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P0ACS7

- RPIR_ECOLI

UniProt

P0ACS7 - RPIR_ECOLI

Protein

HTH-type transcriptional regulator RpiR

Gene

rpiR

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Regulatory protein involved in rpiB gene repression. Also involved in als operon repression.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi50 – 6920H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. negative regulation of transcription, DNA-templated Source: EcoCyc
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:G7821-MONOMER.
    ECOL316407:JW4050-MONOMER.
    RETL1328306-WGS:GSTH-5049-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator RpiR
    Alternative name(s):
    Als operon repressor
    Gene namesi
    Name:rpiR
    Synonyms:alsR, yjcY
    Ordered Locus Names:b4089, JW4050
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG12459. rpiR.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296HTH-type transcriptional regulator RpiRPRO_0000068620Add
    BLAST

    Proteomic databases

    PRIDEiP0ACS7.

    Expressioni

    Gene expression databases

    GenevestigatoriP0ACS7.

    Interactioni

    Protein-protein interaction databases

    IntActiP0ACS7. 5 interactions.
    STRINGi511145.b4089.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ACS7.
    SMRiP0ACS7. Positions 20-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 9077HTH rpiR-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 274141SISPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH rpiR-type DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 SIS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1737.
    HOGENOMiHOG000027157.
    OMAiNYAESPI.
    OrthoDBiEOG6HMXHM.
    PhylomeDBiP0ACS7.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR000281. HTH_RpiR.
    IPR001347. SIS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01418. HTH_6. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51071. HTH_RPIR. 1 hit.
    PS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0ACS7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSEFDSAL PNGIGLAPYL RMKQEGMTEN ESRIVEWLLK PGNLSCAPAI    50
    KDVAEALAVS EAMIVKVSKL LGFSGFRNLR SALEDYFSQS EQVLPSELAF 100
    DEAPQDVVNK VFNITLRTIM EGQSIVNVDE IHRAARFFYQ ARQRDLYGAG 150
    GSNAICADVQ HKFLRIGVRC QAYPDAHIMM MSASLLQEGD VVLVVTHSGR 200
    TSDVKAAVEL AKKNGAKIIC ITHSYHSPIA KLADYIICSP APETPLLGRN 250
    ASARILQLTL LDAFFVSVAQ LNIEQANINM QKTGAIVDFF SPGALK 296
    Length:296
    Mass (Da):32,362
    Last modified:November 22, 2005 - v1
    Checksum:i7946848F0798E200
    GO

    Sequence cautioni

    The sequence AAA96988.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82203 Genomic DNA. Translation: CAA57687.1.
    U14003 Genomic DNA. Translation: AAA96988.1. Different initiation.
    U00096 Genomic DNA. Translation: AAC77050.2.
    AP009048 Genomic DNA. Translation: BAE78092.1.
    PIRiS56317.
    RefSeqiNP_418513.4. NC_000913.3.
    YP_492233.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC77050; AAC77050; b4089.
    BAE78092; BAE78092; BAE78092.
    GeneIDi12933688.
    948603.
    KEGGiecj:Y75_p3977.
    eco:b4089.
    PATRICi32123735. VBIEscCol129921_4216.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82203 Genomic DNA. Translation: CAA57687.1 .
    U14003 Genomic DNA. Translation: AAA96988.1 . Different initiation.
    U00096 Genomic DNA. Translation: AAC77050.2 .
    AP009048 Genomic DNA. Translation: BAE78092.1 .
    PIRi S56317.
    RefSeqi NP_418513.4. NC_000913.3.
    YP_492233.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0ACS7.
    SMRi P0ACS7. Positions 20-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0ACS7. 5 interactions.
    STRINGi 511145.b4089.

    Proteomic databases

    PRIDEi P0ACS7.

    Protocols and materials databases

    DNASUi 948603.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC77050 ; AAC77050 ; b4089 .
    BAE78092 ; BAE78092 ; BAE78092 .
    GeneIDi 12933688.
    948603.
    KEGGi ecj:Y75_p3977.
    eco:b4089.
    PATRICi 32123735. VBIEscCol129921_4216.

    Organism-specific databases

    EchoBASEi EB2353.
    EcoGenei EG12459. rpiR.

    Phylogenomic databases

    eggNOGi COG1737.
    HOGENOMi HOG000027157.
    OMAi NYAESPI.
    OrthoDBi EOG6HMXHM.
    PhylomeDBi P0ACS7.

    Enzyme and pathway databases

    BioCyci EcoCyc:G7821-MONOMER.
    ECOL316407:JW4050-MONOMER.
    RETL1328306-WGS:GSTH-5049-MONOMER.

    Miscellaneous databases

    PROi P0ACS7.

    Gene expression databases

    Genevestigatori P0ACS7.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR000281. HTH_RpiR.
    IPR001347. SIS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01418. HTH_6. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51071. HTH_RPIR. 1 hit.
    PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ribose catabolism of Escherichia coli: characterization of the rpiB gene encoding ribose phosphate isomerase B and of the rpiR gene, which is involved in regulation of rpiB expression."
      Soerensen K.I., Hove-Jensen B.
      J. Bacteriol. 178:1003-1011(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
      Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
      Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "The D-allose operon of Escherichia coli K-12."
      Kim C., Song S., Park C.
      J. Bacteriol. 179:7631-7637(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ALS REPRESSION.

    Entry informationi

    Entry nameiRPIR_ECOLI
    AccessioniPrimary (citable) accession number: P0ACS7
    Secondary accession number(s): P39266, P76791, Q2M6L4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3