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Protein

HTH-type transcriptional regulator UidR

Gene

uidR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Repressor for the uidRABC (gusRABC) operon.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5220H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6867-MONOMER.
ECOL316407:JW1610-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator UidR
Alternative name(s):
Gus operon repressor
Uid operon repressor
Gene namesi
Name:uidR
Synonyms:gusR
Ordered Locus Names:b1618, JW1610
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12667. uidR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196HTH-type transcriptional regulator UidRPRO_0000070628Add
BLAST

Proteomic databases

PaxDbiP0ACT6.
PRIDEiP0ACT6.

Interactioni

Protein-protein interaction databases

BioGridi4263484. 19 interactions.
DIPiDIP-48053N.
IntActiP0ACT6. 11 interactions.
MINTiMINT-1223157.
STRINGi511145.b1618.

Structurei

3D structure databases

ProteinModelPortaliP0ACT6.
SMRiP0ACT6. Positions 9-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7061HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105XEA. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000215576.
InParanoidiP0ACT6.
KOiK16138.
OMAiELATCCI.
OrthoDBiEOG62NX3S.
PhylomeDBiP0ACT6.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDNMQTEAQ PTRTRILNAA REIFSENGFH SASMKAICKS CAISPGTLYH
60 70 80 90 100
HFISKEALIQ AIILQDQERA LARFREPIEG IHFVDYMVES IVSLTHEAFG
110 120 130 140 150
QRALVVEIMA EGMRNPQVAA MLKNKHMTIT EFVAQRMRDA QQKGEISPDI
160 170 180 190
NTAMTSRLLL DLTYGVLADI EAEDLAREAS FAQGLRAMIG GILTAS
Length:196
Mass (Da):21,799
Last modified:November 22, 2005 - v1
Checksum:i22912EF7695268D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14641 Genomic DNA. Translation: AAA68922.1.
U00096 Genomic DNA. Translation: AAC74690.1.
AP009048 Genomic DNA. Translation: BAA15369.1.
PIRiD64918.
RefSeqiNP_416135.1. NC_000913.3.
WP_000969092.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74690; AAC74690; b1618.
BAA15369; BAA15369; BAA15369.
GeneIDi946150.
KEGGiecj:JW1610.
eco:b1618.
PATRICi32118538. VBIEscCol129921_1689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14641 Genomic DNA. Translation: AAA68922.1.
U00096 Genomic DNA. Translation: AAC74690.1.
AP009048 Genomic DNA. Translation: BAA15369.1.
PIRiD64918.
RefSeqiNP_416135.1. NC_000913.3.
WP_000969092.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACT6.
SMRiP0ACT6. Positions 9-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263484. 19 interactions.
DIPiDIP-48053N.
IntActiP0ACT6. 11 interactions.
MINTiMINT-1223157.
STRINGi511145.b1618.

Proteomic databases

PaxDbiP0ACT6.
PRIDEiP0ACT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74690; AAC74690; b1618.
BAA15369; BAA15369; BAA15369.
GeneIDi946150.
KEGGiecj:JW1610.
eco:b1618.
PATRICi32118538. VBIEscCol129921_1689.

Organism-specific databases

EchoBASEiEB2533.
EcoGeneiEG12667. uidR.

Phylogenomic databases

eggNOGiENOG4105XEA. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000215576.
InParanoidiP0ACT6.
KOiK16138.
OMAiELATCCI.
OrthoDBiEOG62NX3S.
PhylomeDBiP0ACT6.

Enzyme and pathway databases

BioCyciEcoCyc:G6867-MONOMER.
ECOL316407:JW1610-MONOMER.

Miscellaneous databases

PROiP0ACT6.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The GusR repressor of Esherichia coli."
    Wilson K.J., Jefferson R.A.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiUIDR_ECOLI
AccessioniPrimary (citable) accession number: P0ACT6
Secondary accession number(s): P76892, P76895, Q59431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.