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Protein

Probable acrEF/envCD operon repressor

Gene

envR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Potential regulator protein for the acrEF/envCD genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to drug Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG11741-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acrEF/envCD operon repressor
Gene namesi
Name:envR
Synonyms:yhdK
Ordered Locus Names:b3264, JW3232
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11741 envR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000705931 – 220Probable acrEF/envCD operon repressorAdd BLAST220

Proteomic databases

PaxDbiP0ACT2
PRIDEiP0ACT2

Interactioni

Protein-protein interaction databases

BioGridi4261952, 13 interactors
IntActiP0ACT2, 7 interactors

Structurei

3D structure databases

ProteinModelPortaliP0ACT2
SMRiP0ACT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 70HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG4108XG4 Bacteria
ENOG4111M3K LUCA
HOGENOMiHOG000260115
InParanoidiP0ACT2
KOiK18140
OMAiAVYWHFA
PhylomeDBiP0ACT2

Family and domain databases

InterProiView protein in InterPro
IPR023772 DNA-bd_HTH_TetR-type_CS
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR036271 Tet_transcr_reg_TetR-rel_C_sf
IPR013572 Tscrpt_reg_MAATS_C
PfamiView protein in Pfam
PF08361 TetR_C_2, 1 hit
PF00440 TetR_N, 1 hit
PRINTSiPR00455 HTHTETR
SUPFAMiSSF46689 SSF46689, 1 hit
SSF48498 SSF48498, 1 hit
PROSITEiView protein in PROSITE
PS01081 HTH_TETR_1, 1 hit
PS50977 HTH_TETR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRTKAEAL KTRQELIETA IAQFAQHGVS KTTLNDIADA ANVTRGAIYW
60 70 80 90 100
HFENKTQLFN EMWLQQPSLR ELIQEHLTAG LEHDPFQQLR EKLIVGLQYI
110 120 130 140 150
AKIPRQQALL KILYHKCEFN DEMLAEGVIR EKMGFNPQTL REVLQACQQQ
160 170 180 190 200
GCVANNLDLD VVMIIIDGAF SGIVQNWLMN MAGYDLYKQA PALVDNVLRM
210 220
FMPDENITKL IHQTNELSVM
Length:220
Mass (Da):25,198
Last modified:November 22, 2005 - v1
Checksum:i024F98B20698D0F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57948 Genomic DNA Translation: CAA41015.1
U18997 Genomic DNA Translation: AAA58068.1
U00096 Genomic DNA Translation: AAC76296.1
AP009048 Genomic DNA Translation: BAE77305.1
PIRiB65119
RefSeqiNP_417730.1, NC_000913.3
WP_001129518.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76296; AAC76296; b3264
BAE77305; BAE77305; BAE77305
GeneIDi947704
KEGGiecj:JW3232
eco:b3264
PATRICifig|1411691.4.peg.3464

Similar proteinsi

Entry informationi

Entry nameiENVR_ECOLI
AccessioniPrimary (citable) accession number: P0ACT2
Secondary accession number(s): P31676, Q2M8V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health