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Protein

HTH-type transcriptional regulator GntR

Gene

gntR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon.

Pathwayi: D-gluconate degradation

This protein regulates the pathway D-gluconate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway D-gluconate degradation and in Carbohydrate acid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 27H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • D-gluconate catabolic process Source: UniProtKB-UniPathway
  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD03585.
UniPathwayiUPA00792.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GntR
Alternative name(s):
Gluconate utilization system GNT-I transcriptional repressor
Gene namesi
Name:gntR
Ordered Locus Names:b3438, JW5946
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12630. gntR.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079581 – 331HTH-type transcriptional regulator GntRAdd BLAST331

Proteomic databases

PaxDbiP0ACP5.
PRIDEiP0ACP5.

Interactioni

Protein-protein interaction databases

BioGridi4259299. 13 interactors.
DIPiDIP-9822N.
STRINGi511145.b3438.

Structurei

3D structure databases

ProteinModelPortaliP0ACP5.
SMRiP0ACP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 60HTH lacI-typePROSITE-ProRule annotationAdd BLAST55

Phylogenomic databases

eggNOGiENOG4105DIQ. Bacteria.
ENOG410XPSF. LUCA.
HOGENOMiHOG000220181.
InParanoidiP0ACP5.
KOiK06145.
OMAiMESIVAH.
PhylomeDBiP0ACP5.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiView protein in InterPro
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR001761. Peripla_BP/Lac1_sug-bd_dom.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00356. LacI. 1 hit.
PF00532. Peripla_BP_1. 1 hit.
SMARTiView protein in SMART
SM00354. HTH_LACI. 1 hit.
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKRPVLQD VADRVGVTKM TVSRFLRNPE QVSVALRGKI AAALDELGYI
60 70 80 90 100
PNRAPDILSN ATSRAIGVLL PSLTNQVFAE VLRGIESVTD AHGYQTMLAH
110 120 130 140 150
YGYKPEMEQE RLESMLSWNI DGLILTERTH TPRTLKMIEV AGIPVVELMD
160 170 180 190 200
SKSPCLDIAV GFDNFEAARQ MTTAIIARGH RHIAYLGARL DERTIIKQKG
210 220 230 240 250
YEQAMLDAGL VPYSVMVEQS SSYSSGIELI RQARREYPQL DGVFCTNDDL
260 270 280 290 300
AVGAAFECQR LGLKVPDDMA IAGFHGHDIG QVMEPRLASV LTPRERMGSI
310 320 330
GAERLLARIR GESVTPKMLD LGFTLSPGGS I
Length:331
Mass (Da):36,422
Last modified:November 22, 2005 - v1
Checksum:i5A40666364E0C896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84362 Genomic DNA. Translation: BAA12324.1.
U18997 Genomic DNA. Translation: AAA58236.1.
U00096 Genomic DNA. Translation: AAT48184.1.
AP009048 Genomic DNA. Translation: BAE77855.1.
PIRiA65140.
RefSeqiWP_000730252.1. NZ_LN832404.1.
YP_026222.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48184; AAT48184; b3438.
BAE77855; BAE77855; BAE77855.
GeneIDi947946.
KEGGiecj:JW5946.
eco:b3438.
PATRICi32122314. VBIEscCol129921_3534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84362 Genomic DNA. Translation: BAA12324.1.
U18997 Genomic DNA. Translation: AAA58236.1.
U00096 Genomic DNA. Translation: AAT48184.1.
AP009048 Genomic DNA. Translation: BAE77855.1.
PIRiA65140.
RefSeqiWP_000730252.1. NZ_LN832404.1.
YP_026222.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0ACP5.
SMRiP0ACP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259299. 13 interactors.
DIPiDIP-9822N.
STRINGi511145.b3438.

Proteomic databases

PaxDbiP0ACP5.
PRIDEiP0ACP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48184; AAT48184; b3438.
BAE77855; BAE77855; BAE77855.
GeneIDi947946.
KEGGiecj:JW5946.
eco:b3438.
PATRICi32122314. VBIEscCol129921_3534.

Organism-specific databases

EchoBASEiEB2514.
EcoGeneiEG12630. gntR.

Phylogenomic databases

eggNOGiENOG4105DIQ. Bacteria.
ENOG410XPSF. LUCA.
HOGENOMiHOG000220181.
InParanoidiP0ACP5.
KOiK06145.
OMAiMESIVAH.
PhylomeDBiP0ACP5.

Enzyme and pathway databases

UniPathwayiUPA00792.
BioCyciEcoCyc:PD03585.

Miscellaneous databases

PROiPR:P0ACP5.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiView protein in InterPro
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR001761. Peripla_BP/Lac1_sug-bd_dom.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00356. LacI. 1 hit.
PF00532. Peripla_BP_1. 1 hit.
SMARTiView protein in SMART
SM00354. HTH_LACI. 1 hit.
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGNTR_ECOLI
AccessioniPrimary (citable) accession number: P0ACP5
Secondary accession number(s): P46860, Q2M7A1, Q47241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 15, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.