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Protein

Fumarase D

Gene

fumD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as subsrate.1 Publication

Catalytic activityi

(S)-malate = fumarate + H2O.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciEcoCyc:G6903-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarase D1 Publication (EC:4.2.1.21 Publication)
Gene namesi
Name:fumD1 Publication
Synonyms:ydhZImported
Ordered Locus Names:b1675, JW1665
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13960. ydhZ.

Pathology & Biotechi

Disruption phenotypei

Cells grow to slightly higher density than wild-type in sublethal levels of streptomycin (PubMed:25316676).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001689821 – 69Fumarase DAdd BLAST69

Proteomic databases

PaxDbiP0ACX5.
PRIDEiP0ACX5.

Interactioni

Protein-protein interaction databases

BioGridi4259670. 4 interactors.
IntActiP0ACX5. 10 interactors.
STRINGi511145.b1675.

Structurei

3D structure databases

ProteinModelPortaliP0ACX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FumD family.Curated

Phylogenomic databases

eggNOGiENOG4105RFR. Bacteria.
ENOG4111YPS. LUCA.
HOGENOMiHOG000267905.

Family and domain databases

InterProiView protein in InterPro
IPR024493. FumD.
PfamiView protein in Pfam
PF10965. DUF2767. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNRTKEDEL YREMCRVVGK VVLEMRDLGQ EPKHIVIAGV LRTALANKRI
60
QRSELEKQAM ETVINALVK
Length:69
Mass (Da):7,907
Last modified:November 22, 2005 - v1
Checksum:iA98BDA2AADEF5C32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68703 Genomic DNA. Translation: AAB47951.1.
U00096 Genomic DNA. Translation: AAC74745.1.
AP009048 Genomic DNA. Translation: BAE76499.1.
PIRiC64925.
RefSeqiNP_416190.1. NC_000913.3.
WP_000528342.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74745; AAC74745; b1675.
BAE76499; BAE76499; BAE76499.
GeneIDi946180.
KEGGiecj:JW1665.
eco:b1675.
PATRICifig|511145.12.peg.1746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68703 Genomic DNA. Translation: AAB47951.1.
U00096 Genomic DNA. Translation: AAC74745.1.
AP009048 Genomic DNA. Translation: BAE76499.1.
PIRiC64925.
RefSeqiNP_416190.1. NC_000913.3.
WP_000528342.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259670. 4 interactors.
IntActiP0ACX5. 10 interactors.
STRINGi511145.b1675.

Proteomic databases

PaxDbiP0ACX5.
PRIDEiP0ACX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74745; AAC74745; b1675.
BAE76499; BAE76499; BAE76499.
GeneIDi946180.
KEGGiecj:JW1665.
eco:b1675.
PATRICifig|511145.12.peg.1746.

Organism-specific databases

EchoBASEiEB3718.
EcoGeneiEG13960. ydhZ.

Phylogenomic databases

eggNOGiENOG4105RFR. Bacteria.
ENOG4111YPS. LUCA.
HOGENOMiHOG000267905.

Enzyme and pathway databases

BioCyciEcoCyc:G6903-MONOMER.

Miscellaneous databases

PROiPR:P0ACX5.

Family and domain databases

InterProiView protein in InterPro
IPR024493. FumD.
PfamiView protein in Pfam
PF10965. DUF2767. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUMD_ECOLI
AccessioniPrimary (citable) accession number: P0ACX5
Secondary accession number(s): P77274, Q2MB57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.