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Protein

Lipopolysaccharide assembly protein A

Gene

lapA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the assembly of lipopolysaccharide (LPS).UniRule annotation1 Publication

GO - Biological processi

  • lipopolysaccharide metabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciEcoCyc:G6637-MONOMER.
ECOL316407:JW1271-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide assembly protein A1 PublicationUniRule annotation
Gene namesi
Name:lapA1 PublicationUniRule annotation
Synonyms:yciS
Ordered Locus Names:b1279, JW1271
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13904. yciS.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22CytoplasmicCurated
Transmembranei3 – 2321HelicalUniRule annotationAdd
BLAST
Topological domaini24 – 4320PeriplasmicCuratedAdd
BLAST
Transmembranei44 – 6421HelicalUniRule annotationAdd
BLAST
Topological domaini65 – 10238Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Disruption mutant shows accumulation of a few incomplete LPS precursors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 102102Lipopolysaccharide assembly protein APRO_0000168886Add
BLAST

Proteomic databases

PaxDbiP0ACV4.

Expressioni

Inductioni

Induced by heat shock, via RpoH.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260130. 22 interactions.
DIPiDIP-47880N.
STRINGi511145.b1279.

Structurei

3D structure databases

ProteinModelPortaliP0ACV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili64 – 9229UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the LapA family.UniRule annotationCurated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105Q4A. Bacteria.
COG3771. LUCA.
HOGENOMiHOG000276312.
KOiK08992.
OMAiQGDYRIS.

Family and domain databases

HAMAPiMF_01948. LPS_assembly_LapA. 1 hit.
InterProiIPR032906. LapA.
IPR010445. LapA_dom.
[Graphical view]
PfamiPF06305. DUF1049. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYLLIFLLV LAIFVISVTL GAQNDQQVTF NYLLAQGEYR ISTLLAVLFA
60 70 80 90 100
AGFAIGWLIC GLFWLRVRVS LARAERKIKR LENQLSPATD VAVVPHSSAA

KE
Length:102
Mass (Da):11,351
Last modified:November 22, 2005 - v1
Checksum:i716C2881E2E2EDFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74361.1.
AP009048 Genomic DNA. Translation: BAA14833.1.
PIRiB64876.
RefSeqiNP_415795.1. NC_000913.3.
WP_000876286.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74361; AAC74361; b1279.
BAA14833; BAA14833; BAA14833.
GeneIDi944936.
KEGGiecj:JW1271.
eco:b1279.
PATRICi32117820. VBIEscCol129921_1330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74361.1.
AP009048 Genomic DNA. Translation: BAA14833.1.
PIRiB64876.
RefSeqiNP_415795.1. NC_000913.3.
WP_000876286.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260130. 22 interactions.
DIPiDIP-47880N.
STRINGi511145.b1279.

Proteomic databases

PaxDbiP0ACV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74361; AAC74361; b1279.
BAA14833; BAA14833; BAA14833.
GeneIDi944936.
KEGGiecj:JW1271.
eco:b1279.
PATRICi32117820. VBIEscCol129921_1330.

Organism-specific databases

EchoBASEiEB3663.
EcoGeneiEG13904. yciS.

Phylogenomic databases

eggNOGiENOG4105Q4A. Bacteria.
COG3771. LUCA.
HOGENOMiHOG000276312.
KOiK08992.
OMAiQGDYRIS.

Enzyme and pathway databases

BioCyciEcoCyc:G6637-MONOMER.
ECOL316407:JW1271-MONOMER.

Miscellaneous databases

PROiP0ACV4.

Family and domain databases

HAMAPiMF_01948. LPS_assembly_LapA. 1 hit.
InterProiIPR032906. LapA.
IPR010445. LapA_dom.
[Graphical view]
PfamiPF06305. DUF1049. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAPA_ECOLI
AccessioniPrimary (citable) accession number: P0ACV4
Secondary accession number(s): P77614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.