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Protein

HTH-type transcriptional regulator ZntR

Gene

zntR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Zinc-responsive transcriptional regulator of zntA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi114 – 1141Zinc
Metal bindingi115 – 1151Zinc
Metal bindingi119 – 1191Zinc
Metal bindingi124 – 1241Zinc

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi4 – 2320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG11969-MONOMER.
ECOL316407:JW3254-MONOMER.
RETL1328306-WGS:GSTH-3795-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ZntR
Alternative name(s):
Zn(II)-responsive regulator of zntA
Gene namesi
Name:zntR
Synonyms:yhdM
Ordered Locus Names:b3292, JW3254
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11969. zntR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141HTH-type transcriptional regulator ZntRPRO_0000098160Add
BLAST

Proteomic databases

PaxDbiP0ACS5.
PRIDEiP0ACS5.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi4263395. 8 interactions.
DIPiDIP-48253N.
IntActiP0ACS5. 5 interactions.
STRINGi511145.b3292.

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi44 – 5613Combined sources
Helixi61 – 7212Combined sources
Helixi74 – 763Combined sources
Helixi79 – 11335Combined sources
Beta strandi117 – 1204Combined sources
Helixi121 – 1233Combined sources
Helixi125 – 1328Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q08X-ray1.90A/B43-141[»]
1Q09X-ray2.50A43-141[»]
1Q0AX-ray2.00A/B43-141[»]
ProteinModelPortaliP0ACS5.
SMRiP0ACS5. Positions 43-136.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACS5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7070HTH merR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH merR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105W1Y. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000266084.
InParanoidiP0ACS5.
KOiK13638.
OMAiHDIRTEG.
OrthoDBiEOG6NKQXH.
PhylomeDBiP0ACS5.

Family and domain databases

InterProiIPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
IPR011788. ZntR.
[Graphical view]
PfamiPF13411. MerR_1. 1 hit.
[Graphical view]
PRINTSiPR00040. HTHMERR.
SMARTiSM00422. HTH_MERR. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR02043. ZntR. 1 hit.
PROSITEiPS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRIGELAKM AEVTPDTIRY YEKQQMMEHE VRTEGGFRLY TESDLQRLKF
60 70 80 90 100
IRHARQLGFS LESIRELLSI RIDPEHHTCQ ESKGIVQERL QEVEARIAEL
110 120 130 140
QSMQRSLQRL NDACCGTAHS SVYCSILEAL EQGASGVKSG C
Length:141
Mass (Da):16,179
Last modified:November 22, 2005 - v1
Checksum:iEB451201C8BDCE20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29458 Genomic DNA. Translation: AAA24773.1.
U18997 Genomic DNA. Translation: AAA58089.1.
U00096 Genomic DNA. Translation: AAC76317.1.
AP009048 Genomic DNA. Translation: BAE77999.1.
PIRiI67892.
RefSeqiNP_417751.1. NC_000913.3.
WP_000285607.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76317; AAC76317; b3292.
BAE77999; BAE77999; BAE77999.
GeneIDi947786.
KEGGiecj:JW3254.
eco:b3292.
PATRICi32122016. VBIEscCol129921_3385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29458 Genomic DNA. Translation: AAA24773.1.
U18997 Genomic DNA. Translation: AAA58089.1.
U00096 Genomic DNA. Translation: AAC76317.1.
AP009048 Genomic DNA. Translation: BAE77999.1.
PIRiI67892.
RefSeqiNP_417751.1. NC_000913.3.
WP_000285607.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q08X-ray1.90A/B43-141[»]
1Q09X-ray2.50A43-141[»]
1Q0AX-ray2.00A/B43-141[»]
ProteinModelPortaliP0ACS5.
SMRiP0ACS5. Positions 43-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263395. 8 interactions.
DIPiDIP-48253N.
IntActiP0ACS5. 5 interactions.
STRINGi511145.b3292.

Proteomic databases

PaxDbiP0ACS5.
PRIDEiP0ACS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76317; AAC76317; b3292.
BAE77999; BAE77999; BAE77999.
GeneIDi947786.
KEGGiecj:JW3254.
eco:b3292.
PATRICi32122016. VBIEscCol129921_3385.

Organism-specific databases

EchoBASEiEB1912.
EcoGeneiEG11969. zntR.

Phylogenomic databases

eggNOGiENOG4105W1Y. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000266084.
InParanoidiP0ACS5.
KOiK13638.
OMAiHDIRTEG.
OrthoDBiEOG6NKQXH.
PhylomeDBiP0ACS5.

Enzyme and pathway databases

BioCyciEcoCyc:EG11969-MONOMER.
ECOL316407:JW3254-MONOMER.
RETL1328306-WGS:GSTH-3795-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ACS5.
PROiP0ACS5.

Family and domain databases

InterProiIPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
IPR011788. ZntR.
[Graphical view]
PfamiPF13411. MerR_1. 1 hit.
[Graphical view]
PRINTSiPR00040. HTHMERR.
SMARTiSM00422. HTH_MERR. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR02043. ZntR. 1 hit.
PROSITEiPS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A merR homologue at 74 minutes on the Escherichia coli genome."
    Christie G.E., White T.J., Goodwin T.S.
    Gene 146:131-132(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "ZntR is a Zn(II)-responsive MerR-like transcriptional regulator of zntA in Escherichia coli."
    Brocklehurst K.R., Hobman J.L., Lawley B., Blank L., Marshall S.J., Brown N.L., Morby A.P.
    Mol. Microbiol. 31:893-902(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR."
    Changela A., Chen K., Xue Y., Holschen J., Outten C.E., O'Halloran T.V., Mondragon A.
    Science 301:1383-1387(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

Entry informationi

Entry nameiZNTR_ECOLI
AccessioniPrimary (citable) accession number: P0ACS5
Secondary accession number(s): P36676, Q2M6V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: January 20, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.