P0ACM5 (YEGW_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized HTH-type transcriptional regulator YegW

Gene names

Name:	yegW
Ordered Locus Names:	b2101, JW2088

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 HTH gntR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
xapR	P23841	1	EBI-1120686,EBI-1127539

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Uncharacterized HTH-type transcriptional regulator YegW		PRO_0000050676
Regions
	Domain	22 – 90	69	HTH gntR-type
	DNA binding	50 – 69	20	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	P0ACM5 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: E4B3CD729CA7F1C8	FASTA	248	28,277
	10 20 30 40 50 60 MEQAHTQLIA QLNERILAAD NTPLYIKFAE TVKNAVRSGV LEHGNILPGE RDLSQLTGVS 70 80 90 100 110 120 RITVRKAMQA LEEEGVVTRS RGYGTQINNI FEYSLKEARG FSQQVVLRGK KPDTLWVNKR 130 140 150 160 170 180 VVKCPEEVAQ QLAVEAGSDV FLLKRIRYVD EEAVSIEESW VPAHLIHDVD AIGISLYDYF 190 200 210 220 230 240 RSQHIYPQRT RSRVSARMPD AEFQSHIQLD SKIPVLVIKQ VALDQQQRPI EYSISHCRSD LYVFVCEE

References

[1]	"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T. DNA Res. 3:379-392(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC75162.1. AP009048 Genomic DNA. Translation: BAA15969.1.
PIR	D64977.
RefSeq	NP_416604.1. NC_000913.2. YP_490341.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0ACM5.
SMR	P0ACM5. Positions 16-245.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0ACM5. 2 interactions.
STRING	511145.b2101.
Proteomic databases
PRIDE	P0ACM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75162; AAC75162; b2101. BAA15969; BAA15969; BAA15969.
GeneID	12932167. 946639.
KEGG	ecj:Y75_p2063. eco:b2101.
PATRIC	32119535. VBIEscCol129921_2178.
Organism-specific databases
EchoBASE	EB3819.
EcoGene	EG14066. yegW.
Phylogenomic databases
eggNOG	COG2188.
HOGENOM	HOG000228717.
OMA	SIEESWA.
ProtClustDB	CLSK880289.
Enzyme and pathway databases
BioCyc	EcoCyc:G7133-MONOMER. ECOL316407:JW2088-MONOMER.
Gene expression databases
Genevestigator	P0ACM5.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR000524. Tscrpt_reg_HTH_GntR. IPR011663. UTRA. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00392. GntR. 1 hit. PF07702. UTRA. 1 hit. [Graphical view]
PRINTS	PR00035. HTHGNTR.
SMART	SM00345. HTH_GNTR. 1 hit. SM00866. UTRA. 1 hit. [Graphical view]
PROSITE	PS50949. HTH_GNTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YEGW_ECOLI

Accession

Primary (citable) accession number: P0ACM5
Secondary accession number(s): O08014, P76420

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program