P0ACN6 (ALLR_ECO57) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional repressor AllR

Alternative name(s):
Negative regulator of allantoin and glyoxylate utilization operons

Gene names

Name:	allR
Ordered Locus Names:	Z0660, ECs0567

Organism

Escherichia coli O157:H7 [Complete proteome] [HAMAP]

Taxonomic identifier

83334 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergenic region By similarity.
Sequence similarities	Contains 1 HTH iclR-type DNA-binding domain. Contains 1 iclR-ED (iclR effector binding) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	HTH-type transcriptional repressor AllR		PRO_0000201754
Regions
	Domain	21 – 83	63	HTH iclR-type
	Domain	98 – 267	170	IclR-ED
	DNA binding	43 – 62	20	H-T-H motif Potential
	Region	154 – 156	3	Glyoxylate binding By similarity
	Region	234 – 236	3	Glyoxylate binding By similarity
Sites
	Binding site	207	1	Glyoxylate By similarity
	Binding site	217	1	Glyoxylate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0ACN6 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 476F59EEC0F8308B	FASTA	271	29,270
	10 20 30 40 50 60 MTEVRRRGRP GQAEPVAQKG AQALERGIAI LQYLEKSGGS SSVSDISLNL DLPLSTTFRL 70 80 90 100 110 120 LKVLQAADFV YQDSQLGWWH IGLGVFNVGA AYIHNRDVLS VAGPFMRRLM LLSGETVNVA 130 140 150 160 170 180 IRNGNEAVLI GQLECKSMVR MCAPLGSRLP LHASGAGKAL LYPLAEEELM SIILQTGLQQ 190 200 210 220 230 240 FTPTTLVDMP TLLKDLEQAR ELGYTVDKEE HVVGLNCIAS AIYDDVGSVV AAISISGPSS 250 260 270 RLTEDRFVSQ GELVRDTARD ISTALGLKAH P

References

[1]

"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R. Nature 409:529-533(2001) [PubMed: 11206551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.

[2]

"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. , Kuhara S., Shiba T., Hattori M., Shinagawa H. DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005174 Genomic DNA. Translation: AAG54862.1. BA000007 Genomic DNA. Translation: BAB33990.1.
PIR	B85550. G90699.
RefSeq	NP_286254.1. NC_002655.2. NP_308594.1. NC_002695.1.
3D structure databases
ProteinModelPortal	P0ACN6.
SMR	P0ACN6. Positions 12-269.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000025332; EBESCP00000024225; EBESCG00000024386. EBESCT00000057272; EBESCP00000055100; EBESCG00000056320.
GeneID	915706. 957496.
GenomeReviews	Gene locus Z0660 in contig AE005174_GR. Gene locus ECs0567 in contig BA000007_GR.
KEGG	ece:Z0660. ecs:ECs0567.
PATRIC	18350113. VBIEscCol44059_0577.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000008790.
HOGENOM	HBG739407.
OMA	VFRILAT.
ProtClustDB	PRK10163.
Enzyme and pathway databases
BioCyc	ECOL83334:ECS0567-MONOMER.
Family and domain databases
InterPro	IPR014757. Tscrpt_reg_IclR_C. IPR005471. Tscrpt_reg_IclR_N. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KO	K10973.
Pfam	PF09339. HTH_IclR. 1 hit. PF01614. IclR. 1 hit. [Graphical view]
SMART	SM00346. HTH_ICLR. 1 hit. [Graphical view]
PROSITE	PS51077. HTH_ICLR. 1 hit. PS51078. ICLR_ED. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P0ACN6.

Entry information

Entry name

ALLR_ECO57

Accession

Primary (citable) accession number: P0ACN6
Secondary accession number(s): P77734

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program