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Protein

HTH-type transcriptional repressor FabR

Gene

fabR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5220H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11394-MONOMER.
ECOL316407:JW3935-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor FabR
Gene namesi
Name:fabR
Synonyms:yijC
Ordered Locus Names:b3963, JW3935
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11394. fabR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215HTH-type transcriptional repressor FabRPRO_0000070641Add
BLAST

Proteomic databases

PaxDbiP0ACU5.
PRIDEiP0ACU5.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi4261883. 155 interactions.
DIPiDIP-12520N.
STRINGi511145.b3963.

Structurei

3D structure databases

ProteinModelPortaliP0ACU5.
SMRiP0ACU5. Positions 4-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7061HTH tetR-typeAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EJ2. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000270364.
InParanoidiP0ACU5.
OMAiAYWYRKE.
OrthoDBiEOG6ZPT09.
PhylomeDBiP0ACU5.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_01190. HTH_type_FabR.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR023764. Tscrpt_reg_HTH_FabR.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVRAQQKEK TRRSLVEAAF SQLSAERSFA SLSLREVARE AGIAPTSFYR
60 70 80 90 100
HFRDVDELGL TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG
110 120 130 140 150
NNPNAFRLLL RERSGTSAAF RAAVAREIQH FIAELADYLE LENHMPRAFT
160 170 180 190 200
EAQAEAMVTI VFSAGAEALD VGVEQRRQLE ERLVLQLRMI SKGAYYWYRR
210
EQEKTAIIPG NVKDE
Length:215
Mass (Da):24,404
Last modified:November 22, 2005 - v1
Checksum:iACA9739EA947E256
GO

Sequence cautioni

The sequence AAC43069.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE77348.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA46823.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281S → T in CAA46823 (PubMed:1447162).Curated
Sequence conflicti42 – 421G → V in CAA46823 (PubMed:1447162).Curated
Sequence conflicti69 – 702ML → IV in CAA46823 (PubMed:1447162).Curated
Sequence conflicti74 – 752MR → IG in CAA46823 (PubMed:1447162).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66026 Genomic DNA. Translation: CAA46823.1. Different initiation.
U00006 Genomic DNA. Translation: AAC43069.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76945.2.
AP009048 Genomic DNA. Translation: BAE77348.1. Different initiation.
RefSeqiNP_418398.2. NC_000913.3.
WP_001300495.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76945; AAC76945; b3963.
BAE77348; BAE77348; BAE77348.
GeneIDi948460.
KEGGiecj:JW3935.
eco:b3963.
PATRICi32123447. VBIEscCol129921_4084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66026 Genomic DNA. Translation: CAA46823.1. Different initiation.
U00006 Genomic DNA. Translation: AAC43069.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76945.2.
AP009048 Genomic DNA. Translation: BAE77348.1. Different initiation.
RefSeqiNP_418398.2. NC_000913.3.
WP_001300495.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACU5.
SMRiP0ACU5. Positions 4-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261883. 155 interactions.
DIPiDIP-12520N.
STRINGi511145.b3963.

Proteomic databases

PaxDbiP0ACU5.
PRIDEiP0ACU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76945; AAC76945; b3963.
BAE77348; BAE77348; BAE77348.
GeneIDi948460.
KEGGiecj:JW3935.
eco:b3963.
PATRICi32123447. VBIEscCol129921_4084.

Organism-specific databases

EchoBASEiEB1367.
EcoGeneiEG11394. fabR.

Phylogenomic databases

eggNOGiENOG4105EJ2. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000270364.
InParanoidiP0ACU5.
OMAiAYWYRKE.
OrthoDBiEOG6ZPT09.
PhylomeDBiP0ACU5.

Enzyme and pathway databases

BioCyciEcoCyc:EG11394-MONOMER.
ECOL316407:JW3935-MONOMER.

Miscellaneous databases

PROiP0ACU5.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_01190. HTH_type_FabR.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR023764. Tscrpt_reg_HTH_FabR.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Physical map of the oxyR-trmA region (minute 89.3) of the Escherichia coli chromosome."
    Gustafsson C., Warne S.R.
    J. Bacteriol. 174:7878-7879(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes."
    Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.
    Nucleic Acids Res. 21:5408-5417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes."
    McCue L.A., Thompson W., Carmack C.S., Ryan M.P., Liu J.S., Derbyshire V., Lawrence C.E.
    Nucleic Acids Res. 29:774-782(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, ROLE IN REGULATION OF FATTY ACID BIOSYNTHESIS.
  6. "The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli."
    Zhang Y.-M., Marrakchi H., Rock C.O.
    J. Biol. Chem. 277:15558-15565(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFABR_ECOLI
AccessioniPrimary (citable) accession number: P0ACU5
Secondary accession number(s): P27307, Q2M8Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.