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Protein

Lipopolysaccharide assembly protein A

Gene

lapA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the assembly of lipopolysaccharide (LPS).UniRule annotation1 Publication

GO - Biological processi

  • lipopolysaccharide metabolic process Source: EcoCyc

Keywordsi

Biological processStress response

Enzyme and pathway databases

BioCyciEcoCyc:G6637-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide assembly protein A1 PublicationUniRule annotation
Gene namesi
Name:lapA1 PublicationUniRule annotation
Synonyms:yciS
Ordered Locus Names:b1279, JW1271
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG13904 yciS

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicCurated2
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Topological domaini24 – 43PeriplasmicCuratedAdd BLAST20
Transmembranei44 – 64HelicalUniRule annotationAdd BLAST21
Topological domaini65 – 102Cytoplasmic1 PublicationAdd BLAST38

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Disruption mutant shows accumulation of a few incomplete LPS precursors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001688861 – 102Lipopolysaccharide assembly protein AAdd BLAST102

Proteomic databases

PaxDbiP0ACV4
PRIDEiP0ACV4

Expressioni

Inductioni

Induced by heat shock, via RpoH.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260130, 32 interactors
DIPiDIP-47880N
IntActiP0ACV4, 20 interactors
STRINGi316385.ECDH10B_1396

Structurei

3D structure databases

ProteinModelPortaliP0ACV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili64 – 92UniRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the LapA family.UniRule annotationCurated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105Q4A Bacteria
COG3771 LUCA
HOGENOMiHOG000276312
KOiK08992
OMAiVITFNYL

Family and domain databases

HAMAPiMF_01948 LPS_assembly_LapA, 1 hit
InterProiView protein in InterPro
IPR032906 LapA
IPR010445 LapA_dom
PfamiView protein in Pfam
PF06305 LapA_dom, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYLLIFLLV LAIFVISVTL GAQNDQQVTF NYLLAQGEYR ISTLLAVLFA
60 70 80 90 100
AGFAIGWLIC GLFWLRVRVS LARAERKIKR LENQLSPATD VAVVPHSSAA

KE
Length:102
Mass (Da):11,351
Last modified:November 22, 2005 - v1
Checksum:i716C2881E2E2EDFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74361.1
AP009048 Genomic DNA Translation: BAA14833.1
PIRiB64876
RefSeqiNP_415795.1, NC_000913.3
WP_000876286.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74361; AAC74361; b1279
BAA14833; BAA14833; BAA14833
GeneIDi944936
KEGGiecj:JW1271
eco:b1279
PATRICifig|1411691.4.peg.1002

Entry informationi

Entry nameiLAPA_ECOLI
AccessioniPrimary (citable) accession number: P0ACV4
Secondary accession number(s): P77614
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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