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Protein

HTH-type transcriptional regulator GntR

Gene

gntR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon.

Pathwayi: D-gluconate degradation

This protein regulates the pathway D-gluconate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway D-gluconate degradation and in Carbohydrate acid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 27H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • D-gluconate catabolic process Source: UniProtKB-UniPathway
  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD03585
UniPathwayiUPA00792

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GntR
Alternative name(s):
Gluconate utilization system GNT-I transcriptional repressor
Gene namesi
Name:gntR
Ordered Locus Names:b3438, JW5946
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12630 gntR

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079581 – 331HTH-type transcriptional regulator GntRAdd BLAST331

Proteomic databases

PaxDbiP0ACP5
PRIDEiP0ACP5

Interactioni

Protein-protein interaction databases

BioGridi4259299, 18 interactors
DIPiDIP-9822N
STRINGi316385.ECDH10B_3611

Structurei

3D structure databases

ProteinModelPortaliP0ACP5
SMRiP0ACP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 60HTH lacI-typePROSITE-ProRule annotationAdd BLAST55

Phylogenomic databases

eggNOGiENOG4105DIQ Bacteria
ENOG410XPSF LUCA
HOGENOMiHOG000220181
InParanoidiP0ACP5
KOiK06145
OMAiCVHMMEL
PhylomeDBiP0ACP5

Family and domain databases

CDDicd01392 HTH_LacI, 1 hit
InterProiView protein in InterPro
IPR000843 HTH_LacI
IPR010982 Lambda_DNA-bd_dom_sf
IPR001761 Peripla_BP/Lac1_sug-bd_dom
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00356 LacI, 1 hit
PF00532 Peripla_BP_1, 1 hit
SMARTiView protein in SMART
SM00354 HTH_LACI, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
SSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00356 HTH_LACI_1, 1 hit
PS50932 HTH_LACI_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKRPVLQD VADRVGVTKM TVSRFLRNPE QVSVALRGKI AAALDELGYI
60 70 80 90 100
PNRAPDILSN ATSRAIGVLL PSLTNQVFAE VLRGIESVTD AHGYQTMLAH
110 120 130 140 150
YGYKPEMEQE RLESMLSWNI DGLILTERTH TPRTLKMIEV AGIPVVELMD
160 170 180 190 200
SKSPCLDIAV GFDNFEAARQ MTTAIIARGH RHIAYLGARL DERTIIKQKG
210 220 230 240 250
YEQAMLDAGL VPYSVMVEQS SSYSSGIELI RQARREYPQL DGVFCTNDDL
260 270 280 290 300
AVGAAFECQR LGLKVPDDMA IAGFHGHDIG QVMEPRLASV LTPRERMGSI
310 320 330
GAERLLARIR GESVTPKMLD LGFTLSPGGS I
Length:331
Mass (Da):36,422
Last modified:November 22, 2005 - v1
Checksum:i5A40666364E0C896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84362 Genomic DNA Translation: BAA12324.1
U18997 Genomic DNA Translation: AAA58236.1
U00096 Genomic DNA Translation: AAT48184.1
AP009048 Genomic DNA Translation: BAE77855.1
PIRiA65140
RefSeqiWP_000730252.1, NZ_LN832404.1
YP_026222.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48184; AAT48184; b3438
BAE77855; BAE77855; BAE77855
GeneIDi947946
KEGGiecj:JW5946
eco:b3438
PATRICifig|1411691.4.peg.3291

Similar proteinsi

Entry informationi

Entry nameiGNTR_ECOLI
AccessioniPrimary (citable) accession number: P0ACP5
Secondary accession number(s): P46860, Q2M7A1, Q47241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health