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Protein

Low molecular weight protein-tyrosine-phosphatase Etp

Gene

etp

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates etk.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13NucleophileBy similarity1
Active sitei18By similarity1
Active sitei119Proton donorBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: EcoCyc

GO - Biological processi

  • peptidyl-tyrosine dephosphorylation Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciEcoCyc:G6503-MONOMER.
ECOL316407:JW5132-MONOMER.
MetaCyc:G6503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase Etp (EC:3.1.3.48)
Gene namesi
Name:etp
Synonyms:yccY
Ordered Locus Names:b0982, JW5132
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13727. etp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465761 – 148Low molecular weight protein-tyrosine-phosphatase EtpAdd BLAST148

Proteomic databases

PaxDbiP0ACZ2.
PRIDEiP0ACZ2.

Interactioni

Protein-protein interaction databases

BioGridi4261407. 377 interactors.
STRINGi511145.b0982.

Structurei

3D structure databases

ProteinModelPortaliP0ACZ2.
SMRiP0ACZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107ZF2. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273091.
InParanoidiP0ACZ2.
KOiK01104.
OMAiLCVGNIC.
PhylomeDBiP0ACZ2.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF20. PTHR11717:SF20. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLKFNSIL VVCTGNICRS PIGERLLRKR LPGVKVKSAG VHGLVKHPAD
60 70 80 90 100
ATAADVAANH GVSLEGHAGR KLTAEMARNY DLILAMESEH IAQVTAIAPE
110 120 130 140
VRGKTMLFGQ WLEQKEIPDP YRKSQDAFEH VYGMLERASQ EWAKRLSR
Length:148
Mass (Da):16,386
Last modified:November 22, 2005 - v1
Checksum:i136DA7AEF6AE8F0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74067.2.
AP009048 Genomic DNA. Translation: BAA35747.2.
PIRiD64839.
RefSeqiNP_415502.4. NC_000913.3.
WP_000057871.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74067; AAC74067; b0982.
BAA35747; BAA35747; BAA35747.
GeneIDi945236.
KEGGiecj:JW5132.
eco:b0982.
PATRICi32117187. VBIEscCol129921_1017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74067.2.
AP009048 Genomic DNA. Translation: BAA35747.2.
PIRiD64839.
RefSeqiNP_415502.4. NC_000913.3.
WP_000057871.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACZ2.
SMRiP0ACZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261407. 377 interactors.
STRINGi511145.b0982.

Proteomic databases

PaxDbiP0ACZ2.
PRIDEiP0ACZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74067; AAC74067; b0982.
BAA35747; BAA35747; BAA35747.
GeneIDi945236.
KEGGiecj:JW5132.
eco:b0982.
PATRICi32117187. VBIEscCol129921_1017.

Organism-specific databases

EchoBASEiEB3491.
EcoGeneiEG13727. etp.

Phylogenomic databases

eggNOGiENOG4107ZF2. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273091.
InParanoidiP0ACZ2.
KOiK01104.
OMAiLCVGNIC.
PhylomeDBiP0ACZ2.

Enzyme and pathway databases

BioCyciEcoCyc:G6503-MONOMER.
ECOL316407:JW5132-MONOMER.
MetaCyc:G6503-MONOMER.

Miscellaneous databases

PROiP0ACZ2.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF20. PTHR11717:SF20. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiETP_ECOLI
AccessioniPrimary (citable) accession number: P0ACZ2
Secondary accession number(s): P75880, Q8XC24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.