEVGA_SHIFL
AccessioniPrimary (citable) accession number: P0ACZ7
Secondary accession number(s): P30854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 16, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.