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P0ACZ2

- ETP_ECOLI

UniProt

P0ACZ2 - ETP_ECOLI

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Protein

Low molecular weight protein-tyrosine-phosphatase etp

Gene

etp

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Dephosphorylates etk.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131NucleophileBy similarity
Active sitei18 – 181By similarity
Active sitei119 – 1191Proton donorBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: EcoCyc

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciEcoCyc:G6503-MONOMER.
ECOL316407:JW5132-MONOMER.
MetaCyc:G6503-MONOMER.

Protein family/group databases

PptaseDBiP3D0412163.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase etp (EC:3.1.3.48)
Gene namesi
Name:etp
Synonyms:yccY
Ordered Locus Names:b0982, JW5132
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13727. etp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Low molecular weight protein-tyrosine-phosphatase etpPRO_0000046576Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP0ACZ2.

Interactioni

Protein-protein interaction databases

STRINGi511145.b0982.

Structurei

3D structure databases

ProteinModelPortaliP0ACZ2.
SMRiP0ACZ2. Positions 4-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273091.
InParanoidiP0ACZ2.
KOiK01104.
OMAiHAYQLID.
OrthoDBiEOG63VC26.
PhylomeDBiP0ACZ2.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACZ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLKFNSIL VVCTGNICRS PIGERLLRKR LPGVKVKSAG VHGLVKHPAD
60 70 80 90 100
ATAADVAANH GVSLEGHAGR KLTAEMARNY DLILAMESEH IAQVTAIAPE
110 120 130 140
VRGKTMLFGQ WLEQKEIPDP YRKSQDAFEH VYGMLERASQ EWAKRLSR
Length:148
Mass (Da):16,386
Last modified:November 22, 2005 - v1
Checksum:i136DA7AEF6AE8F0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74067.2.
AP009048 Genomic DNA. Translation: BAA35747.2.
PIRiD64839.
RefSeqiNP_415502.4. NC_000913.3.
YP_489253.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74067; AAC74067; b0982.
BAA35747; BAA35747; BAA35747.
GeneIDi12932413.
945236.
KEGGiecj:Y75_p0953.
eco:b0982.
PATRICi32117187. VBIEscCol129921_1017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74067.2 .
AP009048 Genomic DNA. Translation: BAA35747.2 .
PIRi D64839.
RefSeqi NP_415502.4. NC_000913.3.
YP_489253.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0ACZ2.
SMRi P0ACZ2. Positions 4-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 511145.b0982.

Protein family/group databases

PptaseDBi P3D0412163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74067 ; AAC74067 ; b0982 .
BAA35747 ; BAA35747 ; BAA35747 .
GeneIDi 12932413.
945236.
KEGGi ecj:Y75_p0953.
eco:b0982.
PATRICi 32117187. VBIEscCol129921_1017.

Organism-specific databases

EchoBASEi EB3491.
EcoGenei EG13727. etp.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273091.
InParanoidi P0ACZ2.
KOi K01104.
OMAi HAYQLID.
OrthoDBi EOG63VC26.
PhylomeDBi P0ACZ2.

Enzyme and pathway databases

BioCyci EcoCyc:G6503-MONOMER.
ECOL316407:JW5132-MONOMER.
MetaCyc:G6503-MONOMER.

Miscellaneous databases

PROi P0ACZ2.

Gene expression databases

Genevestigatori P0ACZ2.

Family and domain databases

InterProi IPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717:SF7. PTHR11717:SF7. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
PRINTSi PR00719. LMWPTPASE.
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in Gram-negative bacteria."
    Vincent C., Duclos B., Grangeasse C., Vaganay E., Riberty M., Cozzone A.J., Doublet P.
    J. Mol. Biol. 304:311-321(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: K12 / JM109 / ATCC 53323.

Entry informationi

Entry nameiETP_ECOLI
AccessioniPrimary (citable) accession number: P0ACZ2
Secondary accession number(s): P75880, Q8XC24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3