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P0ACZ2

- ETP_ECOLI

UniProt

P0ACZ2 - ETP_ECOLI

Protein

Low molecular weight protein-tyrosine-phosphatase etp

Gene

etp

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Dephosphorylates etk.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei13 – 131NucleophileBy similarity
    Active sitei18 – 181By similarity
    Active sitei119 – 1191Proton donorBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: EcoCyc

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: EcoCyc

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BioCyciEcoCyc:G6503-MONOMER.
    ECOL316407:JW5132-MONOMER.
    MetaCyc:G6503-MONOMER.

    Protein family/group databases

    PptaseDBiP3D0412163.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low molecular weight protein-tyrosine-phosphatase etp (EC:3.1.3.48)
    Gene namesi
    Name:etp
    Synonyms:yccY
    Ordered Locus Names:b0982, JW5132
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13727. etp.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 148148Low molecular weight protein-tyrosine-phosphatase etpPRO_0000046576Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP0ACZ2.

    Interactioni

    Protein-protein interaction databases

    STRINGi511145.b0982.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ACZ2.
    SMRiP0ACZ2. Positions 4-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273091.
    KOiK01104.
    OMAiHAYQLID.
    OrthoDBiEOG63VC26.
    PhylomeDBiP0ACZ2.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    PRINTSiPR00719. LMWPTPASE.
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0ACZ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLKFNSIL VVCTGNICRS PIGERLLRKR LPGVKVKSAG VHGLVKHPAD    50
    ATAADVAANH GVSLEGHAGR KLTAEMARNY DLILAMESEH IAQVTAIAPE 100
    VRGKTMLFGQ WLEQKEIPDP YRKSQDAFEH VYGMLERASQ EWAKRLSR 148
    Length:148
    Mass (Da):16,386
    Last modified:November 22, 2005 - v1
    Checksum:i136DA7AEF6AE8F0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC74067.2.
    AP009048 Genomic DNA. Translation: BAA35747.2.
    PIRiD64839.
    RefSeqiNP_415502.4. NC_000913.3.
    YP_489253.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74067; AAC74067; b0982.
    BAA35747; BAA35747; BAA35747.
    GeneIDi12932413.
    945236.
    KEGGiecj:Y75_p0953.
    eco:b0982.
    PATRICi32117187. VBIEscCol129921_1017.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC74067.2 .
    AP009048 Genomic DNA. Translation: BAA35747.2 .
    PIRi D64839.
    RefSeqi NP_415502.4. NC_000913.3.
    YP_489253.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0ACZ2.
    SMRi P0ACZ2. Positions 4-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 511145.b0982.

    Protein family/group databases

    PptaseDBi P3D0412163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74067 ; AAC74067 ; b0982 .
    BAA35747 ; BAA35747 ; BAA35747 .
    GeneIDi 12932413.
    945236.
    KEGGi ecj:Y75_p0953.
    eco:b0982.
    PATRICi 32117187. VBIEscCol129921_1017.

    Organism-specific databases

    EchoBASEi EB3491.
    EcoGenei EG13727. etp.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273091.
    KOi K01104.
    OMAi HAYQLID.
    OrthoDBi EOG63VC26.
    PhylomeDBi P0ACZ2.

    Enzyme and pathway databases

    BioCyci EcoCyc:G6503-MONOMER.
    ECOL316407:JW5132-MONOMER.
    MetaCyc:G6503-MONOMER.

    Miscellaneous databases

    PROi P0ACZ2.

    Gene expression databases

    Genevestigatori P0ACZ2.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    PRINTSi PR00719. LMWPTPASE.
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in Gram-negative bacteria."
      Vincent C., Duclos B., Grangeasse C., Vaganay E., Riberty M., Cozzone A.J., Doublet P.
      J. Mol. Biol. 304:311-321(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Strain: K12 / JM109 / ATCC 53323.

    Entry informationi

    Entry nameiETP_ECOLI
    AccessioniPrimary (citable) accession number: P0ACZ2
    Secondary accession number(s): P75880, Q8XC24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3