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Protein

HTH-type transcriptional regulator AcrR

Gene

acrR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential regulator protein for the acrAB genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • drug binding Source: EcoCyc
  • sequence-specific DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to drug Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12116-MONOMER.
ECOL316407:JW0453-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator AcrR
Alternative name(s):
Potential acrAB operon repressor
Gene namesi
Name:acrR
Synonyms:ybaH
Ordered Locus Names:b0464, JW0453
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12116. acrR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000705731 – 215HTH-type transcriptional regulator AcrRAdd BLAST215

Proteomic databases

PaxDbiP0ACS9.
PRIDEiP0ACS9.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
astEP762153EBI-1117360,EBI-1121806

Protein-protein interaction databases

BioGridi4260988. 9 interactors.
IntActiP0ACS9. 19 interactors.
STRINGi511145.b0464.

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 27Combined sources19
Turni28 – 31Combined sources4
Helixi34 – 41Combined sources8
Helixi45 – 51Combined sources7
Beta strandi53 – 55Combined sources3
Helixi56 – 64Combined sources9
Helixi74 – 77Combined sources4
Turni78 – 80Combined sources3
Beta strandi81 – 83Combined sources3
Helixi86 – 102Combined sources17
Helixi104 – 115Combined sources12
Turni121 – 124Combined sources4
Helixi125 – 150Combined sources26
Helixi162 – 180Combined sources19
Turni182 – 184Combined sources3
Helixi187 – 204Combined sources18
Beta strandi206 – 208Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QOPX-ray2.55A1-215[»]
3BCGX-ray2.48A/B1-215[»]
ProteinModelPortaliP0ACS9.
SMRiP0ACS9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACS9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 70HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107XI7. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000260115.
InParanoidiP0ACS9.
KOiK03577.
OMAiMMEIIFH.
PhylomeDBiP0ACS9.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR013572. Tscrpt_reg_MAATS_C.
[Graphical view]
PfamiPF08361. TetR_C_2. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKTKQEAQ ETRQHILDVA LRLFSQQGVS STSLGEIAKA AGVTRGAIYW
60 70 80 90 100
HFKDKSDLFS EIWELSESNI GELELEYQAK FPGDPLSVLR EILIHVLEST
110 120 130 140 150
VTEERRRLLM EIIFHKCEFV GEMAVVQQAQ RNLCLESYDR IEQTLKHCIE
160 170 180 190 200
AKMLPADLMT RRAAIIMRGY ISGLMENWLF APQSFDLKKE ARDYVAILLE
210
MYLLCPTLRN PATNE
Length:215
Mass (Da):24,767
Last modified:November 22, 2005 - v1
Checksum:iCB002F8DC1F682BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00734 Genomic DNA. Translation: AAA67133.1.
U82664 Genomic DNA. Translation: AAB40218.1.
U00096 Genomic DNA. Translation: AAC73566.1.
AP009048 Genomic DNA. Translation: BAE76243.1.
PIRiG64776.
RefSeqiNP_414997.1. NC_000913.3.
WP_000101737.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73566; AAC73566; b0464.
BAE76243; BAE76243; BAE76243.
GeneIDi945516.
KEGGiecj:JW0453.
eco:b0464.
PATRICi32116081. VBIEscCol129921_0482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00734 Genomic DNA. Translation: AAA67133.1.
U82664 Genomic DNA. Translation: AAB40218.1.
U00096 Genomic DNA. Translation: AAC73566.1.
AP009048 Genomic DNA. Translation: BAE76243.1.
PIRiG64776.
RefSeqiNP_414997.1. NC_000913.3.
WP_000101737.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QOPX-ray2.55A1-215[»]
3BCGX-ray2.48A/B1-215[»]
ProteinModelPortaliP0ACS9.
SMRiP0ACS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260988. 9 interactors.
IntActiP0ACS9. 19 interactors.
STRINGi511145.b0464.

Proteomic databases

PaxDbiP0ACS9.
PRIDEiP0ACS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73566; AAC73566; b0464.
BAE76243; BAE76243; BAE76243.
GeneIDi945516.
KEGGiecj:JW0453.
eco:b0464.
PATRICi32116081. VBIEscCol129921_0482.

Organism-specific databases

EchoBASEiEB2039.
EcoGeneiEG12116. acrR.

Phylogenomic databases

eggNOGiENOG4107XI7. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000260115.
InParanoidiP0ACS9.
KOiK03577.
OMAiMMEIIFH.
PhylomeDBiP0ACS9.

Enzyme and pathway databases

BioCyciEcoCyc:EG12116-MONOMER.
ECOL316407:JW0453-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ACS9.
PROiP0ACS9.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR013572. Tscrpt_reg_MAATS_C.
[Graphical view]
PfamiPF08361. TetR_C_2. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACRR_ECOLI
AccessioniPrimary (citable) accession number: P0ACS9
Secondary accession number(s): P34000, Q2MBW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.