Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional regulator ZntR

Gene

zntR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Zinc-responsive transcriptional regulator of zntA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi114Zinc1
Metal bindingi115Zinc1
Metal bindingi119Zinc1
Metal bindingi124Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG11969-MONOMER.
ECOL316407:JW3254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ZntR
Alternative name(s):
Zn(II)-responsive regulator of zntA
Gene namesi
Name:zntR
Synonyms:yhdM
Ordered Locus Names:b3292, JW3254
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11969. zntR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981601 – 141HTH-type transcriptional regulator ZntRAdd BLAST141

Proteomic databases

PaxDbiP0ACS5.
PRIDEiP0ACS5.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi4263395. 8 interactors.
DIPiDIP-48253N.
IntActiP0ACS5. 5 interactors.
STRINGi511145.b3292.

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 56Combined sources13
Helixi61 – 72Combined sources12
Helixi74 – 76Combined sources3
Helixi79 – 113Combined sources35
Beta strandi117 – 120Combined sources4
Helixi121 – 123Combined sources3
Helixi125 – 132Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q08X-ray1.90A/B43-141[»]
1Q09X-ray2.50A43-141[»]
1Q0AX-ray2.00A/B43-141[»]
ProteinModelPortaliP0ACS5.
SMRiP0ACS5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACS5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 70HTH merR-typePROSITE-ProRule annotationAdd BLAST70

Sequence similaritiesi

Contains 1 HTH merR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105W1Y. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000266084.
InParanoidiP0ACS5.
KOiK13638.
OMAiHDIRTEG.
PhylomeDBiP0ACS5.

Family and domain databases

InterProiIPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
IPR011788. ZntR.
[Graphical view]
PfamiPF13411. MerR_1. 1 hit.
[Graphical view]
PRINTSiPR00040. HTHMERR.
SMARTiSM00422. HTH_MERR. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR02043. ZntR. 1 hit.
PROSITEiPS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRIGELAKM AEVTPDTIRY YEKQQMMEHE VRTEGGFRLY TESDLQRLKF
60 70 80 90 100
IRHARQLGFS LESIRELLSI RIDPEHHTCQ ESKGIVQERL QEVEARIAEL
110 120 130 140
QSMQRSLQRL NDACCGTAHS SVYCSILEAL EQGASGVKSG C
Length:141
Mass (Da):16,179
Last modified:November 22, 2005 - v1
Checksum:iEB451201C8BDCE20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29458 Genomic DNA. Translation: AAA24773.1.
U18997 Genomic DNA. Translation: AAA58089.1.
U00096 Genomic DNA. Translation: AAC76317.1.
AP009048 Genomic DNA. Translation: BAE77999.1.
PIRiI67892.
RefSeqiNP_417751.1. NC_000913.3.
WP_000285607.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76317; AAC76317; b3292.
BAE77999; BAE77999; BAE77999.
GeneIDi947786.
KEGGiecj:JW3254.
eco:b3292.
PATRICi32122016. VBIEscCol129921_3385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29458 Genomic DNA. Translation: AAA24773.1.
U18997 Genomic DNA. Translation: AAA58089.1.
U00096 Genomic DNA. Translation: AAC76317.1.
AP009048 Genomic DNA. Translation: BAE77999.1.
PIRiI67892.
RefSeqiNP_417751.1. NC_000913.3.
WP_000285607.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q08X-ray1.90A/B43-141[»]
1Q09X-ray2.50A43-141[»]
1Q0AX-ray2.00A/B43-141[»]
ProteinModelPortaliP0ACS5.
SMRiP0ACS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263395. 8 interactors.
DIPiDIP-48253N.
IntActiP0ACS5. 5 interactors.
STRINGi511145.b3292.

Proteomic databases

PaxDbiP0ACS5.
PRIDEiP0ACS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76317; AAC76317; b3292.
BAE77999; BAE77999; BAE77999.
GeneIDi947786.
KEGGiecj:JW3254.
eco:b3292.
PATRICi32122016. VBIEscCol129921_3385.

Organism-specific databases

EchoBASEiEB1912.
EcoGeneiEG11969. zntR.

Phylogenomic databases

eggNOGiENOG4105W1Y. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000266084.
InParanoidiP0ACS5.
KOiK13638.
OMAiHDIRTEG.
PhylomeDBiP0ACS5.

Enzyme and pathway databases

BioCyciEcoCyc:EG11969-MONOMER.
ECOL316407:JW3254-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ACS5.
PROiP0ACS5.

Family and domain databases

InterProiIPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
IPR011788. ZntR.
[Graphical view]
PfamiPF13411. MerR_1. 1 hit.
[Graphical view]
PRINTSiPR00040. HTHMERR.
SMARTiSM00422. HTH_MERR. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR02043. ZntR. 1 hit.
PROSITEiPS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNTR_ECOLI
AccessioniPrimary (citable) accession number: P0ACS5
Secondary accession number(s): P36676, Q2M6V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.