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Protein

Probable acrEF/envCD operon repressor

Gene

envR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Potential regulator protein for the acrEF/envCD genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5220H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to drug Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11741-MONOMER.
ECOL316407:JW3232-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acrEF/envCD operon repressor
Gene namesi
Name:envR
Synonyms:yhdK
Ordered Locus Names:b3264, JW3232
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11741. envR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Probable acrEF/envCD operon repressorPRO_0000070593Add
BLAST

Proteomic databases

PaxDbiP0ACT2.

Interactioni

Protein-protein interaction databases

BioGridi4261952. 13 interactions.
IntActiP0ACT2. 7 interactions.
STRINGi511145.b3264.

Structurei

3D structure databases

ProteinModelPortaliP0ACT2.
SMRiP0ACT2. Positions 1-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7061HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108XG4. Bacteria.
ENOG4111M3K. LUCA.
HOGENOMiHOG000260115.
InParanoidiP0ACT2.
KOiK18140.
OMAiPRQRALM.
PhylomeDBiP0ACT2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR013572. Tscrpt_reg_MAATS_C.
[Graphical view]
PfamiPF08361. TetR_C_2. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRTKAEAL KTRQELIETA IAQFAQHGVS KTTLNDIADA ANVTRGAIYW
60 70 80 90 100
HFENKTQLFN EMWLQQPSLR ELIQEHLTAG LEHDPFQQLR EKLIVGLQYI
110 120 130 140 150
AKIPRQQALL KILYHKCEFN DEMLAEGVIR EKMGFNPQTL REVLQACQQQ
160 170 180 190 200
GCVANNLDLD VVMIIIDGAF SGIVQNWLMN MAGYDLYKQA PALVDNVLRM
210 220
FMPDENITKL IHQTNELSVM
Length:220
Mass (Da):25,198
Last modified:November 22, 2005 - v1
Checksum:i024F98B20698D0F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57948 Genomic DNA. Translation: CAA41015.1.
U18997 Genomic DNA. Translation: AAA58068.1.
U00096 Genomic DNA. Translation: AAC76296.1.
AP009048 Genomic DNA. Translation: BAE77305.1.
PIRiB65119.
RefSeqiNP_417730.1. NC_000913.3.
WP_001129518.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76296; AAC76296; b3264.
BAE77305; BAE77305; BAE77305.
GeneIDi947704.
KEGGiecj:JW3232.
eco:b3264.
PATRICi32121958. VBIEscCol129921_3363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57948 Genomic DNA. Translation: CAA41015.1.
U18997 Genomic DNA. Translation: AAA58068.1.
U00096 Genomic DNA. Translation: AAC76296.1.
AP009048 Genomic DNA. Translation: BAE77305.1.
PIRiB65119.
RefSeqiNP_417730.1. NC_000913.3.
WP_001129518.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACT2.
SMRiP0ACT2. Positions 1-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261952. 13 interactions.
IntActiP0ACT2. 7 interactions.
STRINGi511145.b3264.

Proteomic databases

PaxDbiP0ACT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76296; AAC76296; b3264.
BAE77305; BAE77305; BAE77305.
GeneIDi947704.
KEGGiecj:JW3232.
eco:b3264.
PATRICi32121958. VBIEscCol129921_3363.

Organism-specific databases

EchoBASEiEB1692.
EcoGeneiEG11741. envR.

Phylogenomic databases

eggNOGiENOG4108XG4. Bacteria.
ENOG4111M3K. LUCA.
HOGENOMiHOG000260115.
InParanoidiP0ACT2.
KOiK18140.
OMAiPRQRALM.
PhylomeDBiP0ACT2.

Enzyme and pathway databases

BioCyciEcoCyc:EG11741-MONOMER.
ECOL316407:JW3232-MONOMER.

Miscellaneous databases

PROiP0ACT2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR013572. Tscrpt_reg_MAATS_C.
[Graphical view]
PfamiPF08361. TetR_C_2. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENVR_ECOLI
AccessioniPrimary (citable) accession number: P0ACT2
Secondary accession number(s): P31676, Q2M8V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.