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Protein

HTH-type transcriptional repressor CytR

Gene

cytR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi12 – 31H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • transcription regulatory region sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD04028.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor CytR
Gene namesi
Name:cytR
Ordered Locus Names:b3934, JW3905
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10200. cytR.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079381 – 341HTH-type transcriptional repressor CytRAdd BLAST341

Proteomic databases

PaxDbiP0ACN7.
PRIDEiP0ACN7.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
manXP697972EBI-1125696,EBI-554089

Protein-protein interaction databases

BioGridi4262650. 13 interactors.
DIPiDIP-9390N.
IntActiP0ACN7. 6 interactors.
STRINGi316385.ECDH10B_4123.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 18Combined sources7
Helixi23 – 29Combined sources7
Helixi38 – 50Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LCVNMR-A1-67[»]
ProteinModelPortaliP0ACN7.
SMRiP0ACN7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACN7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 64HTH lacI-typePROSITE-ProRule annotationAdd BLAST55

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220180.
InParanoidiP0ACN7.
KOiK05499.
PhylomeDBiP0ACN7.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
InterProiView protein in InterPro
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00356. LacI. 1 hit.
SMARTiView protein in SMART
SM00354. HTH_LACI. 1 hit.
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKKQETAA TMKDVALKAK VSTATVSRAL MNPDKVSQAT RNRVEKAARE
60 70 80 90 100
VGYLPQPMGR NVKRNESRTI LVIVPDICDP FFSEIIRGIE VTAANHGYLV
110 120 130 140 150
LIGDCAHQNQ QEKTFIDLII TKQIDGMLLL GSRLPFDASI EEQRNLPPMV
160 170 180 190 200
MANEFAPELE LPTVHIDNLT AAFDAVNYLY EQGHKRIGCI AGPEEMPLCH
210 220 230 240 250
YRLQGYVQAL RRCGIMVDPQ YIARGDFTFE AGSKAMQQLL DLPQPPTAVF
260 270 280 290 300
CHSDVMALGA LSQAKRQGLK VPEDLSIIGF DNIDLTQFCD PPLTTIAQPR
310 320 330 340
YEIGREAMLL LLDQMQGQHV GSGSRLMDCE LIIRGSTRAL P
Length:341
Mass (Da):37,820
Last modified:April 1, 1988 - v1
Checksum:i0C29D8829AE7062C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03683 Genomic DNA. Translation: CAA27318.1.
L19201 Genomic DNA. Translation: AAB03066.1.
U00096 Genomic DNA. Translation: AAC76916.1.
AP009048 Genomic DNA. Translation: BAE77376.1.
M33293 Genomic DNA. Translation: AAA24417.1.
PIRiA24963. RPECCT.
RefSeqiNP_418369.1. NC_000913.3.
WP_000644904.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76916; AAC76916; b3934.
BAE77376; BAE77376; BAE77376.
GeneIDi948427.
KEGGiecj:JW3905.
eco:b3934.
PATRICifig|1411691.4.peg.2771.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCYTR_ECOLI
AccessioniPrimary (citable) accession number: P0ACN7
Secondary accession number(s): P06964, Q2M8N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: July 5, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references