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Protein

Transcriptional repressor MprA

Gene

mprA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negative regulator of the multidrug operon emrAB.1 Publication

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to antibiotic Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG10603-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor MprA
Alternative name(s):
Protein EmrR
Gene namesi
Name:mprA
Synonyms:emrR
Ordered Locus Names:b2684, JW2659
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10603 mprA

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000543731 – 176Transcriptional repressor MprAAdd BLAST176

Proteomic databases

PaxDbiP0ACR9
PRIDEiP0ACR9

Expressioni

Inductioni

Autoregulated.

Interactioni

Protein-protein interaction databases

BioGridi4262945, 13 interactors
DIPiDIP-10248N
IntActiP0ACR9, 11 interactors
STRINGi316407.1800069

Structurei

3D structure databases

ProteinModelPortaliP0ACR9
SMRiP0ACR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 160HTH marR-typePROSITE-ProRule annotationAdd BLAST135

Phylogenomic databases

eggNOGiENOG4105NTK Bacteria
COG1846 LUCA
HOGENOMiHOG000117211
InParanoidiP0ACR9
KOiK15974
OMAiETYANID
PhylomeDBiP0ACR9

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000835 HTH_MarR-typ
IPR023187 Tscrpt_reg_MarR-type_CS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01047 MarR, 1 hit
PRINTSiPR00598 HTHMARR
SMARTiView protein in SMART
SM00347 HTH_MARR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS01117 HTH_MARR_1, 1 hit
PS50995 HTH_MARR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSFTPIEQ MLKFRASRHE DFPYQEILLT RLCMHMQSKL LENRNKMLKA
60 70 80 90 100
QGINETLFMA LITLESQENH SIQPSELSCA LGSSRTNATR IADELEKRGW
110 120 130 140 150
IERRESDNDR RCLHLQLTEK GHEFLREVLP PQHNCLHQLW SALSTTEKDQ
160 170
LEQITRKLLS RLDQMEQDGV VLEAMS
Length:176
Mass (Da):20,563
Last modified:November 22, 2005 - v1
Checksum:iBF4D3E34DAD0718A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54151 Genomic DNA Translation: CAA38090.1
U00096 Genomic DNA Translation: AAC75731.1
AP009048 Genomic DNA Translation: BAA16546.1
M86657 Genomic DNA No translation available.
U19993 Genomic DNA No translation available.
PIRiS14473
RefSeqiNP_417169.1, NC_000913.3
WP_000378442.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75731; AAC75731; b2684
BAA16546; BAA16546; BAA16546
GeneIDi945282
KEGGiecj:JW2659
eco:b2684
PATRICifig|1411691.4.peg.4056

Similar proteinsi

Entry informationi

Entry nameiMPRA_ECOLI
AccessioniPrimary (citable) accession number: P0ACR9
Secondary accession number(s): P24201, P77027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health