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Protein

HTH-type transcriptional regulator TdcA

Gene

tdcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional activator for the tdcABCDE operon.1 Publication

Pathwayi: L-threonine degradation via propanoate pathway

This protein regulates the pathway L-threonine degradation via propanoate pathway, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-threonine degradation via propanoate pathway and in Amino-acid degradation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi24 – 4320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • L-threonine catabolic process to propionate Source: UniProtKB-UniPathway
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00268.
ECOL316407:JW3089-MONOMER.
UniPathwayiUPA00052.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator TdcA
Alternative name(s):
Tdc operon transcriptional activator
Gene namesi
Name:tdcA
Ordered Locus Names:b3118, JW3089
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10989. tdcA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoCyc
  • cytosol Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312HTH-type transcriptional regulator TdcAPRO_0000105757Add
BLAST

Proteomic databases

PaxDbiP0ACQ7.

Interactioni

Protein-protein interaction databases

BioGridi4262420. 7 interactions.
DIPiDIP-10968N.
IntActiP0ACQ7. 3 interactions.
MINTiMINT-1310858.
STRINGi511145.b3118.

Structurei

3D structure databases

ProteinModelPortaliP0ACQ7.
SMRiP0ACQ7. Positions 6-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6458HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410811B. Bacteria.
ENOG410XW1S. LUCA.
HOGENOMiHOG000233526.
KOiK07592.
OMAiPWPLIES.
OrthoDBiEOG6V7BJ7.
PhylomeDBiP0ACQ7.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTILLPKTQ HLVVFQEVIR SGSIGSAAKE LGLTQPAVSK IINDIEDYFG
60 70 80 90 100
VELVVRKNTG VTLTPAGQLL LSRSESITRE MKNMVNEISG MSSEAVVEVS
110 120 130 140 150
FGFPSLIGFT FMSGMINKFK EVFPKAQVSM YEAQLSSFLP AIRDGRLDFA
160 170 180 190 200
IGTLSAEMKL QDLHVEPLFE SEFVLVASKS RTCTGTTTLE SLKNEQWVLP
210 220 230 240 250
QTNMGYYSEL LTTLQRNGIS IENIVKTDSV VTIYNLVLNA DFLTVIPCDM
260 270 280 290 300
TSPFGSNQFI TIPVEETLPV AQYAAVWSKN YRIKKAASVL VELAKEYSSY
310
NGCRRRQLIE VG
Length:312
Mass (Da):34,539
Last modified:November 22, 2005 - v1
Checksum:i1ADD366D71ED68AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31T → A in AAA24659 (PubMed:3003533).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21312 Genomic DNA. Translation: AAA24659.1.
X14430 Genomic DNA. Translation: CAA32592.1.
U18997 Genomic DNA. Translation: AAA57922.1.
U00096 Genomic DNA. Translation: AAC76153.1.
AP009048 Genomic DNA. Translation: BAE77167.1.
AJ001620 Genomic DNA. Translation: CAA04873.1.
PIRiS46415. QQECRG.
RefSeqiNP_417588.1. NC_000913.3.
WP_000104211.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76153; AAC76153; b3118.
BAE77167; BAE77167; BAE77167.
GeneIDi947494.
KEGGiecj:JW3089.
eco:b3118.
PATRICi32121652. VBIEscCol129921_3212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21312 Genomic DNA. Translation: AAA24659.1.
X14430 Genomic DNA. Translation: CAA32592.1.
U18997 Genomic DNA. Translation: AAA57922.1.
U00096 Genomic DNA. Translation: AAC76153.1.
AP009048 Genomic DNA. Translation: BAE77167.1.
AJ001620 Genomic DNA. Translation: CAA04873.1.
PIRiS46415. QQECRG.
RefSeqiNP_417588.1. NC_000913.3.
WP_000104211.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACQ7.
SMRiP0ACQ7. Positions 6-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262420. 7 interactions.
DIPiDIP-10968N.
IntActiP0ACQ7. 3 interactions.
MINTiMINT-1310858.
STRINGi511145.b3118.

Proteomic databases

PaxDbiP0ACQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76153; AAC76153; b3118.
BAE77167; BAE77167; BAE77167.
GeneIDi947494.
KEGGiecj:JW3089.
eco:b3118.
PATRICi32121652. VBIEscCol129921_3212.

Organism-specific databases

EchoBASEiEB0982.
EcoGeneiEG10989. tdcA.

Phylogenomic databases

eggNOGiENOG410811B. Bacteria.
ENOG410XW1S. LUCA.
HOGENOMiHOG000233526.
KOiK07592.
OMAiPWPLIES.
OrthoDBiEOG6V7BJ7.
PhylomeDBiP0ACQ7.

Enzyme and pathway databases

UniPathwayiUPA00052.
BioCyciEcoCyc:PD00268.
ECOL316407:JW3089-MONOMER.

Miscellaneous databases

PROiP0ACQ7.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of the biodegradative threonine dehydratase gene (tdc) of Escherichia coli K12."
    Goss T.J., Datta P.
    Mol. Gen. Genet. 201:308-314(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete nucleotide sequence of the tdc region of Escherichia coli."
    Schweizer H., Datta P.
    Nucleic Acids Res. 17:3994-3994(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The tdcE gene in Escherichia coli strain W3110 is separated from the rest of the tdc operon by insertion of IS5 elements."
    Hesslinger C., Sawers G.
    DNA Seq. 9:183-188(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 159-215.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "TdcA, a transcriptional activator of the tdcABC operon of Escherichia coli, is a member of the LysR family of proteins."
    Ganduri Y.L., Sadda S.R., Datta M.W., Jambukeswaran R.K., Datta P.
    Mol. Gen. Genet. 240:395-402(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTDCA_ECOLI
AccessioniPrimary (citable) accession number: P0ACQ7
Secondary accession number(s): P11036, Q2M989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.