Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Positive transcription regulator EvgA

Gene

evgA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi161 – 180H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Positive transcription regulator EvgA
Gene namesi
Name:evgA
Ordered Locus Names:SF2436, S2573
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810381 – 204Positive transcription regulator EvgAAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei524-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by EvgS.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0ACZ7.
PRIDEiP0ACZ7.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198214.SF2436.

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 6Combined sources6
Helixi10 – 22Combined sources13
Beta strandi25 – 32Combined sources8
Helixi37 – 44Combined sources8
Beta strandi47 – 52Combined sources6
Beta strandi56 – 58Combined sources3
Helixi60 – 69Combined sources10
Beta strandi74 – 82Combined sources9
Helixi87 – 93Combined sources7
Beta strandi97 – 101Combined sources5
Helixi102 – 104Combined sources3
Helixi107 – 117Combined sources11
Beta strandi120 – 124Combined sources5
Helixi127 – 129Combined sources3
Beta strandi131 – 133Combined sources3
Helixi135 – 142Combined sources8
Helixi146 – 155Combined sources10
Turni156 – 158Combined sources3
Helixi161 – 167Combined sources7
Helixi172 – 185Combined sources14
Helixi191 – 200Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F64X-ray2.71A/B/C/D1-204[»]
ProteinModelPortaliP0ACZ7.
SMRiP0ACZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 117Response regulatoryPROSITE-ProRule annotationAdd BLAST116
Domaini137 – 202HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108WQH. Bacteria.
ENOG4111M1G. LUCA.
HOGENOMiHOG000034813.
KOiK07690.
OMAiPNTIKTH.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIIIDDHP LAIAAIRNLL IKNDIEILAE LTEGGSAVQR VETLKPDIVI
60 70 80 90 100
IDVDIPGVNG IQVLETLRKR QYSGIIIIVS AKNDHFYGKH CADAGANGFV
110 120 130 140 150
SKKEGMNNII AAIEAAKNGY CYFPFSLNRF VGSLTSDQQK LDSLSKQEIS
160 170 180 190 200
VMRYILDGKD NNDIAEKMFI SNKTVSTYKS RLMEKLECKS LMDLYTFAQR

NKIG
Length:204
Mass (Da):22,690
Last modified:November 22, 2005 - v1
Checksum:iE68F932F3729FBBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43947.1.
AE014073 Genomic DNA. Translation: AAP17757.1.
RefSeqiNP_708240.1. NC_004337.2.
WP_000991370.1. NZ_LVJC01000001.1.

Genome annotation databases

EnsemblBacteriaiAAN43947; AAN43947; SF2436.
AAP17757; AAP17757; S2573.
GeneIDi1025897.
KEGGisfl:SF2436.
sft:NCTC1_02672.
sfx:S2573.
PATRICi18706749. VBIShiFle31049_2849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43947.1.
AE014073 Genomic DNA. Translation: AAP17757.1.
RefSeqiNP_708240.1. NC_004337.2.
WP_000991370.1. NZ_LVJC01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F64X-ray2.71A/B/C/D1-204[»]
ProteinModelPortaliP0ACZ7.
SMRiP0ACZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF2436.

Proteomic databases

PaxDbiP0ACZ7.
PRIDEiP0ACZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN43947; AAN43947; SF2436.
AAP17757; AAP17757; S2573.
GeneIDi1025897.
KEGGisfl:SF2436.
sft:NCTC1_02672.
sfx:S2573.
PATRICi18706749. VBIShiFle31049_2849.

Phylogenomic databases

eggNOGiENOG4108WQH. Bacteria.
ENOG4111M1G. LUCA.
HOGENOMiHOG000034813.
KOiK07690.
OMAiPNTIKTH.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEVGA_SHIFL
AccessioniPrimary (citable) accession number: P0ACZ7
Secondary accession number(s): P30854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.