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Protein

HTH-type transcriptional regulator AcrR

Gene

acrR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential regulator protein for the acrAB genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding transcription factor activity Source: EcoCyc
  • drug binding Source: EcoCyc
  • sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to drug Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12116-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator AcrR
Alternative name(s):
Potential acrAB operon repressor
Gene namesi
Name:acrR
Synonyms:ybaH
Ordered Locus Names:b0464, JW0453
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12116 acrR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000705731 – 215HTH-type transcriptional regulator AcrRAdd BLAST215

Proteomic databases

PaxDbiP0ACS9
PRIDEiP0ACS9

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
astEP762153EBI-1117360,EBI-1121806

Protein-protein interaction databases

BioGridi4260988, 9 interactors
IntActiP0ACS9, 18 interactors
STRINGi316385.ECDH10B_0420

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 27Combined sources19
Turni28 – 31Combined sources4
Helixi34 – 41Combined sources8
Helixi45 – 51Combined sources7
Beta strandi53 – 55Combined sources3
Helixi56 – 64Combined sources9
Helixi74 – 77Combined sources4
Turni78 – 80Combined sources3
Beta strandi81 – 83Combined sources3
Helixi86 – 102Combined sources17
Helixi104 – 115Combined sources12
Turni121 – 124Combined sources4
Helixi125 – 150Combined sources26
Helixi162 – 180Combined sources19
Turni182 – 184Combined sources3
Helixi187 – 204Combined sources18
Beta strandi206 – 208Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QOPX-ray2.55A1-215[»]
3BCGX-ray2.48A/B1-215[»]
ProteinModelPortaliP0ACS9
SMRiP0ACS9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACS9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 70HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG4107XI7 Bacteria
COG1309 LUCA
HOGENOMiHOG000260115
InParanoidiP0ACS9
KOiK03577
OMAiMMEIIFH
PhylomeDBiP0ACS9

Family and domain databases

InterProiView protein in InterPro
IPR023772 DNA-bd_HTH_TetR-type_CS
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR036271 Tet_transcr_reg_TetR-rel_C_sf
IPR013572 Tscrpt_reg_MAATS_C
PfamiView protein in Pfam
PF08361 TetR_C_2, 1 hit
PF00440 TetR_N, 1 hit
PRINTSiPR00455 HTHTETR
SUPFAMiSSF46689 SSF46689, 1 hit
SSF48498 SSF48498, 1 hit
PROSITEiView protein in PROSITE
PS01081 HTH_TETR_1, 1 hit
PS50977 HTH_TETR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKTKQEAQ ETRQHILDVA LRLFSQQGVS STSLGEIAKA AGVTRGAIYW
60 70 80 90 100
HFKDKSDLFS EIWELSESNI GELELEYQAK FPGDPLSVLR EILIHVLEST
110 120 130 140 150
VTEERRRLLM EIIFHKCEFV GEMAVVQQAQ RNLCLESYDR IEQTLKHCIE
160 170 180 190 200
AKMLPADLMT RRAAIIMRGY ISGLMENWLF APQSFDLKKE ARDYVAILLE
210
MYLLCPTLRN PATNE
Length:215
Mass (Da):24,767
Last modified:November 22, 2005 - v1
Checksum:iCB002F8DC1F682BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00734 Genomic DNA Translation: AAA67133.1
U82664 Genomic DNA Translation: AAB40218.1
U00096 Genomic DNA Translation: AAC73566.1
AP009048 Genomic DNA Translation: BAE76243.1
PIRiG64776
RefSeqiNP_414997.1, NC_000913.3
WP_000101737.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73566; AAC73566; b0464
BAE76243; BAE76243; BAE76243
GeneIDi945516
KEGGiecj:JW0453
eco:b0464
PATRICifig|1411691.4.peg.1812

Similar proteinsi

Entry informationi

Entry nameiACRR_ECOLI
AccessioniPrimary (citable) accession number: P0ACS9
Secondary accession number(s): P34000, Q2MBW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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