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Protein

Low molecular weight protein-tyrosine-phosphatase Etp

Gene

etp

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Dephosphorylates etk.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131NucleophileBy similarity
Active sitei18 – 181By similarity
Active sitei119 – 1191Proton donorBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-1131-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase Etp (EC:3.1.3.48)
Gene namesi
Name:etp
Ordered Locus Names:Z1399, ECs1138
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558 Componenti: Chromosome UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Low molecular weight protein-tyrosine-phosphatase EtpPRO_0000046577Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z1399.

Structurei

3D structure databases

ProteinModelPortaliP0ACZ3.
SMRiP0ACZ3. Positions 4-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273091.
KOiK01104.
OMAiLCVGNIC.
OrthoDBiEOG63VC26.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLKFNSIL VVCTGNICRS PIGERLLRKR LPGVKVKSAG VHGLVKHPAD
60 70 80 90 100
ATAADVAANH GVSLEGHAGR KLTAEMARNY DLILAMESEH IAQVTAIAPE
110 120 130 140
VRGKTMLFGQ WLEQKEIPDP YRKSQDAFEH VYGMLERASQ EWAKRLSR
Length:148
Mass (Da):16,386
Last modified:November 22, 2005 - v1
Checksum:i136DA7AEF6AE8F0C
GO

Sequence cautioni

The sequence AAG55530.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB34561.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55530.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB34561.1. Different initiation.
RefSeqiNP_286919.2. NC_002655.2.
NP_309165.2. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG55530; AAG55530; Z1399.
BAB34561; BAB34561; BAB34561.
GeneIDi914076.
959046.
KEGGiece:Z1399.
ecs:ECs1138.
PATRICi18351537. VBIEscCol44059_5347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55530.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB34561.1. Different initiation.
RefSeqiNP_286919.2. NC_002655.2.
NP_309165.2. NC_002695.1.

3D structure databases

ProteinModelPortaliP0ACZ3.
SMRiP0ACZ3. Positions 4-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z1399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG55530; AAG55530; Z1399.
BAB34561; BAB34561; BAB34561.
GeneIDi914076.
959046.
KEGGiece:Z1399.
ecs:ECs1138.
PATRICi18351537. VBIEscCol44059_5347.

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273091.
KOiK01104.
OMAiLCVGNIC.
OrthoDBiEOG63VC26.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-1131-MONOMER.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiETP_ECO57
AccessioniPrimary (citable) accession number: P0ACZ3
Secondary accession number(s): P75880, Q8XC24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 4, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.