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P0ACZ2 (ETP_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight protein-tyrosine-phosphatase etp

EC=3.1.3.48
Gene names
Name:etp
Synonyms:yccY
Ordered Locus Names:b0982, JW5132
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Dephosphorylates etk.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Caution

In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 148148Low molecular weight protein-tyrosine-phosphatase etp
PRO_0000046576

Sites

Active site131Nucleophile By similarity
Active site181 By similarity
Active site1191Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P0ACZ2 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 136DA7AEF6AE8F0C

FASTA14816,386
        10         20         30         40         50         60 
MAQLKFNSIL VVCTGNICRS PIGERLLRKR LPGVKVKSAG VHGLVKHPAD ATAADVAANH 

        70         80         90        100        110        120 
GVSLEGHAGR KLTAEMARNY DLILAMESEH IAQVTAIAPE VRGKTMLFGQ WLEQKEIPDP 

       130        140 
YRKSQDAFEH VYGMLERASQ EWAKRLSR 

« Hide

References

« Hide 'large scale' references
[1]"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map."
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. expand/collapse author list , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T.
DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in Gram-negative bacteria."
Vincent C., Duclos B., Grangeasse C., Vaganay E., Riberty M., Cozzone A.J., Doublet P.
J. Mol. Biol. 304:311-321(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Strain: K12 / JM109 / ATCC 53323.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00096 Genomic DNA. Translation: AAC74067.2.
AP009048 Genomic DNA. Translation: BAA35747.2.
PIRD64839.
RefSeqNP_415502.4. NC_000913.3.
YP_489253.1. NC_007779.1.

3D structure databases

ProteinModelPortalP0ACZ2.
SMRP0ACZ2. Positions 4-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING511145.b0982.

Protein family/group databases

PptaseDBP3D0412163.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74067; AAC74067; b0982.
BAA35747; BAA35747; BAA35747.
GeneID12932413.
945236.
KEGGecj:Y75_p0953.
eco:b0982.
PATRIC32117187. VBIEscCol129921_1017.

Organism-specific databases

EchoBASEEB3491.
EcoGeneEG13727. etp.

Phylogenomic databases

eggNOGCOG0394.
HOGENOMHOG000273091.
KOK01104.
OMAHAYQLID.
OrthoDBEOG63VC26.
PhylomeDBP0ACZ2.

Enzyme and pathway databases

BioCycEcoCyc:G6503-MONOMER.
ECOL316407:JW5132-MONOMER.
MetaCyc:G6503-MONOMER.

Gene expression databases

GenevestigatorP0ACZ2.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Other

PROP0ACZ2.

Entry information

Entry nameETP_ECOLI
AccessionPrimary (citable) accession number: P0ACZ2
Secondary accession number(s): P75880, Q8XC24
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene