P0ACZ3 (ETP_ECO57) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight protein-tyrosine-phosphatase etp
EC=3.1.3.48

Gene names

Name:	etp
Ordered Locus Names:	Z1399, ECs1138

Organism

Escherichia coli O157:H7 [Complete proteome] [HAMAP]

Taxonomic identifier

83334 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Dephosphorylates etk By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Sequence caution	The sequence AAG55530.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB34561.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	Low molecular weight protein-tyrosine-phosphatase etp		PRO_0000046577
Sites
	Active site	13	1	Nucleophile By similarity
	Active site	18	1	By similarity
	Active site	119	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0ACZ3 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 136DA7AEF6AE8F0C	FASTA	148	16,386
	10 20 30 40 50 60 MAQLKFNSIL VVCTGNICRS PIGERLLRKR LPGVKVKSAG VHGLVKHPAD ATAADVAANH 70 80 90 100 110 120 GVSLEGHAGR KLTAEMARNY DLILAMESEH IAQVTAIAPE VRGKTMLFGQ WLEQKEIPDP 130 140 YRKSQDAFEH VYGMLERASQ EWAKRLSR

References

[1]

"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R. Nature 409:529-533(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.

[2]

"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. , Kuhara S., Shiba T., Hattori M., Shinagawa H. DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005174 Genomic DNA. Translation: AAG55530.1. Different initiation. BA000007 Genomic DNA. Translation: BAB34561.1. Different initiation.
RefSeq	NP_286919.2. NC_002655.2. NP_309165.2. NC_002695.1.
3D structure databases
ProteinModelPortal	P0ACZ3.
SMR	P0ACZ3. Positions 4-146.
ModBase	Search...
Protein-protein interaction databases
STRING	155864.Z1399.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAG55530; AAG55530; Z1399. BAB34561; BAB34561; BAB34561.
GeneID	914076. 959046.
KEGG	ece:Z1399. ecs:ECs1138.
PATRIC	18351537. VBIEscCol44059_5347.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0394.
HOGENOM	HOG000273091.
KO	K01104.
OMA	VMEKKHI.
ProtClustDB	PRK11391.
Enzyme and pathway databases
BioCyc	ECOL386585:GJFA-1131-MONOMER.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ETP_ECO57

Accession

Primary (citable) accession number: P0ACZ3
Secondary accession number(s): P75880, Q8XC24

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program