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Protein

HTH-type transcriptional regulator ZntR

Gene

zntR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Zinc-responsive transcriptional regulator of zntA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi114Zinc1
Metal bindingi115Zinc1
Metal bindingi119Zinc1
Metal bindingi124Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • bacterial-type proximal promoter sequence-specific DNA binding Source: EcoCyc
  • DNA binding transcription factor activity Source: EcoCyc
  • transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding Source: EcoCyc
  • zinc ion binding Source: EcoCyc

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG11969-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ZntR
Alternative name(s):
Zn(II)-responsive regulator of zntA
Gene namesi
Name:zntR
Synonyms:yhdM
Ordered Locus Names:b3292, JW3254
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11969 zntR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981601 – 141HTH-type transcriptional regulator ZntRAdd BLAST141

Proteomic databases

PaxDbiP0ACS5
PRIDEiP0ACS5

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
nagKP759592EBI-562184,EBI-556240

Protein-protein interaction databases

BioGridi4263395, 8 interactors
DIPiDIP-48253N
IntActiP0ACS5, 5 interactors
STRINGi316385.ECDH10B_3467

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 56Combined sources13
Helixi61 – 72Combined sources12
Helixi74 – 76Combined sources3
Helixi79 – 113Combined sources35
Beta strandi117 – 120Combined sources4
Helixi121 – 123Combined sources3
Helixi125 – 132Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q08X-ray1.90A/B43-141[»]
1Q09X-ray2.50A43-141[»]
1Q0AX-ray2.00A/B43-141[»]
ProteinModelPortaliP0ACS5
SMRiP0ACS5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACS5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 70HTH merR-typePROSITE-ProRule annotationAdd BLAST70

Phylogenomic databases

eggNOGiENOG4105W1Y Bacteria
COG0789 LUCA
HOGENOMiHOG000266084
InParanoidiP0ACS5
KOiK13638
OMAiCAVETIR
PhylomeDBiP0ACS5

Family and domain databases

InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
IPR011788 ZntR
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR02043 ZntR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRIGELAKM AEVTPDTIRY YEKQQMMEHE VRTEGGFRLY TESDLQRLKF
60 70 80 90 100
IRHARQLGFS LESIRELLSI RIDPEHHTCQ ESKGIVQERL QEVEARIAEL
110 120 130 140
QSMQRSLQRL NDACCGTAHS SVYCSILEAL EQGASGVKSG C
Length:141
Mass (Da):16,179
Last modified:November 22, 2005 - v1
Checksum:iEB451201C8BDCE20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29458 Genomic DNA Translation: AAA24773.1
U18997 Genomic DNA Translation: AAA58089.1
U00096 Genomic DNA Translation: AAC76317.1
AP009048 Genomic DNA Translation: BAE77999.1
PIRiI67892
RefSeqiNP_417751.1, NC_000913.3
WP_000285607.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76317; AAC76317; b3292
BAE77999; BAE77999; BAE77999
GeneIDi947786
KEGGiecj:JW3254
eco:b3292
PATRICifig|1411691.4.peg.3439

Similar proteinsi

Entry informationi

Entry nameiZNTR_ECOLI
AccessioniPrimary (citable) accession number: P0ACS5
Secondary accession number(s): P36676, Q2M6V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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