P0ACN5 (ALLR_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional repressor AllR

Alternative name(s):
Negative regulator of allantoin and glyoxylate utilization operons

Gene names

Name:	allR
Ordered Locus Names:	c0621

Organism

Escherichia coli O6 [Complete proteome] [HAMAP]

Taxonomic identifier

217992 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergenic region By similarity.
Sequence similarities	Contains 1 HTH iclR-type DNA-binding domain. Contains 1 iclR-ED (iclR effector binding) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	HTH-type transcriptional repressor AllR		PRO_0000201755
Regions
	Domain	21 – 83	63	HTH iclR-type
	Domain	98 – 267	170	IclR-ED
	DNA binding	43 – 62	20	H-T-H motif Potential
	Region	154 – 156	3	Glyoxylate binding By similarity
	Region	234 – 236	3	Glyoxylate binding By similarity
Sites
	Binding site	207	1	Glyoxylate By similarity
	Binding site	217	1	Glyoxylate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0ACN5 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 476F59EEC0F8308B	FASTA	271	29,270
	10 20 30 40 50 60 MTEVRRRGRP GQAEPVAQKG AQALERGIAI LQYLEKSGGS SSVSDISLNL DLPLSTTFRL 70 80 90 100 110 120 LKVLQAADFV YQDSQLGWWH IGLGVFNVGA AYIHNRDVLS VAGPFMRRLM LLSGETVNVA 130 140 150 160 170 180 IRNGNEAVLI GQLECKSMVR MCAPLGSRLP LHASGAGKAL LYPLAEEELM SIILQTGLQQ 190 200 210 220 230 240 FTPTTLVDMP TLLKDLEQAR ELGYTVDKEE HVVGLNCIAS AIYDDVGSVV AAISISGPSS 250 260 270 RLTEDRFVSQ GELVRDTARD ISTALGLKAH P

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014075 Genomic DNA. Translation: AAN79098.1.
RefSeq	NP_752554.1. NC_004431.1.
3D structure databases
ProteinModelPortal	P0ACN5.
SMR	P0ACN5. Positions 12-269.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000040705; EBESCP00000039054; EBESCG00000039755.
GeneID	1036274.
GenomeReviews	Gene locus c0621 in contig AE014075_GR.
KEGG	ecc:c0621.
PATRIC	18279285. VBIEscCol75197_0587.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000008790.
HOGENOM	HBG739407.
OMA	VFRILAT.
ProtClustDB	PRK10163.
Family and domain databases
InterPro	IPR014757. Tscrpt_reg_IclR_C. IPR005471. Tscrpt_reg_IclR_N. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KO	K10973.
Pfam	PF09339. HTH_IclR. 1 hit. PF01614. IclR. 1 hit. [Graphical view]
SMART	SM00346. HTH_ICLR. 1 hit. [Graphical view]
PROSITE	PS51077. HTH_ICLR. 1 hit. PS51078. ICLR_ED. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P0ACN5.

Entry information

Entry name

ALLR_ECOL6

Accession

Primary (citable) accession number: P0ACN5
Secondary accession number(s): P77734

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program