ID   YEGW_ECOLI              Reviewed;         248 AA.
AC   P0ACM5; O08014; P76420;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   27-MAR-2024, entry version 122.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator YegW;
GN   Name=yegW; OrderedLocusNames=b2101, JW2088;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA   Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA   Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA   Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA   Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA   Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA   Horiuchi T.;
RT   "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 40.1-50.0 min region on the linkage map.";
RL   DNA Res. 3:379-392(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
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DR   EMBL; U00096; AAC75162.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15969.1; -; Genomic_DNA.
DR   PIR; D64977; D64977.
DR   RefSeq; NP_416604.1; NC_000913.3.
DR   RefSeq; WP_000434038.1; NZ_STEB01000002.1.
DR   AlphaFoldDB; P0ACM5; -.
DR   SMR; P0ACM5; -.
DR   BioGRID; 4261161; 125.
DR   DIP; DIP-11893N; -.
DR   IntAct; P0ACM5; 2.
DR   STRING; 511145.b2101; -.
DR   jPOST; P0ACM5; -.
DR   PaxDb; 511145-b2101; -.
DR   EnsemblBacteria; AAC75162; AAC75162; b2101.
DR   GeneID; 75205963; -.
DR   GeneID; 946639; -.
DR   KEGG; ecj:JW2088; -.
DR   KEGG; eco:b2101; -.
DR   PATRIC; fig|1411691.4.peg.146; -.
DR   EchoBASE; EB3819; -.
DR   eggNOG; COG2188; Bacteria.
DR   HOGENOM; CLU_063236_4_0_6; -.
DR   InParanoid; P0ACM5; -.
DR   OMA; QTGVALW; -.
DR   OrthoDB; 6626198at2; -.
DR   PhylomeDB; P0ACM5; -.
DR   BioCyc; EcoCyc:G7133-MONOMER; -.
DR   PRO; PR:P0ACM5; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 3.40.1410.10; Chorismate lyase-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR44846; MANNOSYL-D-GLYCERATE TRANSPORT/METABOLISM SYSTEM REPRESSOR MNGR-RELATED; 1.
DR   PANTHER; PTHR44846:SF1; MANNOSYL-D-GLYCERATE TRANSPORT_METABOLISM SYSTEM REPRESSOR MNGR; 1.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF64288; Chorismate lyase-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..248
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   YegW"
FT                   /id="PRO_0000050676"
FT   DOMAIN          22..90
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        50..69
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   248 AA;  28277 MW;  E4B3CD729CA7F1C8 CRC64;
     MEQAHTQLIA QLNERILAAD NTPLYIKFAE TVKNAVRSGV LEHGNILPGE RDLSQLTGVS
     RITVRKAMQA LEEEGVVTRS RGYGTQINNI FEYSLKEARG FSQQVVLRGK KPDTLWVNKR
     VVKCPEEVAQ QLAVEAGSDV FLLKRIRYVD EEAVSIEESW VPAHLIHDVD AIGISLYDYF
     RSQHIYPQRT RSRVSARMPD AEFQSHIQLD SKIPVLVIKQ VALDQQQRPI EYSISHCRSD
     LYVFVCEE
//