HTH-type transcriptional regulator acrR - Escherichia coli (strain K12)

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Reviewed, UniProtKB/Swiss-Prot P0ACS9 (ACRR_ECOLI)

Last modified November 24, 2009. Version 34. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
HTH-type transcriptional regulator acrR
Alternative name(s):
Potential acrAB operon repressor

Gene names

Name:	acrR
Synonyms:	ybaH
Ordered Locus Names:	b0464, JW0453

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Potential regulator protein for the acrAB genes.
Sequence similarities	Contains 1 HTH tetR-type DNA-binding domain.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
glpD	P13035	1	EBI-1117360,EBI-548509

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 215

215

HTH-type transcriptional regulator acrR

PRO_0000070573

Regions

Domain

10 – 70

HTH tetR-type

DNA binding

33 – 52

H-T-H motif Potential

Secondary structure

215

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P0ACS9-1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: CB002F8DC1F682BB
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FASTA

215

24,767

        10         20         30         40         50         60 
MARKTKQEAQ ETRQHILDVA LRLFSQQGVS STSLGEIAKA AGVTRGAIYW HFKDKSDLFS 

        70         80         90        100        110        120 
EIWELSESNI GELELEYQAK FPGDPLSVLR EILIHVLEST VTEERRRLLM EIIFHKCEFV 

       130        140        150        160        170        180 
GEMAVVQQAQ RNLCLESYDR IEQTLKHCIE AKMLPADLMT RRAAIIMRGY ISGLMENWLF 

       190        200        210 
APQSFDLKKE ARDYVAILLE MYLLCPTLRN PATNE

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of acrA and acrE genes of Escherichia coli." Ma D., Cook D.N., Alberti M., Pon N.G., Nikaido H., Hearst J.E. J. Bacteriol. 175:6299-6313(1993) [PubMed: 8407802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W4573.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	Rudd K.E. Unpublished observations (DEC-1993) Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

U00734 Genomic DNA. Translation: AAA67133.1.
U82664 Genomic DNA. Translation: AAB40218.1.
U00096 Genomic DNA. Translation: AAC73566.1.
AP009048 Genomic DNA. Translation: BAE76243.1.

PIR

G64776.

RefSeq

AP_001113.1.
NP_414997.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2QOP	X-ray	2.55	A	1-215	[»]
3BCG	X-ray	2.48	A/B	1-215	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P0ACS9. 1 interaction.

STRING

P0ACS9.

Genome annotation databases

GeneID

945516.

GenomeReviews

Gene locus JW0453 in contig AP009048_GR.
Gene locus b0464 in contig U00096_GR.

KEGG

ecj:JW0453.
eco:b0464.

Organism-specific databases

EchoBASE

EB2039.

EcoGene

EG12116. acrR.

CMR

Search...

Phylogenomic databases

HOGENOM

P0ACS9.

OMA

TRRINEI

Enzyme and pathway databases

BioCyc

EcoCyc:EG12116-MON.
ECOL168927:B0464-MON.

Gene expression databases

Genevestigator

P0ACS9.

Family and domain databases

InterPro

IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR001647. Transcr-reg_TetR-like_bac/arc.
IPR013572. Transcr_reg_MAATS_C.
[Graphical view]

Gene3D

G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.

Pfam

PF08361. TetR_C_2. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]

PRINTS

PR00455. HTHTETR.

PROSITE

PS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

ACRR_ECOLI

Accession

Primary (citable) accession number: P0ACS9
Secondary accession number(s): P34000, Q2MBW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	November 24, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents