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Protein

Putative NAD(P)H nitroreductase YdjA

Gene

ydjA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

FMN1 PublicationNote: Binds 1 FMN per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351FMN; shared with dimeric partner1 Publication
Binding sitei39 – 391FMN; shared with dimeric partner1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 123FMN1 Publication
Nucleotide bindingi121 – 1266NAD or NADPSequence analysis
Nucleotide bindingi131 – 1333FMN1 Publication

GO - Molecular functioni

  • FMN binding Source: EcoCyc
  • oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NAD, NADP

Enzyme and pathway databases

BioCyciEcoCyc:EG11134-MONOMER.
ECOL316407:JW1754-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative NAD(P)H nitroreductase YdjA (EC:1.-.-.-)
Gene namesi
Name:ydjA
Ordered Locus Names:b1765, JW1754
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11134. ydjA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Putative NAD(P)H nitroreductase YdjAPRO_0000169002Add
BLAST

Proteomic databases

EPDiP0ACY1.
PaxDbiP0ACY1.
PRIDEiP0ACY1.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4259139. 160 interactions.
DIPiDIP-31841N.
IntActiP0ACY1. 11 interactions.
MINTiMINT-1239401.
STRINGi511145.b1765.

Structurei

Secondary structure

1
183
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 97Combined sources
Beta strandi16 – 183Combined sources
Helixi23 – 3311Combined sources
Beta strandi46 – 516Combined sources
Helixi53 – 6917Combined sources
Helixi73 – 819Combined sources
Helixi82 – 854Combined sources
Beta strandi86 – 949Combined sources
Beta strandi100 – 1023Combined sources
Helixi104 – 12320Combined sources
Turni124 – 1263Combined sources
Beta strandi128 – 1325Combined sources
Helixi135 – 1384Combined sources
Helixi140 – 1456Combined sources
Beta strandi153 – 16311Combined sources
Helixi177 – 1793Combined sources
Beta strandi180 – 1823Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BM1X-ray2.00A/B1-183[»]
3BM2X-ray2.10A/B1-183[»]
ProteinModelPortaliP0ACY1.
SMRiP0ACY1. Positions 1-183.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACY1.

Family & Domainsi

Sequence similaritiesi

Belongs to the nitroreductase family.Curated

Phylogenomic databases

eggNOGiENOG41069NU. Bacteria.
COG0778. LUCA.
HOGENOMiHOG000146733.
InParanoidiP0ACY1.
OMAiQGIGAVW.
PhylomeDBiP0ACY1.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
IPR026021. YdjA-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
PIRSFiPIRSF000232. YdjA. 1 hit.
SUPFAMiSSF55469. SSF55469. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALELLINR RSASRLAEPA PTGEQLQNIL RAGMRAPDHK SMQPWHFFVI
60 70 80 90 100
EGEGRERFSA VLEQGAIAAG SDDKAIDKAR NAPFRAPLII TVVAKCEENH
110 120 130 140 150
KVPRWEQEMS AGCAVMAMQM AAVAQGFGGI WRSGALTESP VVREAFGCRE
160 170 180
QDKIVGFLYL GTPQLKASTS INVPDPTPFV TYF
Length:183
Mass (Da):20,059
Last modified:November 22, 2005 - v1
Checksum:iA69809EE378847CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68961 Genomic DNA. Translation: AAA24245.1.
U00096 Genomic DNA. Translation: AAC74835.1.
AP009048 Genomic DNA. Translation: BAA15556.1.
PIRiA40360.
RefSeqiNP_416279.1. NC_000913.3.
WP_000339283.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74835; AAC74835; b1765.
BAA15556; BAA15556; BAA15556.
GeneIDi945964.
KEGGiecj:JW1754.
eco:b1765.
PATRICi32118841. VBIEscCol129921_1838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68961 Genomic DNA. Translation: AAA24245.1.
U00096 Genomic DNA. Translation: AAC74835.1.
AP009048 Genomic DNA. Translation: BAA15556.1.
PIRiA40360.
RefSeqiNP_416279.1. NC_000913.3.
WP_000339283.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BM1X-ray2.00A/B1-183[»]
3BM2X-ray2.10A/B1-183[»]
ProteinModelPortaliP0ACY1.
SMRiP0ACY1. Positions 1-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259139. 160 interactions.
DIPiDIP-31841N.
IntActiP0ACY1. 11 interactions.
MINTiMINT-1239401.
STRINGi511145.b1765.

Proteomic databases

EPDiP0ACY1.
PaxDbiP0ACY1.
PRIDEiP0ACY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74835; AAC74835; b1765.
BAA15556; BAA15556; BAA15556.
GeneIDi945964.
KEGGiecj:JW1754.
eco:b1765.
PATRICi32118841. VBIEscCol129921_1838.

Organism-specific databases

EchoBASEiEB1124.
EcoGeneiEG11134. ydjA.

Phylogenomic databases

eggNOGiENOG41069NU. Bacteria.
COG0778. LUCA.
HOGENOMiHOG000146733.
InParanoidiP0ACY1.
OMAiQGIGAVW.
PhylomeDBiP0ACY1.

Enzyme and pathway databases

BioCyciEcoCyc:EG11134-MONOMER.
ECOL316407:JW1754-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ACY1.
PROiP0ACY1.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
IPR026021. YdjA-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
PIRSFiPIRSF000232. YdjA. 1 hit.
SUPFAMiSSF55469. SSF55469. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYDJA_ECOLI
AccessioniPrimary (citable) accession number: P0ACY1
Secondary accession number(s): P24250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.