P0ACR2 (YDHB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized HTH-type transcriptional regulator YdhB

Gene names

Name:	ydhB
Ordered Locus Names:	b1659, JW1651

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities

Contains 1 HTH lysR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Uncharacterized HTH-type transcriptional regulator YdhB		PRO_0000105784
Regions
	Domain	1 – 59	59	HTH lysR-type
	DNA binding	19 – 38	20	H-T-H motif By similarity
Experimental info
	Sequence conflict	253	1	K → E Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P0ACR2 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: BBC7A2F2B2AC351A	FASTA	310	35,250
	10 20 30 40 50 60 MWSEYSLEVV DAVARNGSFS AAAQELHRVP SAVSYTVRQL EEWLAVPLFE RRHRDVELTA 70 80 90 100 110 120 AGAWFLKEGR SVVKKMQITR QQCQQIANGW RGQLAIAVDN IVRPERTRQM IVDFYRHFDD 130 140 150 160 170 180 VELLVFQEVF NGVWDALSDG RVELAIGATR AIPVGGRYAF RDMGMLSWSC VVASHHPLAL 190 200 210 220 230 240 MDGPFSDDTL RNWPSLVRED TSRTLPKRIT WLLDNQKRVV VPDWESSATC ISAGLCIGMV 250 260 270 280 290 300 PTHFAKPWLN EGKWVALELE NPFPDSACCL TWQQNDMSPA LTWLLEYLGD SETLNKEWLR 310 EPEETPATGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing, mapping and hyperexpression of the ribC gene coding for riboflavin synthase of Escherichia coli." Eberhardt S.M.R., Richter G., Gimbel W., Werner T., Bacher A. Eur. J. Biochem. 242:712-719(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / RR28.
[2]	"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. , Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T. DNA Res. 3:363-377(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 253. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Autoregulation of PurR repressor synthesis and involvement of purR in the regulation of purB, purC, purL, purMN and guaBA expression in Escherichia coli." Meng L.M., Kilstrup M., Nygaard P. Eur. J. Biochem. 187:373-379(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-310. Strain: K12.
[6]	Rudd K.E. Unpublished observations (FEB-1994) Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69109 Genomic DNA. No translation available. U00096 Genomic DNA. Translation: AAC74731.1. AP009048 Genomic DNA. Translation: BAA15425.2. X51368 Genomic DNA. No translation available.
PIR	E64923.
RefSeq	NP_416176.1. NC_000913.2. YP_489923.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0ACR2.
SMR	P0ACR2. Positions 6-148.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0ACR2. 5 interactions.
STRING	511145.b1659.
Proteomic databases
PaxDb	P0ACR2.
PRIDE	P0ACR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC74731; AAC74731; b1659. BAA15425; BAA15425; BAA15425.
GeneID	12933914. 945208.
KEGG	ecj:Y75_p1636. eco:b1659.
PATRIC	32118624. VBIEscCol129921_1732.
Organism-specific databases
EchoBASE	EB2061.
EcoGene	EG12140. ydhB.
Phylogenomic databases
eggNOG	COG0583.
HOGENOM	HOG000181313.
OMA	KLHKVPS.
ProtClustDB	PRK11074.
Enzyme and pathway databases
BioCyc	EcoCyc:EG12140-MONOMER. ECOL316407:JW1651-MONOMER.
Gene expression databases
Genevestigator	P0ACR2.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR005119. LysR_subst-bd. IPR000847. Tscrpt_reg_HTH_LysR. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00126. HTH_1. 1 hit. PF03466. LysR_substrate. 1 hit. [Graphical view]
PROSITE	PS50931. HTH_LYSR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YDHB_ECOLI

Accession

Primary (citable) accession number: P0ACR2
Secondary accession number(s): P37598, P77677

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program