Reviewed, UniProtKB/Swiss-Prot P0ACR0 (ALLS_ECOLI)

Names and origin

Protein names

Recommended name:
    HTH-type transcriptional activator allS

Gene names

Name:	allS
Synonyms:	glxA1, ybbS
Ordered Locus Names:	b0504, JW0492

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Positive regulator essential for the expression of allD operon. Binds to the allD promoter. Ref.5
Induction	Induced anaerobically and by nitrogen limitation. Repressed by allR. Ref.5
Sequence similarities	Contains 1 HTH lysR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	HTH-type transcriptional activator allS		PRO_0000105776
Regions
	Domain	2 – 59	58	HTH lysR-type
	DNA binding	19 – 38	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0ACR0-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 42A4727F078CE0B6	FASTA	308	34,512
	10 20 30 40 50 60 MFDPETLRTF IAVAETGSFS KAAERLCKTT ATISYRIKLL EENTGVALFF RTTRSVTLTA 70 80 90 100 110 120 AGEHLLSQAR DWLSWLESMP SELQQVNDGV ERQVNIVINN LLYNPQAVAQ LLAWLNERYP 130 140 150 160 170 180 FTQFHISRQI YMGVWDSLLY EGFSLAIGVT GTEALANTFS LDPLGSVQWR FVMAADHPLA 190 200 210 220 230 240 NVEEPLTEAQ LRRFPAVNIE DSARTLTKRV AWRLPGQKEI IVPDMETKIA AHLAGVGIGF 250 260 270 280 290 300 LPKSLCQSMI DNQQLVSRVI PTMRPPSPLS LAWRKFGSGK AVEDIVTLFT QRRPEISGFL EIFGNPRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli." Cusa E., Obradors N., Baldoma L., Badia J., Aguilar J. J. Bacteriol. 181:7479-7484(1999) [PubMed: 10601204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / ECL1.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Regulation of the Escherichia coli allantoin regulon: coordinated function of the repressor AllR and the activator AllS." Rintoul M.R., Cusa E., Baldoma L., Badia J., Reitzer L., Aguilar J. J. Mol. Biol. 324:599-610(2002) [PubMed: 12460564] [Abstract] Cited for: FUNCTION, DNA-BINDING, INDUCTION. Strain: K12.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U89024 Genomic DNA. Translation: AAB93845.1. U82664 Genomic DNA. Translation: AAB40257.1. U00096 Genomic DNA. Translation: AAC73606.1. AP009048 Genomic DNA. Translation: BAE76282.1.
PIR	G64781.
RefSeq	AP_001152.1. NP_415037.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	945139.
GenomeReviews	Gene locus JW0492 in contig AP009048_GR. Gene locus b0504 in contig U00096_GR.
KEGG	ecj:JW0492. eco:b0504.
Organism-specific databases
EchoBASE	EB3053.
EcoGene	EG13267. allS.
CMR	Search...
Phylogenomic databases
HOGENOM	P0ACR0.
OMA	P0ACR0. WLSWLSW.
Enzyme and pathway databases
BioCyc	EcoCyc:G6274-MON.
Family and domain databases
InterPro	IPR000847. HTH_LysR. IPR005119. LysR_subst_bd. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00126. HTH_1. 1 hit. PF03466. LysR_substrate. 1 hit. [Graphical view]
PROSITE	PS50931. HTH_LYSR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALLS_ECOLI

Accession

Primary (citable) accession number: P0ACR0
Secondary accession number(s): P77702, Q2MBS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)