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Protein

Ribose operon repressor

Gene

rbsR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor for the ribose rbsDACBK operon. RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional start site. The affinity for the rbs operator is reduced by addition of ribose, consistent with ribose being the inducer of the operon.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD03867

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose operon repressor
Gene namesi
Name:rbsR
Ordered Locus Names:b3753, JW3732
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10819 rbsR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001079852 – 330Ribose operon repressorAdd BLAST329

Proteomic databases

PaxDbiP0ACQ0
PRIDEiP0ACQ0

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mqsAQ468643EBI-1119646,EBI-1120353

Protein-protein interaction databases

BioGridi4261326, 10 interactors
IntActiP0ACQ0, 5 interactors
STRINGi316407.85676285

Structurei

3D structure databases

ProteinModelPortaliP0ACQ0
SMRiP0ACQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 56HTH lacI-typePROSITE-ProRule annotationAdd BLAST55

Phylogenomic databases

eggNOGiENOG4105ETE Bacteria
COG1609 LUCA
HOGENOMiHOG000220180
InParanoidiP0ACQ0
KOiK02529
OMAiIMQRYPS
PhylomeDBiP0ACQ0

Family and domain databases

CDDicd01392 HTH_LacI, 1 hit
InterProiView protein in InterPro
IPR000843 HTH_LacI
IPR010982 Lambda_DNA-bd_dom_sf
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00356 LacI, 1 hit
PRINTSiPR00036 HTHLACI
SMARTiView protein in SMART
SM00354 HTH_LACI, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
SSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00356 HTH_LACI_1, 1 hit
PS50932 HTH_LACI_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ACQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMKDVARL AGVSTSTVSH VINKDRFVSE AITAKVEAAI KELNYAPSAL
60 70 80 90 100
ARSLKLNQTH TIGMLITAST NPFYSELVRG VERSCFERGY SLVLCNTEGD
110 120 130 140 150
EQRMNRNLET LMQKRVDGLL LLCTETHQPS REIMQRYPTV PTVMMDWAPF
160 170 180 190 200
DGDSDLIQDN SLLGGDLATQ YLIDKGHTRI ACITGPLDKT PARLRLEGYR
210 220 230 240 250
AAMKRAGLNI PDGYEVTGDF EFNGGFDAMR QLLSHPLRPQ AVFTGNDAMA
260 270 280 290 300
VGVYQALYQA ELQVPQDIAV IGYDDIELAS FMTPPLTTIH QPKDELGELA
310 320 330
IDVLIHRITQ PTLQQQRLQL TPILMERGSA
Length:330
Mass (Da):36,612
Last modified:January 23, 2007 - v2
Checksum:iAA651205A4109CAE
GO

Sequence cautioni

The sequence AAA62106 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13GV → L in AAA51477 (PubMed:1304369).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13169 Genomic DNA Translation: AAA51477.1
D10466 Genomic DNA Translation: BAA01259.1
L10328 Genomic DNA Translation: AAA62106.1 Different initiation.
U00096 Genomic DNA Translation: AAC76776.1
AP009048 Genomic DNA Translation: BAE77535.1
PIRiB65179
RefSeqiNP_418209.1, NC_000913.3
WP_000224470.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76776; AAC76776; b3753
BAE77535; BAE77535; BAE77535
GeneIDi948266
KEGGiecj:JW3732
eco:b3753
PATRICifig|1411691.4.peg.2947

Similar proteinsi

Entry informationi

Entry nameiRBSR_ECOLI
AccessioniPrimary (citable) accession number: P0ACQ0
Secondary accession number(s): P25551, Q2M871
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health