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Protein

Fumarase D

Gene

fumD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as subsrate.1 Publication

Catalytic activityi

(S)-malate = fumarate + H2O.1 Publication

GO - Molecular functioni

  • fumarate hydratase activity Source: EcoCyc

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciEcoCyc:G6903-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarase D1 Publication (EC:4.2.1.21 Publication)
Gene namesi
Name:fumD1 Publication
Synonyms:ydhZImported
Ordered Locus Names:b1675, JW1665
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13960. ydhZ.

Pathology & Biotechi

Disruption phenotypei

Cells grow to slightly higher density than wild-type in sublethal levels of streptomycin (PubMed:25316676).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001689821 – 69Fumarase DAdd BLAST69

Proteomic databases

PaxDbiP0ACX5.
PRIDEiP0ACX5.

Interactioni

Protein-protein interaction databases

BioGridi4259670. 4 interactors.
IntActiP0ACX5. 10 interactors.

Structurei

3D structure databases

ProteinModelPortaliP0ACX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FumD family.Curated

Phylogenomic databases

eggNOGiENOG4105RFR. Bacteria.
ENOG4111YPS. LUCA.
HOGENOMiHOG000267905.

Family and domain databases

InterProiView protein in InterPro
IPR024493. FumD.
PfamiView protein in Pfam
PF10965. DUF2767. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNRTKEDEL YREMCRVVGK VVLEMRDLGQ EPKHIVIAGV LRTALANKRI
60
QRSELEKQAM ETVINALVK
Length:69
Mass (Da):7,907
Last modified:November 22, 2005 - v1
Checksum:iA98BDA2AADEF5C32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68703 Genomic DNA. Translation: AAB47951.1.
U00096 Genomic DNA. Translation: AAC74745.1.
AP009048 Genomic DNA. Translation: BAE76499.1.
PIRiC64925.
RefSeqiNP_416190.1. NC_000913.3.
WP_000528342.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74745; AAC74745; b1675.
BAE76499; BAE76499; BAE76499.
GeneIDi946180.
KEGGiecj:JW1665.
eco:b1675.
PATRICifig|511145.12.peg.1746.

Similar proteinsi

Entry informationi

Entry nameiFUMD_ECOLI
AccessioniPrimary (citable) accession number: P0ACX5
Secondary accession number(s): P77274, Q2MB57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: August 30, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families