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Protein

Ribose operon repressor

Gene

rbsR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor for the ribose rbsDACBK operon. RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional start site. The affinity for the rbs operator is reduced by addition of ribose, consistent with ribose being the inducer of the operon.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi4 – 2320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD03867.
ECOL316407:JW3732-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose operon repressor
Gene namesi
Name:rbsR
Ordered Locus Names:b3753, JW3732
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10819. rbsR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 330329Ribose operon repressorPRO_0000107985Add
BLAST

Proteomic databases

PaxDbiP0ACQ0.
PRIDEiP0ACQ0.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mqsAQ468643EBI-1119646,EBI-1120353

Protein-protein interaction databases

BioGridi4261326. 7 interactions.
IntActiP0ACQ0. 5 interactions.
STRINGi511145.b3753.

Structurei

3D structure databases

ProteinModelPortaliP0ACQ0.
SMRiP0ACQ0. Positions 1-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 5655HTH lacI-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220180.
InParanoidiP0ACQ0.
KOiK02529.
OMAiERCCYER.
PhylomeDBiP0ACQ0.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ACQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMKDVARL AGVSTSTVSH VINKDRFVSE AITAKVEAAI KELNYAPSAL
60 70 80 90 100
ARSLKLNQTH TIGMLITAST NPFYSELVRG VERSCFERGY SLVLCNTEGD
110 120 130 140 150
EQRMNRNLET LMQKRVDGLL LLCTETHQPS REIMQRYPTV PTVMMDWAPF
160 170 180 190 200
DGDSDLIQDN SLLGGDLATQ YLIDKGHTRI ACITGPLDKT PARLRLEGYR
210 220 230 240 250
AAMKRAGLNI PDGYEVTGDF EFNGGFDAMR QLLSHPLRPQ AVFTGNDAMA
260 270 280 290 300
VGVYQALYQA ELQVPQDIAV IGYDDIELAS FMTPPLTTIH QPKDELGELA
310 320 330
IDVLIHRITQ PTLQQQRLQL TPILMERGSA
Length:330
Mass (Da):36,612
Last modified:January 23, 2007 - v2
Checksum:iAA651205A4109CAE
GO

Sequence cautioni

The sequence AAA62106 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 132GV → L in AAA51477 (PubMed:1304369).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13169 Genomic DNA. Translation: AAA51477.1.
D10466 Genomic DNA. Translation: BAA01259.1.
L10328 Genomic DNA. Translation: AAA62106.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76776.1.
AP009048 Genomic DNA. Translation: BAE77535.1.
PIRiB65179.
RefSeqiNP_418209.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76776; AAC76776; b3753.
BAE77535; BAE77535; BAE77535.
GeneIDi948266.
KEGGiecj:JW3732.
eco:b3753.
PATRICi32123005. VBIEscCol129921_3878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13169 Genomic DNA. Translation: AAA51477.1.
D10466 Genomic DNA. Translation: BAA01259.1.
L10328 Genomic DNA. Translation: AAA62106.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76776.1.
AP009048 Genomic DNA. Translation: BAE77535.1.
PIRiB65179.
RefSeqiNP_418209.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0ACQ0.
SMRiP0ACQ0. Positions 1-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261326. 7 interactions.
IntActiP0ACQ0. 5 interactions.
STRINGi511145.b3753.

Proteomic databases

PaxDbiP0ACQ0.
PRIDEiP0ACQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76776; AAC76776; b3753.
BAE77535; BAE77535; BAE77535.
GeneIDi948266.
KEGGiecj:JW3732.
eco:b3753.
PATRICi32123005. VBIEscCol129921_3878.

Organism-specific databases

EchoBASEiEB0812.
EcoGeneiEG10819. rbsR.

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220180.
InParanoidiP0ACQ0.
KOiK02529.
OMAiERCCYER.
PhylomeDBiP0ACQ0.

Enzyme and pathway databases

BioCyciEcoCyc:PD03867.
ECOL316407:JW3732-MONOMER.

Miscellaneous databases

PROiP0ACQ0.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBSR_ECOLI
AccessioniPrimary (citable) accession number: P0ACQ0
Secondary accession number(s): P25551, Q2M871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.